Biology of Blood and Marrow Transplantation
Volume 11, Issue 11 , Pages 903-911 , November 2005

Paclitaxel-Based High-Dose Chemotherapy with Autologous Stem Cell Rescue for Relapsed Germ Cell Cancer

  • Kim A. Margolin

      Affiliations

    • Department of Medical Oncology, City of Hope National Medical Center, Duarte, California
    • Corresponding Author InformationCorrespondence and reprint requests: Kim Margolin, MD, Department of Medical Oncology, City of Hope National Cancer Research Center, 1500 E. Duarte Rd., Duarte, CA 91010
    • ,
  • James H. Doroshow

      Affiliations

    • Department of Medical Oncology, City of Hope National Medical Center, Duarte, California
    • ,
  • Paul Frankel

      Affiliations

    • Department of Biostatistics, City of Hope National Medical Center, Duarte, California
    • ,
  • Warren Chow

      Affiliations

    • Department of Medical Oncology, City of Hope National Medical Center, Duarte, California
    • ,
  • Lucille A. Leong

      Affiliations

    • Department of Medical Oncology, City of Hope National Medical Center, Duarte, California
    • ,
  • Dean Lim

      Affiliations

    • Department of Medical Oncology, City of Hope National Medical Center, Duarte, California
    • ,
  • Mark McNamara

      Affiliations

    • Department of Medical Oncology, City of Hope National Medical Center, Duarte, California
    • ,
  • Robert J. Morgan

      Affiliations

    • Department of Medical Oncology, City of Hope National Medical Center, Duarte, California
    • ,
  • Stephen Shibata

      Affiliations

    • Department of Medical Oncology, City of Hope National Medical Center, Duarte, California
    • ,
  • George Somlo

      Affiliations

    • Department of Medical Oncology, City of Hope National Medical Center, Duarte, California
    • ,
  • Przemyslaw Twardowski

      Affiliations

    • Department of Medical Oncology, City of Hope National Medical Center, Duarte, California
    • ,
  • Yun Yen

      Affiliations

    • Department of Medical Oncology, City of Hope National Medical Center, Duarte, California
    • ,
  • Neil Kogut

      Affiliations

    • Department of Medical Oncology, City of Hope National Medical Center, Duarte, California
    • ,
  • Jeffrey Schriber

      Affiliations

    • Department of Medical Oncology, City of Hope National Medical Center, Duarte, California
    • ,
  • Joseph Alvarnas

      Affiliations

    • Department of Medical Oncology, City of Hope National Medical Center, Duarte, California
    • ,
  • Susan Stalter

      Affiliations

    • Department of Medical Oncology, City of Hope National Medical Center, Duarte, California

Received 5 January 2005 ,Accepted 14 July 2005.

References 

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  2. Motzer RJ , Bosl GJ . High-dose chemotherapy for resistant germ cell tumors (recent advances and future directions) . [review] J Natl Cancer Inst . 1992;84:1703–1709
  3. Margolin KA . High-dose chemotherapy and stem cell support in the treatment of germ cell cancer . [review] J Urol . 2003;169:1229–1233
  4. International Germ Cell Cancer Collaborative Group . International germ cell consensus classification (a prognostic factor-based staging system for metastatic germ cell cancers) . J Clin Oncol . 1997;15:594–603
  5. Motzer RJ , Bajorin DF , Schwartz LH , et al.   Phase II trial of paclitaxel shows antitumor activity in patients with previously treated germ cell tumors . J Clin Oncol . 1994;12:2277–2283
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  7. Somlo G , Doroshow JH , Synold T , et al.   High-dose paclitaxel in combination with doxorubicin, cyclophosphamide and peripheral blood progenitor cell rescue in patients with high-risk primary and responding metastatic breast carcinoma (toxicity profile, relationship to paclitaxel pharmacokinetics and short-term outcome) . Br J Cancer . 2001;84:1591–1598
  8. Leong LA , Raschko J , Somlo G , et al.   Phase I tandem cycle high-dose chemotherapy with cisplatin, etoposide, and cyclophosphamide followed by ifosfamide, carboplatin, escalating doses of paclitaxel and stem cell rescue . [abstract 479] Proc Am Soc Clin Oncol . 2001;20:121a
  9. Margolin KA , Doroshow JH , Ahn C , et al.   Treatment of germ cell cancer with two cycles of high-dose ifosfamide, carboplatin, and etoposide with autologous stem-cell support . J Clin Oncol . 1996;14:2631–2637
  10. Iniguez C , Larrode P , Mayordomo JI , et al.   Reversible peripheral neuropathy induced by a single administration of high-dose paclitaxel . Neurology . 1998;51:868–870
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  12. Somlo G , Sniecinski I , Odom-Maryon B , et al.   Effect of CD34+ selection and various schedules of stem cell reinfusion and granulocyte colony-stimulating factor priming on hematopoietic recovery after high-dose chemotherapy for breast cancer . Blood . 1997;89:1521–1528
  13. Beyer J , Kramar A , Mandanas R , et al.   High-dose chemotherapy as salvage treatment in germ cell tumors (a multivariate analysis of prognostic variables) . J Clin Oncol . 1996;14:2638–2645
  14. Raghavan D . Testicular cancer (maintaining the high cure rate) . Oncology . 2003;17:218–230
  15. Toner GC , Geller NL , Tan C , et al.   Serum tumor marker half-life during chemotherapy allows early prediction of complete response and survival in nonseminomatous germ cell tumors . Cancer Res . 1990;50:5904–5910
  16. Mazumdar M , Bajorin DF , Bacik J , et al.   Predicting outcome to chemotherapy in patients with germ cell tumors (the value of the rate of decline of human chorionic gonadotrophin and alpha-fetoprotein during therapy) . J Clin Oncol . 2001;19:2534–2541
  17. Motzer RJ , Mazumdar M , Gulati SC , et al.   Phase II trial of high-dose carboplatin and etoposide with autologous bone marrow transplantation in first-line therapy for patients with poor-risk germ cell tumors . J Natl Cancer Inst . 1993;85:1828–1835
  18. Motzer RJ , Mazumdar M , Bajorin DF , et al.   High-dose carboplatin, etoposide, and cyclophosphamide with autologous bone marrow transplantation in first-line therapy for patients with poor-risk germ cell tumors . J Clin Oncol . 1997;15:2546–2552
  19. Motzer RJ , Mazumdar M , Sheinfeld J , et al.   Sequential dose-intensive paclitaxel, ifosfamide, carboplatin, and etoposide salvage therapy for germ cell tumor patients . J Clin Oncol . 2000;18:1173–1180
  20. Kondagunta GV , Bacik J , Bajorin DF , et al.   Sequential dose-intensive paclitaxel plus ifosfamide and carboplatin plus etoposide with autologous stem cell transplantation for germ cell tumor (GCT) patients (pts) . [abstract] Proc Am Soc Clin Oncol . 2005;23:378
  21. Pico JL , Rosti G , Kramar A , et al.   A randomized trial of high-dose chemotherapy in the salvage treatment of patients failing first-line platinum chemotherapy for advanced germ cell tumors . Ann Oncol . 2005;16:1152–1159

PII: S1083-8791(05)00459-3

doi: 10.1016/j.bbmt.2005.07.010

Biology of Blood and Marrow Transplantation
Volume 11, Issue 11 , Pages 903-911 , November 2005

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