Biology of Blood and Marrow Transplantation
Volume 12, Issue 1, Supplement 1 , Pages 19-27 , January 2006

Genomic Polymorphism and Allogeneic Hematopoietic Transplantation Outcome

  • Charles G. Mullighan

      Affiliations

    • Department of Pathology, St. Jude Children’s Research Hospital, Memphis, Tennessee
    • Corresponding Author InformationCorrespondence and reprint requests: Charles G. Mullighan, MBBS(Hons), MSc, MD, Department of Pathology, St. Jude Children’s Research Hospital, 332 N. Lauderdale, MS #342, Memphis, TN 38105
  • ,
  • Effie W. Petersdorf

      Affiliations

    • Department of Medicine, University of Washington, and Fred Hutchinson Cancer Research Center, Seattle, Washington

Received 16 September 2005 ,Accepted 29 September 2005.

References 

  1. Petersdorf EW , Malkki M . Human leukocyte antigen matching in unrelated donor hematopoietic cell transplantation . Semin Hematol. . 2005;42:76–84
  2. Flomenberg N , Baxter-Lowe LA , Confer D , et al.   Impact of HLA class I and class II high-resolution matching on outcomes of unrelated donor bone marrow transplantation (HLA-C mismatching is associated with a strong adverse effect on transplantation outcome) . Blood . 2004;104:1923–1930
  3. Petersdorf EW , Anasetti C , Martin PJ , et al.   Limits of HLA mismatching in unrelated hematopoietic cell transplantation . Blood . 2004;104:2976–2980
  4. Farag SS , Fehniger TA , Ruggeri L , Velardi A , Caligiuri MA . Natural killer cell receptors (new biology and insights into the graft-versus-leukemia effect) . Blood . 2002;100:1935–1947
  5. Parham P , McQueen KL . Alloreactive killer cells (hindrance and help for haematopoietic transplants) . Nat Rev Immunol. . 2003;3:108–122
  6. Parham P . Immunogenetics of killer cell immunoglobulin-like receptors . Mol Immunol. . 2005;42:459–462
  7. Ruggeri L , Capanni M , Urbani E , et al.   Effectiveness of donor natural killer cell alloreactivity in mismatched hematopoietic transplants . Science . 2002;295:2097–2100
  8. Velardi A , Ruggeri L , Capanni M , et al.   Impact of NK cell alloreactivity on mismatched hematopoietic transplantation (an update on donor selection criteria and on transplantation outcomes) . [abstract] Blood . 2003;102:527
  9. Giebel S , Locatelli F , Lamparelli T , et al.   Survival advantage with KIR ligand incompatibility in hematopoietic stem cell transplantation from unrelated donors . Blood . 2003;102:814–819
  10. Bornhauser M , Schwerdtfeger R , Martin H , Frank KH , Theuser C , Ehninger G . Role of KIR ligand incompatibility in hematopoietic stem cell transplantation using unrelated donors . Blood . 2004;103:2860–2861
  11. De Santis D , Bishara A , Witt CS , et al.   Natural killer cell HLA-C epitopes and killer cell immunoglobulin-like receptors both influence outcome of mismatched unrelated donor bone marrow transplants . Tissue Antigens . 2005;65:519–528
  12. Schaffer M , Aldener-Cannava A , Remberger M , Ringden O , Olerup O . Roles of HLA-B, HLA-C and HLA-DPA1 incompatibilities in the outcome of unrelated stem-cell transplantation . Tissue Antigens . 2003;62:243–250
  13. Beelen DW , Ottinger HD , Ferencik S , et al.   Genotypic inhibitory killer immunoglobulin-like receptor ligand incompatibility enhances the long-term antileukemic effect of unmodified allogeneic hematopoietic stem cell transplantation in patients with myeloid leukemias . Blood . 2005;105:2594–2600
  14. Aversa F , Terenzi A , Tabilio A , et al.   Full haplotype-mismatched hematopoietic stem-cell transplantation (a phase II study in patients with acute leukemia at high risk of relapse) . J Clin Oncol. . 2005;23:3447–3454
  15. Cooley S, McCullar V, Wangen R, et al. KIR reconstitution is altered by T cells in the graft and correlates with clinical outcomes after unrelated donor transplantation. Blood. In press.
  16. Hsu KC , Keever-Taylor CA , Wilton A , et al.   Improved outcome in HLA-identical sibling hematopoietic stem-cell transplantation for acute myelogenous leukemia predicted by KIR and HLA genotypes . Blood . 2005;105:4878–4884
  17. Giebel S , Locatelli F , Wojnar J , et al.   Increased risk of relapse for patients undergoing HLA-C matched URD-HSCT and lacking ligands for KIR2DL2/3 . Bone Marrow Transplant. . 2005;35:S152–S153
  18. Loiseau P , Chen C , Appert M-L , et al.   The presence and number of activatory KIR (R+D−) impact the infection and survival status of patients transplanted with an HLA matched sibling donor . [abstract 3339] Blood (ASH Annual Meeting Abstracts) . 2004;104:912a
  19. Leung W , Iyengar R , Triplett B , et al.   Comparison of killer Ig-like receptor genotyping and phenotyping for selection of allogeneic blood stem cell donors . J Immunol. . 2005;174:6540–6545
  20. Cook MA , Milligan DW , Fegan CD , et al.   The impact of donor KIR and patient HLA-C genotypes on outcome following HLA-identical sibling hematopoietic stem cell transplantation for myeloid leukemia . Blood . 2004;103:1521–1526
  21. Verheyden S , Schots R , Duquet W , Demanet C . A defined donor activating natural killer cell receptor genotype protects against leukemic relapse after related HLA-identical hematopoietic stem cell transplantation . Leukemia . 2005;19:1446–1451
  22. Sun JY , Gaidulis L , Dagis A , et al.   Killer Ig-like receptor (KIR) compatibility plays a role in the prevalence of acute GVHD in unrelated hematopoietic cell transplants for AML . Bone Marrow Transplant . 2005;56:525–530
  23. Imai C , Iwamoto S , Campana D . Genetic modification of primary natural killer cells overcomes inhibitory signals and induces specific killing of leukemic cells . Blood . 2005;106:376–383
  24. Ferrara JLM , Cooke KR , Teshima T . The pathophysiology of graft-vs.-host disease . In:  Ferrara JL ,  Cooke KR ,  Deeg HJ editor. Graft-vs.-Host Disease . New York: Marcel Dekker; 2005;p. 1–34
  25. Mullighan CG , Bardy PG . Advances in the genomics of allogeneic haemopoietic stem cell transplantation . Drug Dev Res. . 2004;62:273–292
  26. Dickinson AM , Middleton PG , Rocha V , Gluckman E , Holler E . Genetic polymorphisms predicting the outcome of bone marrow transplants . Br J Haematol. . 2004;127:479–490
  27. Mullighan CG , Heatley S , Doherty K , et al.   Mannose-binding lectin gene polymorphisms are associated with major infection following allogeneic hemopoietic stem cell transplantation . Blood . 2002;99:3524–3529
  28. Rocha V , Franco RF , Porcher R , et al.   Host defense and inflammatory gene polymorphisms are associated with outcomes after HLA-identical sibling bone marrow transplantation . Blood . 2002;100:3908–3918
  29. Mohty M , Gaugler B , Faucher C , et al.   The “cytokine storm” at the era of reduced intensity conditioning allogeneic stem cell transplantation . Bone Marrow Transplant . 2005;35:S79–S80

PII: S1083-8791(05)00667-1

doi: 10.1016/j.bbmt.2005.09.014

Biology of Blood and Marrow Transplantation
Volume 12, Issue 1, Supplement 1 , Pages 19-27 , January 2006