Biology of Blood and Marrow Transplantation
Volume 11, Issue 11 , Pages 823-861, November 2005

The Role of Cytotoxic Therapy with Hematopoietic Stem Cell Transplantation in the Therapy of Acute Lymphoblastic Leukemia in Children: An Evidence-Based Review

  • Theresa Hahn

      Affiliations

    • Roswell Park Cancer Institute, Buffalo, New York
    • Corresponding Author InformationCorrespondence and reprint requests: Theresa Hahn, PhD, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263
    • ,
  • Donna Wall

      Affiliations

    • Texas Transplant Institute, San Antonio, Texas
    • ,
  • Bruce Camitta

      Affiliations

    • Midwest Children’s Center, Medical College of Wisconsin and Children’s Hospital of Wisconsin, Milwaukee, Wisconsin
    • ,
  • Stella Davies

      Affiliations

    • Cincinnati Children’s Hospital and Medical Center, Cincinnati, Ohio
    • ,
  • Hildy Dillon

      Affiliations

    • The Leukemia and Lymphoma Society, White Plains, New York
    • ,
  • Paul Gaynon

      Affiliations

    • Children’s Hospital of Los Angeles, Los Angeles, California
    • ,
  • Richard A. Larson

      Affiliations

    • University of Chicago, Chicago, Illinois
    • ,
  • Susan Parsons

      Affiliations

    • Dana-Farber Cancer Institute/Harvard Medical School and Tufts New England Medical Center/Tufts University, Boston, Massachusetts
    • ,
  • Jerome Seidenfeld

      Affiliations

    • Blue Cross and Blue Shield Association Technology Evaluation Center, Chicago, Illinois
    • ,
  • Daniel Weisdorf

      Affiliations

    • University of Minnesota, Minneapolis, Minnesota
    • ,
  • Philip L. McCarthy Jr

      Affiliations

    • Roswell Park Cancer Institute, Buffalo, New York

Received 10 August 2005; accepted 10 August 2005.

Abstract 

Evidence supporting the role of hematopoietic stem cell transplantation (SCT) in the therapy of acute lymphoblastic leukemia (ALL) in children is presented and critically evaluated in this systematic evidence-based review. Specific criteria were used for searching the published literature and for grading the quality and strength of the evidence and the strength of the treatment recommendations. Treatment recommendations based on the evidence are presented in a table in this review (Summary of Treatment Recommendations Made by the Expert Panel for Pediatric Acute Lymphoblastic Leukemia) and were reached unanimously by a panel of ALL experts. The priority areas of needed future research in pediatric ALL are unrelated marrow or blood donor versus unrelated cord blood donor allogeneic SCT; alternative, nonfamily allogeneic donor versus autologous SCT; better methods for identifying high-relapse-risk patients; assessments of the effect of current chemotherapy regimens on early relapse; and use of pre-SCT detection of minimal residual disease to predict post-SCT outcomes.

Key words:  Acute lymphoblastic leukemia , Hematopoietic stem cell transplantation , Therapy , Pediatric

 

 All terms abbreviated in this article are defined in a Glossary of Terms, Appendix A, at the end of the article.

PII: S1083-8791(05)00567-7

doi:10.1016/j.bbmt.2005.08.035

Biology of Blood and Marrow Transplantation
Volume 11, Issue 11 , Pages 823-861, November 2005

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