Biology of Blood and Marrow Transplantation
Volume 12, Issue 2 , Pages 184-194 , February 2006

Results of the Cord Blood Transplantation Study (COBLT): Outcomes of Unrelated Donor Umbilical Cord Blood Transplantation in Pediatric Patients with Lysosomal and Peroxisomal Storage Diseases

  • Paul L. Martin

      Affiliations

    • Duke University Medical Center, Durham, North Carolina
    • ,
  • Shelly L. Carter

      Affiliations

    • The EMMES Corporation, Rockville, Maryland
    • ,
  • Nancy A. Kernan

      Affiliations

    • Memorial Sloan-Kettering Cancer Center, New York, New York
    • ,
  • Indira Sahdev

      Affiliations

    • Schneider Children’s Hospital, New Hyde Park, New York
    • ,
  • Donna Wall

      Affiliations

    • Texas Transplant Institute, San Antonio, Texas
    • ,
  • Daniel Pietryga

      Affiliations

    • DeVos Children’s Hospital, Grand Rapids, Michigan
    • ,
  • John E. Wagner

      Affiliations

    • University of Minnesota, Minneapolis, Minnesota
    • ,
  • Joanne Kurtzberg

      Affiliations

    • Duke University Medical Center, Durham, North Carolina
    • Corresponding Author InformationCorrespondence and reprint requests: Joanne Kurtzberg, MD, Duke University Medical Center, Box 3350, Durham, NC 27710

Received 19 May 2005 ,Accepted 23 September 2005.

  • Image Result

    Survival for patients with lysosomal diseases. A, Overall survival. B, Survival by recipient race. C, Survival by study cohort (LSD stratum versus EAP). D, Survival by final HLA match.

    Survival for patients with lysosomal diseases. A, Overall survival. B, Survival by recipient race. C, Survival by study cohort (LSD stratum versus EAP). D, Survival by final HLA match.

  • Image Result

    Cumulative incidence (CINC) of engraftment and GVHD. A, CINC and 1 − KM probability of neutrophil engraftment. B, CINC and 1 − KM probability of a platelet engraftment of 50000. C, CINC and 1 − KM pro

    Cumulative incidence (CINC) of engraftment and GVHD. A, CINC and 1 − KM probability of neutrophil engraftment. B, CINC and 1 − KM probability of a platelet engraftment of 50000. C, CINC and 1 − KM probability of acute GVHD. D, CINC and 1 − KM probability of chronic GVHD.

  • Image Result
    Transplant-related toxicity. Maximal toxicity by organ system is shown through day 42 as graded by the Bearman toxicity scale [28]. The maximum toxicity experienced in any organ system was 1 (1%) grad

    Transplant-related toxicity. Maximal toxicity by organ system is shown through day 42 as graded by the Bearman toxicity scale [28]. The maximum toxicity experienced in any organ system was 1 (1%) grade 0, 5 (7%) grade 1, 47 (68%) grade 2, 15 (22%) grade 3, and 1 (1%) grade 4. CNS, central nervous system; GI, gastrointestinal.

PII: S1083-8791(05)00672-5

doi: 10.1016/j.bbmt.2005.09.016

Biology of Blood and Marrow Transplantation
Volume 12, Issue 2 , Pages 184-194 , February 2006

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