Biology of Blood and Marrow Transplantation
Volume 12, Issue 2 , Pages 152-159 , February 2006

Skin Explant Model of Human Graft-versus-Host Disease: Prediction of Clinical Outcome and Correlation with Biological Risk Factors

  • Xiao-nong Wang

      Affiliations

    • Haematological Sciences, Medical School, University of Newcastle upon Tyne, Newcastle upon Tyne, United Kingdom
    • Corresponding Author InformationCorrespondence and reprint requests: Xiao-nong Wang, PhD, Haematological Sciences, Leech Building, Medical School, University of Newcastle upon Tyne, Newcastle upon Tyne, NE2 4HH, UK
    • ,
  • Matthew Collin

      Affiliations

    • Haematological Sciences, Medical School, University of Newcastle upon Tyne, Newcastle upon Tyne, United Kingdom
    • ,
  • Lisbet Sviland

      Affiliations

    • Department of Pathology, The Gade Institute, Haukeland Hospital, Bergen, Norway
    • ,
  • Scott Marshall

      Affiliations

    • Haematological Sciences, Medical School, University of Newcastle upon Tyne, Newcastle upon Tyne, United Kingdom
    • ,
  • Graham Jackson

      Affiliations

    • Haematology, Royal Victoria Infirmary, Newcastle upon Tyne, United Kingdom
    • ,
  • Ute Schulz

      Affiliations

    • Department of Haematology and Oncology, University of Regensburg, Regensburg, Germany
    • ,
  • Ernst Holler

      Affiliations

    • Department of Haematology and Oncology, University of Regensburg, Regensburg, Germany
    • ,
  • Sigrid Karrer

      Affiliations

    • Department of Dermatology, University of Regensburg, Regensburg, Germany
    • ,
  • Hildegard Greinix

      Affiliations

    • Department of Internal Medicine I, Medical University of Vienna, Vienna, Austria
    • ,
  • Fariborz Elahi

      Affiliations

    • Department of Internal Medicine I, Medical University of Vienna, Vienna, Austria
    • ,
  • Ilona Hromadnikova

      Affiliations

    • Second Medical Faculty, Charles University, Prague, Czech Republic
    • ,
  • A.M. Dickinson

      Affiliations

    • Haematological Sciences, Medical School, University of Newcastle upon Tyne, Newcastle upon Tyne, United Kingdom

Received 5 September 2005 ,Accepted 26 September 2005.

  • Image Result

    Histopathologic changes for different grades of skin GVHR. A, Grade I skin GVHR showing very mild vacuolization of epidermal cells. B, Grade II skin GVHR showing diffuse vacuolization of epidermal cel

    Histopathologic changes for different grades of skin GVHR. A, Grade I skin GVHR showing very mild vacuolization of epidermal cells. B, Grade II skin GVHR showing diffuse vacuolization of epidermal cells. C, Grade III skin GVHR showing cleft formation between the epidermis and dermis caused by confluent vacuolar damage to basal keratinocytes. D, Grade IV skin GVHR showing the complete separation of the epidermis and dermis.

  • Image Result
    Association of skin GVHR grade with HLA matching status, sex combinations, and patient age. In Figure 2A, a, b, and c represent HLA-matched related, HLA-matched unrelated, and HLA-unmatched unrelated

    Association of skin GVHR grade with HLA matching status, sex combinations, and patient age. In Figure 2A, a, b, and c represent HLA-matched related, HLA-matched unrelated, and HLA-unmatched unrelated allopairs, respectively.

PII: S1083-8791(05)00671-3

doi: 10.1016/j.bbmt.2005.09.018

Biology of Blood and Marrow Transplantation
Volume 12, Issue 2 , Pages 152-159 , February 2006

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