Biology of Blood and Marrow Transplantation
Volume 11, Issue 8 , Pages 593-599 , August 2005

Efficacy of Reduced-Intensity Allogeneic Stem Cell Transplantation in Chemotherapy-Refractory Non-Hodgkin Lymphoma

  • Robert M. Dean

      Affiliations

    • Experimental Transplantation and Immunology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland
    • ,
  • Daniel H. Fowler

      Affiliations

    • Experimental Transplantation and Immunology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland
    • ,
  • Wyndham H. Wilson

      Affiliations

    • Experimental Transplantation and Immunology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland
    • ,
  • Jeanne Odom

      Affiliations

    • Experimental Transplantation and Immunology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland
    • ,
  • Seth M. Steinberg

      Affiliations

    • Biostatistics and Data Management Section, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland
    • ,
  • Catherine Chow

      Affiliations

    • Diagnostic Radiology Department, Warren G. Magnuson Clinical Center, National Institutes of Health, Bethesda, Maryland
    • ,
  • Claude Kasten-Sportes

      Affiliations

    • Experimental Transplantation and Immunology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland
    • ,
  • Ronald E. Gress

      Affiliations

    • Experimental Transplantation and Immunology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland
    • ,
  • Michael R. Bishop

      Affiliations

    • Experimental Transplantation and Immunology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland
    • Corresponding Author InformationCorrespondence and reprint requests: Michael R. Bishop, MD, Experimental Transplantation and Immunology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 10 Center Drive, CRC 3-3330, MSC 1203, Bethesda, MD 20892-1203

Received 26 January 2005 ,Accepted 25 April 2005.

References 

  1. Philip T , Guglielmi C , Hagenbeek A , et al.   Autologous bone marrow transplantation as compared with salvage chemotherapy in relapses of chemotherapy-sensitive non-Hodgkin’s lymphoma . N Engl J Med . 1995;333:1540–1545
  2. Haioun C , Lepage E , Gisselbrecht C , et al.   Benefit of autologous bone marrow transplantation over sequential chemotherapy in poor-risk aggressive non-Hodgkin’s lymphoma (updated results of the prospective study LNH87-2. Groupe d’Etude des Lymphomes de l’Adulte) . J Clin Oncol . 1997;15:1131–1137
  3. Freedman AS , Neuberg D , Mauch P , et al.   Long-term follow-up of autologous bone marrow transplantation in patients with relapsed follicular lymphoma . Blood . 1999;94:3325–3333
  4. Rohatiner A , Johnson P , Price C , et al.   Myeloablative therapy with autologous bone marrow transplantation as consolidation therapy for recurrent follicular lymphoma . J Clin Oncol . 1994;12:1177–1184
  5. Hamlin PA , Zelenetz AD , Kewalramani T , et al.   Age-adjusted International Prognostic Index predicts autologous stem cell transplantation outcome for patients with relapsed or primary refractory diffuse large B-cell lymphoma . Blood . 2003;102:1989–1996
  6. Jones RJ , Ambinder RF , Piantadosi S , Santos GW . Evidence of a graft-versus-lymphoma effect associated with allogeneic bone marrow transplantation . Blood . 1991;77:649–653
  7. Mandigers CM , Meijerink JP , Raemaekers JM , Schattenberg AV , Mensink EJ . Graft-versus-lymphoma effect of donor leucocyte infusion shown by real-time quantitative PCR analysis of t(14;18) . Lancet . 1998;352:1522–1523
  8. Ratanatharathorn V , Uberti J , Karanes C , et al.   Prospective comparative trial of autologous versus allogeneic bone marrow transplantation in patients with non-Hodgkin’s lymphoma . Blood . 1994;84:1050–1055
  9. Peniket AJ , Ruiz De Elvira MC , Taghipour G , et al.   An EBMT registry matched study of allogeneic stem cell transplants for lymphoma (allogeneic transplantation is associated with a lower relapse rate but a higher procedure-related mortality rate than autologous transplantation) . Bone Marrow Transplant . 2003;31:667–678
  10. Giralt S , Estey E , Albitar M , et al.   Engraftment of allogeneic hematopoietic progenitor cells with purine analog-containing chemotherapy (harnessing graft-versus-leukemia without myeloablative therapy) . Blood . 1997;89:4531–4536
  11. Slavin S , Nagler A , Naparstek E , et al.   Nonmyeloablative stem cell transplantation and cell therapy as an alternative to conventional bone marrow transplantation with lethal cytoreduction for the treatment of malignant and nonmalignant hematologic diseases . Blood . 1998;91:756–763
  12. Robinson SP , Goldstone AH , Mackinnon S , et al.   Chemoresistant or aggressive lymphoma predicts for a poor outcome following reduced-intensity allogeneic progenitor cell transplantation (an analysis from the Lymphoma Working Party of the European Group for Blood and Bone Marrow Transplantation) . Blood . 2002;100:4310–4316
  13. Wilson WH , Bryant G , Bates S , et al.   EPOCH chemotherapy (toxicity and efficacy in relapsed and refractory non-Hodgkin’s lymphoma) . J Clin Oncol . 1993;11:1573–1582
  14. Petrus MJ , Williams JF , Eckhaus MA , Gress RE , Fowler DH . An immunoablative regimen of fludarabine and cyclophosphamide prevents fully MHC-mismatched murine marrow graft rejection independent of GVHD . Biol Blood Marrow Transplant . 2000;6:182–189
  15. Dean RM , Bishop MR , Fowler D , Odom J , Gress R , Wilson WH . EPOCH-fludarabine, a novel combination chemotherapy regimen for disease control and immune depletion before reduced-intensity allogeneic stem cell transplantation . [abstract] Proc Am Soc Clin Oncol . 2003;22:839
  16. Harris NL , Jaffe ES , Stein H , et al.   A revised European-American classification of lymphoid neoplasms (a proposal from the International Lymphoma Study Group) . Blood . 1994;84:1361–1392
  17. In:  Jaffe ES ,  Harris NL ,  Stein H ,  Vardiman JW editor. World Health Organization Classification of Tumours (Pathology and Genetics of Tumours of Haematopoietic and Lymphoid Tissues) . Lyon, France: IARC Press; 2001;
  18. Fowler D , Hou J , Foley J , et al.   Phase I clinical trial of donor T-helper type-2 cells after immunoablative, reduced intensity allogeneic PBSC transplant . Cytotherapy . 2002;4:429–430
  19. Bishop MR , Hou JW , Wilson WH , et al.   Establishment of early donor engraftment after reduced-intensity allogeneic hematopoietic stem cell transplantation to potentiate the graft-versus-lymphoma effect against refractory lymphomas . Biol Blood Marrow Transplant . 2003;9:162–169
  20. Cheson BD , Horning SJ , Coiffier B , et al.   Report of an international workshop to standardize response criteria for non-Hodgkin’s lymphomas. NCI Sponsored International Working Group . J Clin Oncol . 1999;17:1244
  21. Kaplan EL , Meier P . Nonparametric estimation from incomplete observations . J Am Stat Assoc . 1958;53:457–481
  22. Mantel N . Evaluation of survival data and two new rank order statistics arising in its consideration . Cancer Chemother Rep . 1966;50:163–170
  23. Cox D . Regression models and life tables . J R Stat Soc B . 1972;34:187–202
  24. Matthews DE , Farewell VT . In: Using and Understanding Medical Statistics . Basel, Switzerland: Karger; 1996;p. 150–160
  25. Agresti A . Categorical Data Analysis . New York: Wiley; 1990; 79–129
  26. Bishop MR , Steinberg SM , Gress RE , et al.   Targeted pretransplant host lymphocyte depletion prior to T-cell depleted reduced-intensity allogeneic stem cell transplantation . Br J Haematol . 2004;126:837–843
  27. Maloney DG . Graft-vs-lymphoma effect in various histologies of non-Hodgkin’s lymphoma . Leuk Lymphoma . 2003;44(suppl 3):S99–S105
  28. Deeg HJ , Lin D , Leisenring W , et al.   Cyclosporine or cyclosporine plus methylprednisolone for prophylaxis of graft-versus-host disease (a prospective, randomized trial) . Blood . 1997;89:3880–3887
  29. Ito M , Shizuru JA . Graft-vs-lymphoma effect in an allogeneic hematopoietic stem cell transplantation model . Biol Blood Marrow Transplant . 1999;5:357–368
  30. Mizoguchi H , O’Shea JJ , Longo DL , Loeffler CM , McVicar DW , Ochoa AC . Alterations in signal transduction molecules in T lymphocytes from tumor-bearing mice . Science . 1992;258:1795–1798

PII: S1083-8791(05)00261-2

doi: 10.1016/j.bbmt.2005.04.005

Biology of Blood and Marrow Transplantation
Volume 11, Issue 8 , Pages 593-599 , August 2005

Article Tools

* Image Usage & Resolution