Biology of Blood and Marrow Transplantation
Volume 12, Issue 1, Supplement 1 , Pages 42-46 , January 2006

Immune Reconstitution: From Stem Cells to Lymphocytes

  • Gay M. Crooks

      Affiliations

    • Divisions of Research Immunology and Bone Marrow Transplant, Children’s Hospital Los Angeles, Los Angeles, California
    • ,
  • Kenneth Weinberg

      Affiliations

    • Divisions of Research Immunology and Bone Marrow Transplant, Children’s Hospital Los Angeles, Los Angeles, California
    • Corresponding Author InformationCorrespondence and reprint requests: Kenneth Weinberg, MD, Division of Pediatric Stem Cell Transplantation, Lucile Packard Children’s Hospital, 1000 Welch Rd., Stanford, CA 94305
    • ,
  • Crystal Mackall

      Affiliations

    • Pediatric Oncology Branch, National Cancer Institute, Bethesda, Maryland

References 

  1. Ochs L , Shu XO , Miller J , et al.   Late infections after allogeneic bone marrow transplantations (comparison of incidence in related and unrelated donor transplant recipients) . Blood . 1995;86:3979–3986
  2. Small TN , Papadopoulos EB , Boulad F , et al.   Comparison of immune reconstitution after unrelated and related T-cell-depleted bone marrow transplantation (effect of patient age and donor leukocyte infusions) . Blood . 1999;93:467–480
  3. Weinberg K , Blazar BR , Wagner JE , et al.   Factors affecting thymic function after allogeneic hematopoietic stem cell transplantation . Blood . 2001;97:1458–1466
  4. Hakim FT , Memon SA , Cepeda R , et al.   Age-dependent incidence, time course, and consequences of thymic renewal in adults . J Clin Invest. . 2005;115:930–939
  5. Mackall CL , Bare CV , Granger LA , et al.   Thymic-independent T cell regeneration occurs via antigen-driven expansion of peripheral T cells resulting in a repertoire that is limited in diversity and prone to skewing . J Immunol. . 1996;156:4609–4616
  6. Kondo M , Weissman IL , Akashi K . Identification of clonogenic common lymphoid progenitors in mouse bone marrow . Cell . 1997;91:661–672
  7. Hao QL , Zhu J , Price MA , et al.   Identification of a novel, human multilymphoid progenitor in cord blood . Blood . 2001;97:3683–3690
  8. Arber C , BitMansour A , Sparer TE , et al.   Common lymphoid progenitors rapidly engraft and protect against lethal murine cytomegalovirus infection after hematopoietic stem cell transplantation . Blood . 2003;102:421–428
  9. Kong FK , Chen CL , Cooper MD . Reversible disruption of thymic function by steroid treatment . J Immunol. . 2002;168:6500–6505
  10. Bolotin E , Smith S , Smogorewska EM , Widmer M , Weinberg KI . Enhancement of thymopoiesis after bone marrow transplant by in vivo IL-7 . Blood . 1996;88:1887–1894
  11. Min D , Taylor PA , Panoskaltsis-Mortari A , et al.   Protection from thymic epithelial cell injury by keratinocyte growth factor (a new approach to improve thymic and peripheral T-cell reconstitution after bone marrow transplantation) . Blood . 2002;99:4592–4600
  12. Guimond M , Fry TJ , Mackall CL . Cytokine signals in T-cell homeostasis . J Immunother. . 2005;28:289–294
  13. Watanabe N , Hanabuchi S , Soumelis V , et al.   Human thymic stromal lymphopoietin promotes dendritic cell-mediated CD4+ T cell homeostatic expansion . Nat Immunol. . 2004;5:426–434

PII: S1083-8791(05)00720-2

doi: 10.1016/j.bbmt.2005.10.015

Biology of Blood and Marrow Transplantation
Volume 12, Issue 1, Supplement 1 , Pages 42-46 , January 2006

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