Biology of Blood and Marrow Transplantation
Volume 15, Issue 12 , Pages 1523-1530 , December 2009

Antibody Response to Polysaccharide Conjugate Vaccines after Nonmyeloablative Allogeneic Stem Cell Transplantation

  • Aafke Meerveld-Eggink

      Affiliations

    • Department of Internal Medicine, St. Antonius Hospital, Nieuwegein, The Netherlands
  • ,
  • Ankie M.T. van der Velden

      Affiliations

    • Department of Hematology, Vrije Universiteit (VU) University Medical Center, Amsterdam, The Netherlands
  • ,
  • Gert J. Ossenkoppele

      Affiliations

    • Department of Hematology, Vrije Universiteit (VU) University Medical Center, Amsterdam, The Netherlands
  • ,
  • Arjan A. van de Loosdrecht

      Affiliations

    • Department of Hematology, Vrije Universiteit (VU) University Medical Center, Amsterdam, The Netherlands
  • ,
  • Douwe H. Biesma

      Affiliations

    • Department of Internal Medicine and Hematology, University Medical Center, Utrecht, The Netherlands
  • ,
  • Ger T. Rijkers

      Affiliations

    • Department of Medical Microbiology and Immunology, St. Antonius Hospital, Nieuwegein, The Netherlands
    • Corresponding Author InformationCorrespondence and reprint requests: GT Rijkers, PhD, Department of Medical Microbiology and Immunology, St. Antonius Hospital Nieuwegein, Koekoekslaan 1, PO Box 2500, 3534 CM Nieuwegein, The Netherlands.

Received 7 May 2009 ,Accepted 22 July 2009.

References 

  1. Ljungman P, Engelhard D, de la Cámara R, et al. Vaccination of stem cell transplant recipients: recommendations of the infectious diseases working party of the EBMT. Bone Marrow Transplant. 2005;35:737–746
  2. Vance E, George S, Guinan EC, et al. Comparison of multiple immunization schedules for Haemophilus influenzae type b-conjugate and tetanus toxoid vaccines following bone marrow transplantation. Bone Marrow Transplant. 1998;22:735–741
  3. Ljungman P, Wiklund-Hammarsten M, Duraj V, et al. Response to tetanus toxoid immunization after allogeneic bone marrow transplantation. J Infect Dis. 1990;162:496–500
  4. Center for Disease Control and Prevention . Guidelines for preventing opportunistic infections among hematopoietic stem cell transplant recipients: recommendations of CDC, the Infectious Disease Society of America, and the American Society of Blood and Marrow Transplantation. MMWR Morb Mortal Wkly Rep. 2000;49:1–128
  5. Siber GR, Ambrosino DM, McIver J, et al. Preparation of human hyperimmune globulin to Haemophilus influenza b, Streptococcus pneumoniae, and Neisseria meningitidis. Infect Immun. 1984;45:248–254
  6. Goldblatt D, Levinsky RJ, Turner MW. Role of cell wall polysaccharide in the assessment of IgG antibodies to the capsular polysaccharides of Streptococcus pneumoniae in childhood. J Infect Dis. 1992;166:632–634
  7. Hermann DJ, Hamilton RG, Barington T, et al. Quantitation of human IgG subclass antibodies to Haemophilus influenzae type b capsular polysaccharide: results of an international collaborative study using enzyme immunoassay methodology. J Immunol Methods. 1992;148:101–114
  8. Käyhty H, Peltola H, Karanko V, Mäkelä PH. The protective level of serum antibodies to the capsular polysaccharide of Haemophilus Influenzae type b. J Infect Dis. 1983;147:1100
  9. Käythy H. Difficulties in establishing a serological correlate of protection after immunization with Haemophilus influenzae conjugate vaccines. Biologicals. 1994;22:397–402
  10. Plotkin SA. Immunologic correlates of protection induced by vaccination. Pediatr Infect Dis J. 2001;20:63–75
  11. Gottlieb S, McLaughlin FX, Levine L, et al. Long-term immunity to tetanus—a statistical evaluation and its clinical implications. Am J Public Health Nations Health. 1964;54:961–971
  12. Center for Disease Control and Prevention . Preventing tetanus, diphtheria, and pertussis among adolescents: use of tetanus toxoid, reduced diphtheria toxoid and acellular pertussis vaccines. Recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Morb Mortal Wkly Rep. 2006;55
  13. Wernette CM, Frasch CE, Madore D, et al. Enzyme-linked immunosorbent assay for quantitation of human antibodies to pneumococcal polysaccharides. Clin Diagn Lab Immunol. 2003;10:514–519
  14. Skovsted IC, Kerrn MB, Sonne-Hansen J, et al. Purification and structure characterization of the active component in the pneumococcal 22F polysaccharide capsule used for adsorption in pneumococcal enzyme-linked immunosorbent assays. Vaccine. 2007;25:6490–6500
  15. World Health Organization . Pneumococcal conjugate vaccines. Recommendations for the production and control of pneumococcal conjugate vaccines. WHO Tech Rep Ser. 2005;927(annex 2):64–98
  16. Savage WJ, Bleesing JJH, Douek D, et al. Lymphocyte reconstitution following non-myeloablative hematopoietic stem cell transplantation follows 2 patterns depending on age and donor/recipient chimerism. Bone Marrow Transplant. 2001;28:463–471
  17. Morecki S, Gelfand Y, Nagler A, et al. Immune reconstitution following allogeneic stem cell transplantation in recipients conditioned by low intensity vs myeloablative regimen. Bone Marrow Transplant. 2001;28:243–249
  18. Maris M, Boeckh M, Storer B, et al. Immunologic recovery after hematopoietic cell transplantation with nonmyeloablative conditioning. Exp Hematol. 2003;31:941–952
  19. van der Velden AMT, Claessen AM, van Velzen-Blad H, et al. Vaccination responses and lymphocyte subsets after autologous stem cell transplantation. Vaccine. 2007;25:8512–8517
  20. Molrine DC, Guinan EC, Antin JH, et al. Donor immunization with Haemophilus influenzae type B (HIB)-conjugate vaccine in allogeneic bone marrow transplantation. Blood. 1996;87:3012–3018
  21. Parkkali T, Ölander R-M, Ruutu T, et al. A randomized comparison between early and late vaccination with tetanus toxoid vaccine after allogeneic BMT. Bone Marrow Transplant. 1997;19:933–938
  22. Molrine DC, Antin JH, Guinan EC, et al. Donor immunizaton with pneumococcal conjugate vaccine and early protective antibody responses following allogeneic hematopoietic cell transplantation. Blood. 2003;101:831–836
  23. Storek J, Viganego F, Dawson MA, et al. Factors affecting antibody levels after allogeneic hematopoietic cell transplantation. Blood. 2003;101:3319–3324
  24. Cordonnier C, Labopin M, Chesnel Virginie, et al. Immune response to the 23-valent polysaccharide pneumococcal vaccine (PPV23) after the 7-valent conjugate vaccine (PCV7) in allogeneic stem cell transplant (SCT) recipients: results of the EBMT IDWP01 Trial. Blood ASH Annu Meet Abstr. 2008;112:Abstract 350

 Financial disclosure: See Acknowledgments on page 1529.

PII: S1083-8791(09)00361-9

doi: 10.1016/j.bbmt.2009.07.020

Biology of Blood and Marrow Transplantation
Volume 15, Issue 12 , Pages 1523-1530 , December 2009