Biology of Blood and Marrow Transplantation
Volume 12, Issue 1 , Pages 75-83 , January 2006

The Importance of Age, Fludarabine, and Total Body Irradiation in the Incidence and Severity of Chronic Renal Failure after Allogeneic Hematopoietic Cell Transplantation

  • Julio Delgado

      Affiliations

    • Department of Hematology, Royal Free & University College Medical School, London, United Kingdom
    • Corresponding Author InformationCorrespondence and reprint requests: Julio Delgado, MD, Department of Haematology, Birmingham Heartlands Hospital, Birmingham B9 5SS, United Kingdom.
  • ,
  • Nichola Cooper

      Affiliations

    • Department of Hematology, Royal Free & University College Medical School, London, United Kingdom
  • ,
  • Kirsty Thomson

      Affiliations

    • Department of Hematology, Royal Free & University College Medical School, London, United Kingdom
  • ,
  • Rafael Duarte

      Affiliations

    • Department of Hematology, Royal Free & University College Medical School, London, United Kingdom
  • ,
  • Michael Jarmulowicz

      Affiliations

    • Department of Histopathology, Royal Free & University College Medical School, London, United Kingdom
  • ,
  • Anna Cassoni

      Affiliations

    • Department of Clinical Oncology, Royal Free & University College Medical School, London, United Kingdom
  • ,
  • Panagiotis Kottaridis

      Affiliations

    • Department of Hematology, Royal Free & University College Medical School, London, United Kingdom
  • ,
  • Karl Peggs

      Affiliations

    • Department of Hematology, Royal Free & University College Medical School, London, United Kingdom
  • ,
  • Stephen Mackinnon

      Affiliations

    • Department of Hematology, Royal Free & University College Medical School, London, United Kingdom

Received 9 June 2005 ,Accepted 17 August 2005.

References 

  1. Thomas ED . Stem cell transplantation (past, present and future) . Stem Cells . 1994;12:539–544
  2. Curtis RE , Rowlings PA , Deeg HJ , et al.   Solid cancers after bone marrow transplantation . N Engl J Med . 1997;336:897–904
  3. Deeg HJ , Socie G . Malignancies after hematopoietic stem cell transplantation (many questions, some answers) . Blood . 1998;91:1833–1844
  4. Duell T , Vanlint MT , Ljungman P , et al.   Health and functional status of long-term survivors of bone marrow transplantation . Ann Intern Med . 1997;126:184–192
  5. Socie G , Salooja N , Cohen A , et al.   Nonmalignant late effects after allogeneic stem cell transplantation . Blood . 2003;101:3373–3385
  6. Thomas ED , Clift RA , Hersman J , et al.   Marrow transplantation for acute nonlymphoblastic leukemia in first remission using fractionated or single-dose irradiation . Int J Radiat Oncol Biol Phys . 1982;8:817–821
  7. Tichelli A , Gratwohl A , Egger T , et al.   Cataract formation after bone marrow transplantation . Ann Intern Med . 1993;119:1175–1180
  8. Borgstrom B , Bolme P . Thyroid function in children after allogeneic bone marrow transplantation . Bone Marrow Transplant . 1994;13:59–64
  9. Fink JC , Leisenring WM , Sullivan KM , Sherrard DJ , Weiss NS . Avascular necrosis following bone marrow transplantation . Bone . 1998;22:67–71
  10. Socie G , Devergie A , Girinsky T , et al.   Influence of the fractionation of total body irradiation on complications and relapse rate for chronic myelogenous leukemia . Int J Radiat Oncol Biol Phys . 1991;20:397–404
  11. Devergie A , Blaise D , Attal JD , et al.   Allogeneic bone marrow transplantation for chronic myeloid leukemia in first chronic phase: a randomized trial of busulfan-cytoxan versus cytoxan-total body irradiation as preparative regimen: a report from the French Society of Bone Marrow Graft . Blood . 1995;85:2263–2268
  12. Deeg HJ , Sullivan KM , Buckner CD , et al.   Marrow transplantation for acute non-lymphoblastic leukemia in first remission (toxicity and long-term follow-up of patients conditioned with single dose or fractionated total body irradiation) . Bone Marrow Transplant . 1986;1:151–157
  13. Goldman JM , Gale RP , Horowitz MM , et al.   Bone marrow transplantation for chronic myelogenous leukemia in chronic phase . Ann Intern Med . 1988;108:806–814
  14. Lawton CA , Cohen EP , Barber-Derus SW , et al.   Late renal dysfunction in adult survivors of bone marrow transplantation . Cancer . 1991;67:2795–2800
  15. Leblond V , Sutton L , Jacquiaud C , et al.   Evaluation of renal function in 60 long-term survivors of bone marrow transplantation . J Am Soc Nephrol . 1995;6:1661–1665
  16. Borg M , Hughes T , Horvath N , Rice M , Thomas A . Renal toxicity after total body irradiation . Int J Radiat Oncol Biol Phys . 2002;54:1165–1173
  17. Cohen EP . Renal failure after bone marrow transplantation . [letter] Lancet . 2001;357:6–7
  18. Moulder JE , Fish BL , Abrams RA . Renal toxicity following total body irradiation and syngeneic bone marrow transplantation . Transplantation . 1987;43:589–592
  19. Miralbell R , Bieri S , Mermillod B , et al.   Renal toxicity after allogeneic bone marrow transplantation (the combined effects of total-body irradiation and graft-versus-host disease) . J Clin Oncol . 1996;14:579–585
  20. Lawton CA , Cohen EP , Murray KJ , et al.   Long-term results of selective renal shielding in patients undergoing total body irradiation in preparation for bone marrow transplantation . Bone Marrow Transplant . 1997;20:1069–1074
  21. Cohen EP . Radiation nephropathy after bone marrow transplantation . Kidney Int . 2000;58:903–918
  22. Socie G , Tichelli A . Renal and other rare late complications following allogeneic stem cell transplantation . [letter] Blood . 2003;102:2695–2696
  23. Williams MV , Denekamp J . Radiation induced renal damage in mice (influence of fraction size) . Int J Radiat Oncol Biol Phys . 1984;10:885–893
  24. Manjunath G , Sarnak MJ , Levey AS . Prediction equations to estimate glomerular filtration rate (an update) . Curr Opin Nephrol Hypertens . 2001;10:785–792
  25. National Kidney Foundation (NKF) Kidney Disease Outcome Quality Initiative (K/DOQI) Advisory Board . K/DOQI clinical practice guidelines for chronic kidney disease (evaluation, classification, and stratification—Kidney Disease Outcome Quality Initiative) . Am J Kidney Dis . 2002;39(suppl 2):S1–S246
  26. Gratwohl A , Speck B , Wenk M , et al.   Cyclosporine in human bone marrow transplantation. Serum concentration, graft-vs-host disease, and nephrotoxicity . Transplantation . 1983;36:40–44
  27. Cogan MG , Arieff AI . Radiation nephritis and intravascular coagulation . Clin Nephrol . 1978;10:74–78
  28. Keane WF , Crosson JT , Staley NA , Anderson WR , Shapiro FL . Radiation-induced renal disease . Am J Med . 1976;60:127–137
  29. Chappell ME , Keeling M , Prentice HG , Sweny P . Hemolytic uremic syndrome after bone marrow transplantation (an adverse effect of total body irradiation) . Bone Marrow Transplant . 1988;3:339–347
  30. Phillips TL , Wharam MD , Margolis LW . Modification of radiation injury to normal tissues by chemotherapeutic agents . Cancer . 1975;35:1678–1684
  31. Luxton RW . Radiation nephritis . Q J Med . 1953;22:215–242
  32. Butcher JA , Hariharan S , Adams MB , Johnson CP , Roza AM , Cohen EP . Renal transplantation for end-stage renal disease following bone marrow transplantation (a report of six cases, with and without immunosuppression) . Clin Transplant . 1999;13:330–335
  33. Juckett MB , Cohen EP , Keever-Taylor CA , et al.   Loss of renal function following bone marrow transplantation (an analysis of angiotensin converting enzyme D/I polymorphism and other clinical risk factors) . Bone Marrow Transplant . 2001;27:451–456
  34. Go AS , Chertow GM , Fan D , McCulloch CE , Hsu CY . Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization . N Engl J Med . 2004;351:1296–1305
  35. Antignac C , Gubler MC , Leverger G , Broyer M , Habib R . Delayed renal failure with extensive mesangiolysis following bone marrow transplantation . Kidney Int . 1989;35:1336–1344
  36. Tarbell NJ , Guinan EC , Chin L , Mauch P , Weinstein HJ . Renal insufficiency after total body irradiation for pediatric bone marrow transplantation . Radiother Oncol . 1990;18(suppl 1):139–142
  37. Kist-van Holthe JE , van Zwet JML , Brand R , van Weel MH , Vossen JMJJ , van der Heijden AJ . Bone marrow transplantation in children (consequences for renal function shortly after and 1 year post-BMT) . Bone Marrow Transplant . 1998;22:559–564
  38. Chou RH , Wong GB , Kramer JH , et al.   Toxicities of total-body irradiation for pediatric bone marrow transplantation . Int J Radiat Oncol Biol Phys . 1996;34:843–851
  39. Gregoire V , Hunter N , Milas L , Brock WA , Plunkett W , Hittelman WN . Potentiation of radiation-induced regrowth delay in murine tumors by fludarabine . Cancer Res . 1994;54:468–474
  40. Gregoire V , Ang KK , Rosier JF , et al.   A phase I study of fludarabine combined with radiotherapy in patients with intermediate to locally advanced head and neck squamous cell carcinoma . Radiother Oncol . 2002;63:187–193
  41. McGinn CJ , Shewach DS , Lawrence TS . Radiosensitizing nucleosides . J Natl Cancer Inst . 1996;17:1193–1203
  42. Gregoire V , Hunter N , Brock WA , Milas L , Plunkett W , Hittelman WN . Fludarabine improves the therapeutic ratio of radiotherapy in mouse tumors after single-dose irradiation . Int J Radiat Oncol Biol Phys . 1994;30:363–371
  43. Parikh CR , Sandmaier BM , Storb RF , et al.   Acute renal failure after nonmyeloablative hematopoietic cell transplantation . J Am Soc Nephrol . 2004;15:1868–1876

PII: S1083-8791(05)00570-7

doi: 10.1016/j.bbmt.2005.08.036

Biology of Blood and Marrow Transplantation
Volume 12, Issue 1 , Pages 75-83 , January 2006