Temporal discordance between graft-versus-leukemia and graft-versus-host responses: A strategy for the separation of graft-versus-leukemia/graft-versus-host reactivity?

Temporal kinetics of GVL and GVH responses. A, Number of patients in whom GVL and GVH reactivity occurred concurrently (white bar), in whom a GVL response antedated GVHD (black bar), or in whom a GVL effect was documented after the onset of GVHD (gray bar). B, Percentage of patients who had either a GVL (closed squares) or a GVH (open squares) response after the administration of DLI. C, Scatterplot of total T-cell dose versus the interval between the relative onset of GVL and GVH reactivity in 18 patients who had both GVL and GVH responses. Data points represent individual patients.