Biology of Blood and Marrow Transplantation
Volume 12, Issue 2 , Pages 204-216 , February 2006

Pretransplantation Consolidation Chemotherapy Decreases Leukemia Relapse after Autologous Blood and Bone Marrow Transplants for Acute Myelogenous Leukemia in First Remission

  • Martin S. Tallman

      Affiliations

    • Northwestern University Medical School, Chicago, Illinois
    • ,
  • Waleska S. Pérez

      Affiliations

    • Autologous Blood and Marrow Transplant Registry (ABMTR) Health Policy Institute, Medical College of Wisconsin, Milwaukee, Wisconsin
    • ,
  • Hillard M. Lazarus

      Affiliations

    • University Hospitals of Cleveland, Ireland Cancer Center, Cleveland, Ohio
    • ,
  • Robert Peter Gale

      Affiliations

    • Center for Advanced Studies in Leukemia, Los Angeles, California
    • ,
  • Richard T. Maziarz

      Affiliations

    • Oregon Health and Science University, Portland, Oregon
    • ,
  • Jacob M. Rowe

      Affiliations

    • Rambam Medical Center and Technion, Haifa, Israel
    • ,
  • David I. Marks

      Affiliations

    • Bristol Children’s Hospital, Bristol, U.K
    • ,
  • Jean-Yves Cahn

      Affiliations

    • Hopital Jean Minijoz, Besancon Cedex, France
    • ,
  • Asad Bashey

      Affiliations

    • University of California, San Diego, La Jolla, California
    • ,
  • Michael R. Bishop

      Affiliations

    • National Cancer Institute, Bethesda, Maryland
    • ,
  • Neal Christiansen

      Affiliations

    • University of South Carolina, Columbia, South Carolina
    • ,
  • Stanley R. Frankel

      Affiliations

    • Merck Research Labs, Blue Bell, Pennsylvania
    • ,
  • Juan J. García

      Affiliations

    • Hospital Privado de Cordoba, Cordoba, Peia, Argentina
    • ,
  • Osman Ilhan

      Affiliations

    • Ibini Sinai Hospital, Ankara, Turkey
    • ,
  • Mary J. Laughlin

      Affiliations

    • University Hospitals of Cleveland, Ireland Cancer Center, Cleveland, Ohio
    • ,
  • Jane Liesveld

      Affiliations

    • University of Rochester Medical Center, Rochester, New York
    • ,
  • Charles Linker

      Affiliations

    • University of California San Francisco Medical Center, San Francisco, California
    • ,
  • Mark R. Litzow

      Affiliations

    • Mayo Clinic and Foundation, Rochester, Minnesota
    • ,
  • Selina Luger

      Affiliations

    • University of Pennsylvania Hospital, Philadelphia, Pennsylvania
    • ,
  • Philip L. McCarthy

      Affiliations

    • Roswell Park Cancer Institute, Buffalo, New York
    • ,
  • Gustavo A. Milone

      Affiliations

    • Angélica Ocampo-Hospital and Research Center-Fundaleu, Buenos Aires, Argentina
    • ,
  • Santiago Pavlovsky

      Affiliations

    • Angélica Ocampo-Hospital and Research Center-Fundaleu, Buenos Aires, Argentina
    • ,
  • Gordon L. Phillips

      Affiliations

    • Greenbaum Cancer Center, Baltimore, Maryland
    • ,
  • James A. Russell

      Affiliations

    • Tom Baker Cancer Institute, Calgary, Alberta, Canada
    • ,
  • Ruben A. Saez

      Affiliations

    • Watson Clinic, LLP, Lakeland, Florida
    • ,
  • Gary Schiller

      Affiliations

    • University of California Los Angeles Center for Health Sciences, Los Angeles, California
    • ,
  • Jorge Sierra

      Affiliations

    • Hospital Sant Pau, Barcelona, Spain
    • ,
  • Roy S. Weiner

      Affiliations

    • Tulane University Medical Center, New Orleans, Louisiana
    • ,
  • Axel R. Zander

      Affiliations

    • Universitats-Krankenhaus Eppendorg, Hamburg, Germany; University of Toronto, Toronto, Canada
    • ,
  • Mei-Jie Zhang

      Affiliations

    • Autologous Blood and Marrow Transplant Registry (ABMTR) Health Policy Institute, Medical College of Wisconsin, Milwaukee, Wisconsin
    • ,
  • Armand Keating

      Affiliations

    • University of Minnesota, Minneapolis, Minnesota
    • ,
  • Daniel J. Weisdorf

      Affiliations

    • University of Minnesota, Minneapolis, Minnesota
    • ,
  • Mary M. Horowitz

      Affiliations

    • Autologous Blood and Marrow Transplant Registry (ABMTR) Health Policy Institute, Medical College of Wisconsin, Milwaukee, Wisconsin
    • Corresponding Author InformationCorrespondence and reprint requests: Mary M. Horowitz, MD, MS, Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, 8701 Watertown Plank Road, P.O. Box 26509, Milwaukee, WI 53226

Received 1 April 2005 ,Accepted 3 October 2005.

References 

  1. Cassileth PA , Andersen J , Lazarus HM , et al.   Autologous bone marrow transplant in acute myeloid leukemia in first remission . J Clin Oncol . 1993;11:314–319
  2. Sierra J , Granena A , Garcia J , et al.   Autologous bone marrow transplantation for acute leukemia (results and prognostic factors in 90 consecutive patients) . Bone Marrow Transplant . 1993;12:517–523
  3. Schiller G , Lee M , Miller T , et al.   Transplantation of autologous peripheral blood progenitor cells procured after high-dose cytarabine-based consolidation chemotherapy for adults with acute myelogenous leukemia in first remission . Leukemia . 1997;11:1533–1539
  4. Gondo H , Haranda M , Miyamoto T , et al.   Autologous peripheral blood stem cell transplantation for acute myelogenous leukemia . Bone Marrow Transplant . 1997;20:821–826
  5. Burnett AK , Goldstone AH , Stevens RM , et al.  UK Medical Research Council Adult and Childrens Leukemia Working Parties   Randomized comparison of addition of autologous bone-marrow transplantation to intensive chemotherapy for acute myeloid leukemia in first remission (results of MRC AML 10 trial) . Lancet . 1998;351:700–708
  6. Visani G , Lemoli R , Tosi P , et al.   Use of peripheral blood stem cells for autologous transplantation in acute myeloid leukemia patients allows faster engraftment and equivalent disease-free survival compared to bone marrow cells . Bone Marrow Transplant . 1999;24:467–472
  7. Gulati S , Acaba L , Yahalom J , et al.   Autologous bone marrow transplantation for acute myelogenous leukemia using 4-hydroperoxycyclophosphamide and VP-16 purged bone marrow . Bone Marrow Transplant . 1992;10:129–134
  8. Selvaggi KJ , Wilson JW , Mills LE , et al.   Improved outcome for high-risk acute myeloid leukemia patients using autologous bone marrow transplantation and monoclonal antibody-purged bone marrow . Blood . 1994;83:1698–1705
  9. Ball ED , Wilson J , Phelphs V , et al.   Autologous bone marrow transplantation for acute myeloid leukemia in remission or first relapse using monoclonal antibody-purged marrow (results of phase II studies with long-term follow-up) . Bone Marrow Transplant . 2000;25:823–829
  10. Schiller G , Wong S , Lowe T , et al.   Transplantation of IL-2–mobilized autologous peripheral blood progenitor cells for adults with acute myelogenous leukemia in first remission . Leukemia . 2001;15:757–763
  11. Benyunes MC , Massumoto C , York A , et al.   Interleukin-2 with or without lymphokine-activated killer cells as consolidative immunotherapy after autologous bone marrow transplantation for acute myelogenous leukemia . Bone Marrow Transplant . 1993;12;:159–163
  12. Vivancos P , Granena A , Sarra J , et al.   Treatment with interleukin-2 (IL-2) and interferon (IFNalpha2b) after autologous bone marrow or peripheral blood stem cell transplantation in onco-hematological malignancies with a high risk of relapse . Bone Marrow Transplant . 1999;23:169–172
  13. Isnard F , Guiguet M , Laporte JP , et al.   Improved efficiency of remission induction facilitates autologous BMT harvesting and improves overall survival in adults with AML (108 patients treated at a single institution) . Bone Marrow Transplant . 2001;27:1045–1052
  14. Tallman MS , Rowlings PA , Milone G , et al.   Effect of postremission chemotherapy before human leukocyte antigen-identical sibling transplantation for acute myelogenous leukemia in first complete remission . Blood . 2000;96:1254–1258
  15. Gale RP , Horowitz MM , Weiner RS , et al.   Impact of cytogenetic abnormalities in outcome of bone marrow transplants in acute myelogenous leukemia in first remission . Bone Marrow Transplant . 1995;16:203–208
  16. Gooley TA , Leisenring W , Crowley J , et al.   Estimation of failure probabilities in the presence of competing risks (new representations of old estimators) . Stat Med . 1999;18:695–706
  17. Klein JP , Moeschberger ML . In: Survival Analysis (Techniques for Censored and Truncated Data) . New York: Springer-Verlag; 1996;p. 334–336
  18. Andersen PK , Klein JP , Zhang MJ . Testing for centre effects in multi-centre survival studies (a Monte Carlo comparison of fixed and random effects tests) . Stat Med . 1999;18:1489–1500
  19. Mehta J , Powles R , Singhal S , et al.   Autologous bone marrow transplantation for acute myeloid leukemia in first remission (identification of modifiable prognostic factors) . Bone Marrow Transplant . 1995;16:499–506
  20. Cahn JY , Labopin M , Sierra J , et al.   No impact of high-dose cytarabine on the outcome of patients transplanted for acute myeloblastic leukemia in first remission . Br J Haematol . 2000;110:308–314
  21. Cassileth PA , Lee SJ , Miller KB , et al.   Feasibility study of adding high-dose cytarabine (HDAC) in induction (IND) and in consolidation (CONS) therapy before autologous stem cell transplant (ASCT) in adult acute myeloid leukemia (AML) . [abstract] Blood . 1998;92:362b
  22. Byrd JC , Dodge RK , Carroll A , et al.   Patients with t(8;21)(q22;q22) and acute myeloid leukemia have superior failure-free and overall survival when repetitive cycles of high-dose cytarabine are administered . J Clin Oncol . 1999;17:3767–3775
  23. Bloomfield CD , Lawrence D , Byrd JC , et al.   Frequency of prolonged remission duration after high-dose cytarabine intensification in acute myeloid leukemia varies by cytogenetic subtype . Cancer Res . 1998;58:4173–4179
  24. Reiffers J , Labopin M , Sanz M , et al.   Autologous blood cell vs marrow transplantation for acute myeloid leukemia in complete remission (an EBMT retrospective analysis) . Bone Marrow Transplant . 2000;25:1115–1119

PII: S1083-8791(05)00683-X

doi: 10.1016/j.bbmt.2005.10.013

Biology of Blood and Marrow Transplantation
Volume 12, Issue 2 , Pages 204-216 , February 2006

Article Tools

* Image Usage & Resolution