Adenoviral Infections in Hematopoietic Stem Cell Transplantation

Adenovirus life cycle. Infection is a multistage process involving adsorption, internalization, virus uncoating and virion antigen presentation, trafficking to the nucleus, viral replication, and finally host cell lysis and virus escape. The figure indicates that virus uncoating and antigen presentation may occur before the expression of the immune evasion genes, which occurs in a temporal fashion after viral DNA entry into the nucleus. Thus the infected cell may be sensitive to lysis by virion-specific T cells before its production and the release of new infectious virions.