Biology of Blood and Marrow Transplantation
Volume 11, Issue 7 , Pages 551-557 , July 2005

Sirolimus and Thrombotic Microangiopathy after Allogeneic Hematopoietic Stem Cell Transplantation

  • Corey Cutler

      Affiliations

    • Department of Medical Oncology, Dana-Farber Cancer Institute and Brigham and Women’s Hospital, Boston, Massachusetts
    • Corresponding Author InformationCorrespondence and reprint requests: Corey Cutler, MD, MPH, FRCP(C), Department of Medical Oncology, Dana-Farber Cancer Institute, 44 Binney St., Boston, MA 02115
  • ,
  • N. Lynn Henry

      Affiliations

    • Department of Medical Oncology, Dana-Farber Cancer Institute and Brigham and Women’s Hospital, Boston, Massachusetts
  • ,
  • Colm Magee

      Affiliations

    • Department of Nephrology, Brigham and Women’s Hospital, Boston, Massachusetts
  • ,
  • Shuli Li

      Affiliations

    • Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute and Brigham and Women’s Hospital, Boston, Massachusetts
  • ,
  • Haesook T. Kim

      Affiliations

    • Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute and Brigham and Women’s Hospital, Boston, Massachusetts
  • ,
  • Edwin Alyea

      Affiliations

    • Department of Medical Oncology, Dana-Farber Cancer Institute and Brigham and Women’s Hospital, Boston, Massachusetts
  • ,
  • Vincent Ho

      Affiliations

    • Department of Medical Oncology, Dana-Farber Cancer Institute and Brigham and Women’s Hospital, Boston, Massachusetts
  • ,
  • Stephanie J. Lee

      Affiliations

    • Department of Medical Oncology, Dana-Farber Cancer Institute and Brigham and Women’s Hospital, Boston, Massachusetts
  • ,
  • Robert Soiffer

      Affiliations

    • Department of Medical Oncology, Dana-Farber Cancer Institute and Brigham and Women’s Hospital, Boston, Massachusetts
  • ,
  • Joseph H. Antin

      Affiliations

    • Department of Medical Oncology, Dana-Farber Cancer Institute and Brigham and Women’s Hospital, Boston, Massachusetts

Received 21 February 2005 ,Accepted 21 April 2005.

References 

  1. Storb R , Deeg HJ , Pepe M , et al.   Methotrexate and cyclosporine versus cyclosporine alone for prophylaxis of graft-versus-host disease in patients given HLA-identical marrow grafts for leukemia (long-term follow-up of a controlled trial) . Blood . 1989;73:1729–1734
  2. Cutler C , Li S , Kim HT , et al.   Mucositis after allogeneic hematopoietic stem cell transplantation (a cohort study of methotrexate- and non-methotrexate-containing graft-versus-host disease prophylaxis regimens) . Biol Blood Marrow Transplant. . 2005;11:383–388
  3. Ho VT , Weller E , Lee SJ , et al.   Prognostic factors for early severe pulmonary complications after hematopoietic stem cell transplantation . Biol Blood Marrow Transplant. . 2001;7:223–229
  4. Chao NJ , Snyder DS , Jain M , et al.   Equivalence of 2 effective graft-versus-host disease prophylaxis regimens (results of a prospective double-blind randomized trial) . Biol Blood Marrow Transplant. . 2000;6:254–261
  5. Cutler C , Antin JH . Omission of day +11 methotrexate after matched-related allogeneic peripheral blood stem cell transplantation does not increase the risk of graft-vs.-host disease . [abstract] Biol Blood Marrow Transplant. . 2002;8:85
  6. Daly AS , Xenocostas A , Lipton JH . Transplantation-associated thrombotic microangiopathy (twenty-two years later) . Bone Marrow Transplant. . 2002;30:709–715
  7. McLeod BC . Thrombotic microangiopathies in bone marrow and organ transplant patients . J Clin Apheresis. . 2002;17:118–123
  8. Pettitt AR , Clark RE . Thrombotic microangiopathy following bone marrow transplantation . Bone Marrow Transplant. . 1994;14:495–504
  9. Fuge R , Bird JM , Fraser A , et al.   The clinical features, risk factors and outcome of thrombotic thrombocytopenic purpura occurring after bone marrow transplantation . Br J Haematol. . 2001;113:58–64
  10. Iacopino P , Pucci G , Arcese W , et al.  Gruppo Italiano Trapianto Midollo Osseo (GITMO)   Severe thrombotic microangiopathy (an infrequent complication of bone marrow transplantation) . Bone Marrow Transplant. . 1999;24:47–51
  11. Paquette RL , Tran L , Landaw EM . Thrombotic microangiopathy following allogeneic bone marrow transplantation is associated with intensive graft-versus-host disease prophylaxis . Bone Marrow Transplant. . 1998;22:351–357
  12. Ruutu T , Hermans J , Niederwieser D , et al.   Thrombotic thrombocytopenic purpura after allogeneic stem cell transplantation (a survey of the European Group for Blood and Marrow Transplantation (EBMT)) . Br J Haematol. . 2002;118:1112–1119
  13. George JN , Li X , McMinn JR , et al.   Thrombotic thrombocytopenic purpura-hemolytic uremic syndrome following allogeneic HPC transplantation (a diagnostic dilemma) . Transfusion . 2004;44:294–304
  14. Pham PT , Pham PC , Danovitch GM , et al.   Sirolimus-associated pulmonary toxicity . Transplantation . 2004;77:1215–1220
  15. Trimarchi HM , Truong LD , Brennan S , Gonzalez JM , Suki WN . FK506-associated thrombotic microangiopathy (report of two cases and review of the literature) . Transplantation . 1999;67:539–544
  16. Basara N , Blau WI , Kiehl MG , et al.   Mycophenolate mofetil for the prophylaxis of acute GVHD in HLA-mismatched bone marrow transplant patients . Clin Transplant. . 2000;14:121–126
  17. Devine SM , Geller RB , Lin LB , et al.   The outcome of unrelated donor bone marrow transplantation in patients with hematologic malignancies using tacrolimus (FK506) and low dose methotrexate for graft-versus-host disease prophylaxis . Biol Blood Marrow Transplant. . 1997;3:25–33
  18. Przepiorka D , Khouri I , Ippoliti C , et al.   Tacrolimus and minidose methotrexate for prevention of acute graft-versus-host disease after HLA-mismatched marrow or blood stem cell transplantation . Bone Marrow Transplant. . 1999;24:763–768
  19. Uberti JP , Ayash L , Braun T , et al.   Tacrolimus as monotherapy or combined with minidose methotrexate for graft-versus-host disease prophylaxis after allogeneic peripheral blood stem cell transplantation (long-term outcomes) . Bone Marrow Transplant. . 2004;34:425–431
  20. Groth CG , Backman L , Morales JM , et al.  Sirolimus European Renal Transplant Study Group   Sirolimus (rapamycin)-based therapy in human renal transplantation (similar efficacy and different toxicity compared with cyclosporine) . Transplantation . 1999;67:1036–1042
  21. Johnson RW . Sirolimus (Rapamune) in renal transplantation . Curr Opin Nephrol Hypertens. . 2002;11:603–607
  22. Longoria J , Roberts RF , Marboe CC , et al.   Sirolimus (rapamycin) potentiates cyclosporine in prevention of acute lung rejection . J Thorac Cardiovasc Surg. . 1999;117:714–718
  23. Trotter JF . Sirolimus in liver transplantation . Transplant Proc. . 2003;35:S193–S200
  24. Antin JH , Kim HT , Cutler C , et al.   Sirolimus, tacrolimus, and low-dose methotrexate for graft-versus-host disease prophylaxis in mismatched related donor or unrelated donor transplantation . Blood . 2003;102:1601–1605
  25. Cutler C , Kim HT , Hochberg E , et al.   Sirolimus and tacrolimus without methotrexate as graft-versus-host disease prophylaxis after matched related donor peripheral blood stem cell transplantation . Biol Blood Marrow Transplant. . 2004;10:328–336
  26. Barone G , Gurley B , Abul-Ezz S , Gökden N . Sirolimus-induced thrombotic microangiopathy in a renal transplant recipient . Am J Kidney Dis. . 2003;42:202–206
  27. Langer RM , Van Buren CT , Katz SM , Kahan BD . De novo hemolytic uremic syndrome after kidney transplantation in patients treated with cyclosporine-sirolimus combination . Transplantation . 2002;73:756–760
  28. Paramesh AS , Grosskreutz C , Florman SS , et al.   Thrombotic microangiopathy associated with combined sirolimus and tacrolimus immunosuppression after intestinal transplantation . Transplantation . 2004;77:129–131
  29. Robson M , Cote I , Abbs I , Koffman G , Goldsmith D . Thrombotic micro-angiopathy with sirolimus-based immunosuppression (potentiation of calcineurin-inhibitor-induced endothelial damage?) . Am J Transplant. . 2003;3:324–327
  30. Saikali JA , Truong LD , Suki WN . Sirolimus may promote thrombotic microangiopathy . Am J Transplant. . 2003;3:229–230
  31. Benito AI , Furlong T , Martin PJ , et al.   Sirolimus (rapamycin) for the treatment of steroid-refractory acute graft-versus-host disease . Transplantation . 2001;72:1924–1929
  32. Digon BJ , Rother KI , Hirshberg B , Harlan DM . Sirolimus-induced interstitial pneumonitis in an islet transplant recipient . Diabetes Care . 2003;26:3191
  33. Vlahakis NE , Rickman OB , Morgenthaler T . Sirolimus-associated diffuse alveolar hemorrhage . Mayo Clin Proc. . 2004;79:541–545
  34. Couriel D , Hicks K , Saliba R , et al.   Sirolimus (rapamycin) for treatment of steroid-refractory chronic graft versus host disease . [abstract] Biol Blood Marrow Transplant. . 2003;9:67
  35. Johnston L , Shizuru J , Stockerl-Goldstein K , et al.   Rapamycin for treatment of chronic graft versus host disease . [abstract] Biol Blood Marrow Transplant. . 2002;8:87
  36. Babinska A , Markell MS , Salifu MO , et al.   Enhancement of human platelet aggregation and secretion induced by rapamycin . Nephrol Dial Transplant. . 1998;13:3153–3159
  37. Podder H , Stepkowski SM , Napoli K , Kahan BD . Pharmacokinetic interactions between sirolimus and cyclosporine exacerbate renal dysfunction . Transplant Proc. . 2001;33:1086
  38. Yatscoff RW , Fryer J , Thliveris JA . Comparison of the effect of rapamycin and FK506 on release of prostacyclin and endothelin in vitro . Clin Biochem. . 1993;26:409–414
  39. Elliott MA , Nichols WL , Plumhoff EA , et al.   Posttransplantation thrombotic thrombocytopenic purpura (a single-center experience and a contemporary review) . Mayo Clin Proc. . 2003;78:421–430
  40. van der Plas RM , Schiphorst ME , Huizinga EG , et al.   von Willebrand factor proteolysis is deficient in classic, but not in bone marrow transplantation-associated, thrombotic thrombocytopenic purpura . Blood . 1999;93:3798–3802
  41. Allford SL , Bird JM , Marks DI . Thrombotic thrombocytopenic purpura following stem cell transplantation . Leuk Lymphoma. . 2002;43:1921–1926
  42. Arai S , Allan C , Streiff M , et al.   Von Willebrand factor-cleaving protease activity and proteolysis of von Willebrand factor in bone marrow transplant-associated thrombotic microangiopathy . Hematol J. . 2001;2:292–299
  43. Vesely SK , George JN , Lammle B , et al.   ADAMTS13 activity in thrombotic thrombocytopenic purpura-hemolytic uremic syndrome (relation to presenting features and clinical outcomes in a prospective cohort of 142 patients) . Blood . 2003;102:60–68
  44. Daly AS , Hasegawa WS , Lipton JH , Messner HA , Kiss TL . Transplantation-associated thrombotic microangiopathy is associated with transplantation from unrelated donors, acute graft-versus-host disease and venoocclusive disease of the liver . Transfus Apheresis Sci. . 2002;27:3–12
  45. Roy V , Rizvi MA , Vesely SK , George JN . Thrombotic thrombocytopenic purpura-like syndromes following bone marrow transplantation (an analysis of associated conditions and clinical outcomes) . Bone Marrow Transplant. . 2001;27:641–646
  46. Holler E , Kolb HJ , Hiller E , et al.   Microangiopathy in patients on cyclosporine prophylaxis who developed acute graft-versus-host disease after HLA-identical bone marrow transplantation . Blood . 1989;73:2018–2024
  47. Vangelista A , Frasca GM , Raimondi C , Liviano-D’Arcangelo G , Bonomini V . Effects of defibrotide in acute renal failure due to thrombotic microangiopathy . Haemostasis . 1986;16(suppl 1):51–54
  48. Bonomini V , Frasca GM , Raimondi C , Liviano DG , Vangelista A . Effect of a new antithrombotic agent (defibrotide) in acute renal failure due to thrombotic microangiopathy . Nephron . 1985;40:195–200
  49. Kanamori H , Takaishi Y , Takabayashi M , et al.   Clinical significance of fragmented red cells after allogeneic bone marrow transplantation . Int J Hematol. . 2003;77:180–184
  50. Lesesve JF , Salignac S , Lecompte T , Bordigoni P . Automated measurement of schistocytes after bone marrow transplantation . Bone Marrow Transplant. . 2004;34:357–362
  51. Zomas A , Saso R , Powles R , et al.   Red cell fragmentation (schistocytosis) after bone marrow transplantation . Bone Marrow Transplant. . 1998;22:777–780

 C.C. and N.L.H. contributed equally to this article.

PII: S1083-8791(05)00263-6

doi: 10.1016/j.bbmt.2005.04.007

Biology of Blood and Marrow Transplantation
Volume 11, Issue 7 , Pages 551-557 , July 2005