Biology of Blood and Marrow Transplantation
Volume 11, Issue 12 , Pages 945-956 , December 2005

National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: I. Diagnosis and Staging Working Group Report

  • Alexandra H. Filipovich

      Affiliations

    • Cincinnati Children’s Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio
    • Corresponding Author InformationCorrespondence and reprint requests: Alexandra H. Filipovich, MD, Division of Hematology/Oncology, Cincinnati Children’s Hospital, 333 Burnet Ave., MLC 7015, Cincinnati, OH 45229
    • ,
  • Daniel Weisdorf

      Affiliations

    • University of Minnesota, Minneapolis, Minnesota
    • ,
  • Steven Pavletic

      Affiliations

    • National Cancer Institute, National Institutes of Health, Bethesda, Maryland
    • ,
  • Gerard Socie

      Affiliations

    • Hopital Saint Louis, Paris, France
    • ,
  • John R. Wingard

      Affiliations

    • University of Florida Shands Cancer Center, Gainsville, Florida
    • ,
  • Stephanie J. Lee

      Affiliations

    • Dana-Farber Cancer Institute, Boston, Massachusetts
    • ,
  • Paul Martin

      Affiliations

    • Fred Hutchinson Cancer Research Center, University of Washington School of Medicine, Seattle, Washington
    • ,
  • Jason Chien

      Affiliations

    • Fred Hutchinson Cancer Research Center, University of Washington School of Medicine, Seattle, Washington
    • ,
  • Donna Przepiorka

      Affiliations

    • University of Tennessee, Memphis, Tennessee
    • ,
  • Daniel Couriel

      Affiliations

    • University of Texas M.D. Anderson Cancer Center, Houston, Texas
    • ,
  • Edward W. Cowen

      Affiliations

    • National Cancer Institute, National Institutes of Health, Bethesda, Maryland
    • ,
  • Patricia Dinndorf

      Affiliations

    • US Food and Drug Administration, Rockville, Maryland
    • ,
  • Ann Farrell

      Affiliations

    • US Food and Drug Administration, Rockville, Maryland
    • ,
  • Robert Hartzman

      Affiliations

    • C.W. Bill Young/Department of Defense Marrow Donor Recruitment and Research Program, Naval Medical Research Center, Silver Spring, Maryland
    • ,
  • Jean Henslee-Downey

      Affiliations

    • National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland
    • ,
  • David Jacobsohn

      Affiliations

    • Children’s Memorial Hospital, Northwestern University School of Medicine, Chicago, Illinois
    • ,
  • George McDonald

      Affiliations

    • Fred Hutchinson Cancer Research Center, University of Washington School of Medicine, Seattle, Washington
    • ,
  • Barbara Mittleman

      Affiliations

    • National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland
    • ,
  • J. Douglas Rizzo

      Affiliations

    • Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, Wisconsin
    • ,
  • Michael Robinson

      Affiliations

    • National Eye Institute, National Institutes of Health, Bethesda, Maryland
    • ,
  • Mark Schubert

      Affiliations

    • Fred Hutchinson Cancer Research Center, University of Washington School of Medicine, Seattle, Washington
    • ,
  • Kirk Schultz

      Affiliations

    • University of British Columbia, British Columbia Children’s Hospital, Vancouver, British Columbia, Canada
    • ,
  • Howard Shulman

      Affiliations

    • Fred Hutchinson Cancer Research Center, University of Washington School of Medicine, Seattle, Washington
    • ,
  • Maria Turner

      Affiliations

    • National Cancer Institute, National Institutes of Health, Bethesda, Maryland
    • ,
  • Georgia Vogelsang

      Affiliations

    • Johns Hopkins University School of Medicine, Baltimore, Maryland
    • ,
  • Mary E.D. Flowers

      Affiliations

    • Fred Hutchinson Cancer Research Center, University of Washington School of Medicine, Seattle, Washington

Received 9 September 2005 ,Accepted 9 September 2005.

References 

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  2. Shulman HM , Sullivan KM , Weiden PL , et al.   Chronic graft vs. host syndrome in man. A long-term clinicopathologic study of 20 Seattle patients . Am J Med . 1980;69:204–217
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  9. Boström L , Ringdén O , Jacobsen N , Zwaan F , Nilsson B . A European multicenter study of chronic graft-versus-host disease. The role of cytomegalovirus serology in recipients and donors—acute graft-versus-host disease, and splenectomy . Transplantation . 1990;49:1100–1105
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  12. Kondo M , Kojima S , Horibe K , Kato K , Matsuyama T . Risk factors for chronic graft-versus-host disease after allogeneic stem cell transplantation in children . Bone Marrow Transplant . 2001;27:727–730
  13. Kollman C , Howe CWS , Anasetti C , et al.   Donor characteristics as risk factors in recipients after transplantation of bone marrow from unrelated donors (the effect of donor age) . Blood . 2001;98:2043–2051
  14. Cutler C , Giri S , Jeyapalan S , Paniagua D , Viswanathan A , Antin JH . Acute and chronic graft-versus-host disease after allogeneic peripheral-blood stem-cell and bone marrow transplantation (a meta-analysis) . J Clin Oncol . 2001;19:3685–3691
  15. Przepiorka D , Anderlini P , Saliba R , et al.   Chronic graft-versus-host disease after allogeneic blood stem cell transplantation . Blood . 2001;98:1695–1700
  16. Remberger M , Kumlien G , Aschan J , et al.   Risk factors for moderate-to-severe chronic graft-versus-host disease after allogeneic hematopoietic stem cell transplantation . Biol Blood Marrow Transplant . 2002;8:674–682
  17. Randolph SSB , Gooley TA , Warren EH , Appelbaum FR , Riddell SR . Female donors contribute to a selective graft versus leukemia effect in male recipients of HLA matched related hematopoietic cell transplants . Blood . 2004;103:347–352
  18. Pavletic SZ, Carter SL, Kernan NA, et al. Influence of T-cell depletion on chronic graft-versus-host disease: results of a multi-center randomized trial in unrelated marrow donor transplantation. Blood. In press.
  19. Mielcarek M , Martin PJ , Leisenring  , et al.   Graft-versus-host disease after nonmyeloablative versus conventional hematopoietic stem cell transplantation . Blood . 2003;102:756–762
  20. Flowers MED , Parker PM , Johnston LJ , et al.   Comparison of chronic graft-versus-host disease after transplantation of peripheral blood stem cells versus bone marrow in allogeneic recipients (long-term follow-up of a randomized trial) . Blood . 2002;100:415–419
  21. Shulman HM , Sharma P , Amos D , et al.   A coded histologic study of hepatic graft-versus-host disease after human bone marrow transplantation . Hepatology . 1988;8:463–470
  22. Strasser SI , Shulman HM , Flowers ME , et al.   Chronic graft-vs-host disease of the liver (presentation as an acute hepatitis) . Hepatology . 2000;32:1265–1271
  23. Wingard JR , Piantadose S , Vogelsang GB , et al.   Predictors of death from chronic graft versus host disease after bone marrow transplantation . Blood . 1989;74:1428–1435
  24. Sullivan KM , Witherspoon RP , Storb R , et al.   Prednisone and azathioprine compared with prednisone and placebo for treatment of chronic graft-versus-host disease (prognostic influence of prolonged thrombocytopenia after allogeneic marrow transplantation) . Blood . 1988;72:546–554
  25. Lee SJ , Klein JP , Barrett AJ , et al.   Severity of chronic graft-versus-host disease (association with treatment-related mortality and relapse) . Blood . 2002;100:406–414
  26. Akpek G , Lee SJ , Flowers ME , et al.   Performance of a new clinical grading system for chronic graft-versus-host disease (a multi-center study) . Blood . 2003;102:802–809
  27. Arora M , Burns LJ , Davies SM , et al.   Chronic graft-versus-host disease (a prospective cohort study) . Biol Blood Marrow Transplant . 2003;9:38–45
  28. Stewart BL , Storer B , Storek J , et al.   Duration of immunosuppressive treatment for chronic graft-versus-host disease . Blood . 2004;104:3501–3506
  29. Parimon T , Madtes DK , Au DH , Clark JG , Chien JW . Pretransplant lung function, respiratory failure, and mortality after stem cell transplantation . Am J Respir Crit Care Med . 2005;172:384–390

 The opinions expressed here are those of the authors and do not represent the official position of the National Institutes of Health or the US Government.

PII: S1083-8791(05)00631-2

doi: 10.1016/j.bbmt.2005.09.004

Biology of Blood and Marrow Transplantation
Volume 11, Issue 12 , Pages 945-956 , December 2005

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