Blood and Marrow Transplant Clinical Trials Network State of the Science Symposium 2007

Received 17 August 2007; accepted 20 August 2007.

Abstract

Outcomes of hematopoietic cell transplantation are steadily improving. New techniques have reduced transplant toxicities, and there are new sources of hematopoietic stem cells from unrelated donors. In June 2007 the Blood and Marrow Transplant Clinical Trials Network convened a State of the Science Symposium of more than 200 participants in Ann Arbor to identify the most compelling clinical research opportunities in the field. This report summarizes the symposium’s discussions and identifies eleven high priority clinical trials that the network plans to pursue over the course of the next several years.

Key Words: Hematopoietic cell transplantation, Clinical Trials Network, Clinical trials, Graft versus host disease, Acute myeloid leukemia, Acute lymphocytic leukemia, Chronic lymphocytic leukemia, T cell lymphoma, Hemaphogocytic lymphohistiocytosis, Crohn’s disease, Cell therapy, Biomarkers, Quality of life

1 University of Michigan, Ann Arbor, Michigan

2 H. Lee Moffitt Cancer Center, Tampa, Florida

3 University of Pennsylvania, Philadelphia, Pennsylvania

4 Dana-Farber Cancer Institute, Boston, Massachusetts

5 University of Florida Shands Cancer Center, Gainesville, Florida

6 Fred Hutchinson Cancer Research Center, Seattle, Washington

7 BC Children’s Hospital/UBC, Vancouver, Canada

8 Stanford University, Stanford, California

9 University of Texas M.D. Anderson Cancer Center, Houston, Texas

10 Medical College of Wisconsin, Milwaukee, Wisconsin

11 Baylor College of Medicine, Houston, Texas

12 CIBMTR, Milwaukee, Wisconsin

Correspondence and reprint requests: James L.M. Ferrara, M.D., 1500 E. Medical Center Dr., 6303 Cancer Center, Ann Arbor, MI.

PII: S1083-8791(07)00384-9

doi:10.1016/j.bbmt.2007.08.005

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