The Importance of Age, Fludarabine, and Total Body Irradiation in the Incidence and Severity of Chronic Renal Failure after Allogeneic Hematopoietic Cell Transplantation

Cumulative incidence plots of chronic renal failure (CRF) and non–renal failure–associated mortality (NRFM) according to (A) age at transplantation and (B) fludarabine administration. CRF was defined as an estimated GFR of <60 mL/min/1.73 m² that persisted for at least 6 months [25].

Cumulative incidence plots of severe chronic renal failure (SCRF), end-stage renal failure (ESRF), and non–renal failure–associated mortality (NRFM) according to (A) total body irradiation fractionation and (B) fludarabine administration. Severe CRF and ESRF were defined as an estimated GFR of <30 mL/min/1.73 m² that persisted for at least 6 months [25].