Biology of Blood and Marrow Transplantation
Volume 10, Issue 3 , Pages 171-177 , March 2004

Donor chimerism does not predict response to donor lymphocyte infusion for relapsed chronic myelogenous leukemia after allogeneic hematopoietic cell transplantation

  • Elena G Chiorean

      Affiliations

    • Blood and Marrow Transplant Program, University of Minnesota, Minneapolis, Minnesota, USA
    • Division of Medical Hematology, University of Minnesota, Minneapolis, Minnesota, USA
    • ,
  • Todd E DeFor

      Affiliations

    • Blood and Marrow Transplant Program, University of Minnesota, Minneapolis, Minnesota, USA
    • ,
  • Daniel J Weisdorf

      Affiliations

    • Blood and Marrow Transplant Program, University of Minnesota, Minneapolis, Minnesota, USA
    • Division of Medical Hematology, University of Minnesota, Minneapolis, Minnesota, USA
    • ,
  • Bruce R Blazar

      Affiliations

    • Blood and Marrow Transplant Program, University of Minnesota, Minneapolis, Minnesota, USA
    • Division of Pediatric Hematology, Oncology and Transplantation, University of Minnesota, Minneapolis, Minnesota, USA
    • ,
  • Philip B McGlave

      Affiliations

    • Blood and Marrow Transplant Program, University of Minnesota, Minneapolis, Minnesota, USA
    • Division of Medical Hematology, University of Minnesota, Minneapolis, Minnesota, USA
    • ,
  • Linda J Burns

      Affiliations

    • Blood and Marrow Transplant Program, University of Minnesota, Minneapolis, Minnesota, USA
    • Division of Medical Hematology, University of Minnesota, Minneapolis, Minnesota, USA
    • ,
  • Charlotte Brown

      Affiliations

    • Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota, USA
    • ,
  • Jeffrey S Miller

      Affiliations

    • Blood and Marrow Transplant Program, University of Minnesota, Minneapolis, Minnesota, USA
    • Division of Medical Hematology, University of Minnesota, Minneapolis, Minnesota, USA
    • Corresponding Author InformationCorrespondence and reprint requests: Jeffrey S. Miller, MD, Department of Medicine, University of Minnesota Cancer Center, MMC 806, Division of Hematology, Oncology and Transplantation, Harvard St. at E. River Rd., Minneapolis, MN 55455 USA

Received 25 April 2003 ,Accepted 14 October 2003.

  • Image Result

    Survival after DLI for CML and non-CML patients.

    Survival after DLI for CML and non-CML patients.

  • Image Result

    Overall survival after DLI for CML patients based on the pre-DLI donor chimerism.

    Overall survival after DLI for CML patients based on the pre-DLI donor chimerism.

  • Image Result

    Complete response rates based on the pre-DLI donor chimerism levels (CML patients: n = 4 for 0%, n = 9 for 1%–9%, n = 5 for 10%–50%, and n = 6 for 51%–100% pre-DLI donor chimerism; non-CML patients: n

    Complete response rates based on the pre-DLI donor chimerism levels (CML patients: n = 4 for 0%, n = 9 for 1%–9%, n = 5 for 10%–50%, and n = 6 for 51%–100% pre-DLI donor chimerism; non-CML patients: n = 1 for 0%, n = 2 for 1%–9%, n = 2 for 10%–50%, and n = 13 for 51%–100% pre-DLI donor chimerism).

PII: S1083-8791(03)00395-1

doi: 10.1016/j.bbmt.2003.10.004

Biology of Blood and Marrow Transplantation
Volume 10, Issue 3 , Pages 171-177 , March 2004

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