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Biology of Blood and Marrow Transplantation
Volume 12, Issue 2
, Pages 160-171
, February 2006
Impaired Allogeneic Activation and T-helper 1 Differentiation of Human Cord Blood Naive CD4 T Cells
References
- . The pathophysiology of acute graft-versus-host disease . Int J Hematol . 2003;78:181–187
- . Graft-versus-host disease (how to translate new insights into new therapeutic strategies) . Biol Blood Marrow Transplant . 2004;10:815–825
- Leukocyte migration and graft-versus-host disease . Blood . 2005;105:4191–4199
- Host dendritic cells alone are sufficient to initiate acute graft-versus-host disease . J Immunol . 2004;172:7393–7398
- Memory CD4+ T cells do not induce graft-versus-host disease . J Clin Invest . 2003;112:101–108
- Human CD62L- memory T cells are less responsive to alloantigen stimulation than CD62L+ naive T cells (potential for adoptive immunotherapy and allodepletion) . Blood . 2004;104:2403–2409
- In vivo analyses of early events in acute graft-versus-host disease reveal sequential infiltration of T-cell subsets . Blood . 2005;106:1113–1122
- Acute graft-versus-host disease does not require alloantigen expression on host epithelium . Nat Med . 2002;8:575–581
- Th1 and Th2 mediate acute graft-versus-host disease, each with distinct end-organ targets . J Clin Invest . 2000;105:1289–1298
- Transplants of umbilical-cord blood or bone marrow from unrelated donors in adults with acute leukemia . N Engl J Med . 2004;351:2276–2285
- Outcomes after transplantation of cord blood or bone marrow from unrelated donors in adults with leukemia . N Engl J Med . 2004;351:2265–2275
- Longitudinal survey of lymphocyte subpopulations in the first year of life . Pediatr Res . 2000;47:528–537
- Unique patterns of surface receptors, cytokine secretion, and immune functions distinguish T cells in the bone marrow from those in the periphery (impact on allogeneic bone marrow transplantation) . Blood . 2002;99:1449–1457
- . Genetic dissection of immunity to mycobacteria (the human model) . Annu Rev Immunol . 2002;20:581–620
- . T-cell activation through the antigen receptor. Part 1: signaling components, signaling pathways, and signal integration at the T-cell antigen receptor synapse . J Allergy Clin Immunol . 2002;109:758–770
- . Dendritic cells (specialized and regulated antigen processing machines) . Cell . 2001;106:255–258
- . Interleukin-12 and the regulation of innate resistance and adaptive immunity . Nat Rev Immunol . 2003;3:133–146
- Role of T-bet in commitment of TH1 cells before IL-12-dependent selection . Science . 2001;292:1907–1910
- Signaling by IL-12 and IL-23 and the immunoregulatory roles of STAT4 . Immunol Rev . 2004;202:139–156
- . Issues in T-helper 1 development–resolved and unresolved . Immunol Rev . 2004;202:157–174
- Molecular mechanisms regulating Th1 immune responses . Annu Rev Immunol . 2003;21:713–758
- . Natural regulatory T cells and self-tolerance . Nat Immunol . 2005;6:327–330
- . Natural regulatory T cells in infectious disease . Nat Immunol . 2005;6:353–360
- . Foxp3 programs the development and function of CD4+CD25+ regulatory T cells . Nat Immunol . 2003;4:330–336
- . Control of regulatory T cell development by the transcription factor Foxp3 . Science . 2003;299:1057–1061
- CD25+CD4+ T cells in human cord blood (an immunoregulatory subset with naive phenotype and specific expression of forkhead box p3 (Foxp3) gene) . Exp Hematol . 2004;32:622–629
- CD4+ CD25+ FOXP3+ regulatory T cells from human thymus and cord blood suppress antigen-specific T cell responses . Immunology . 2005;115:516–525
- Cord blood CD4(+)CD25(+)-derived T regulatory cell lines express FoxP3 protein and manifest potent suppressor function . Blood . 2005;105:750–758
- CD4 T cell activation by myelin oligodendrocyte glycoprotein is suppressed by adult but not cord blood CD25+ T cells . Eur J Immunol . 2003;33:579–587
- Undetectable CD40 ligand expression on T cells and low B cell responses to CD40 binding agonists in human newborns . J Immunol . 1995;154:1560–1568
- . Decreased expression of the ligand for CD40 in newborn lymphocytes . Eur J Immunol . 1994;24:1925–1928
- Diminished expression of CD40 ligand by activated neonatal T cells . J Clin Invest . 1995;95:66–75
- Decreased CD154 expression by neonatal CD4+ T cells is due to limitations in both proximal and distal events of T cell activation . Int Immunol . 2003;15:1461–1472
- Sustained expression of CD154 (CD40L) and proinflammatory cytokine production by alloantigen-stimulated umbilical cord blood T cells . J Immunol . 2000;164:6206–6212
-
.
Tolerance associated with cord blood transplantation may depend on the state of the host dendritic cells
.
Br J Hematol
. 2004;126:517–526
- CD40 ligand is expressed and functional on activated neonatal T cells . J Immunol . 1996;156:119–127
- Decreased interleukin-12 (IL-12) from activated cord versus adult peripheral blood mononuclear cells and upregulation of interferon-gamma, natural killer, and lymphokine-activated killer activity by IL-12 in cord blood mononuclear cells . Blood . 1996;88:945–954
- . Rapid conversion of naive to effector T cell function counteracts diminished primary human newborn T cell responses . Clin Exp Immunol . 1999;116:527–533
-
.
Developmental immunology and role of host defenses in the fetal and neonatal susceptibility to infection
.
In:
Remington JS
, Klein JO
, Wilson CB
editor.
Infectious Diseases of the Fetus and Newborn Infant
. 6th ed.. Philadelphia, PA: Elsevier; 2005;p. 87–210
- Impaired accumulation and function of memory CD4 T cells in human IL-12 receptor beta 1 deficiency . J Immunol . 2003;170:597–603
- Persistent and selective deficiency of CD4+ T cell immunity to cytomegalovirus in immunocompetent young children . J Immunol . 2004;172:3260–3267
- Detection of intracellular phosphorylated STAT-4 by flow cytometry . Clin Immunol . 2001;100:270–276
- . The activation antigen CD69 . Stem Cells . 1994;12:456–465
- CD40/CD154 interactions at the interface of tolerance and immunity . Annu Rev Immunol . 2004;22:307–328
- . NFAT signaling (choreographing the social lives of cells) . Cell . 2002;109(suppl):S67–S79
- IFN-gamma production by antigen-presenting cells (mechanisms emerge) . Trends Immunol . 2001;22:556–560
- Maturation of human neonatal CD4+ and CD8+ T lymphocytes into Th1/Th2 effectors . Vaccine . 1998;16:1415–1419
- Interleukin-10 and the interleukin-10 receptor . Annu Rev Immunol . 2001;19:683–765
- Defective antigen-induced lymphocyte proliferation in the X-linked hyper-IgM syndrome . [see comments] J Pediatr . 1997;131:147–150
- The umbilical cord blood alpha/beta T-cell repertoire (characteristics of a polyclonal and naive but completely formed repertoire) . Blood . 1998;91:340–346
- . Signaling control of memory T cell generation and function . Semin Immunol . 2004;16:285–293
- Expression of the leukocyte early activation antigen CD69 is regulated by the transcription factor AP-1 . J Immunol . 1997;159:5463–5473
- Regulation of T cell receptor-induced activation of the Ras-ERK pathway by diacylglycerol kinase zeta . J Biol Chem . 2002;277:31089–31098
- Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity (T-T help via APC activation) . J Exp Med . 1996;184:747–752
- Cutting edge (sustained expansion of CD8+ T cells requires CD154 expression by Th cells in acute graft versus host disease) . J Immunol . 1999;162:4373–4376
- Reduced expression of NFAT-associated genes in UCB versus adult CD4+ T lymphocytes during primary stimulation . Blood . 2003;102:4608–4617
- A CD4+ T-cell subset inhibits antigen-specific T-cell responses and prevents colitis . Nature . 1997;389:737–742
- Interleukin-10 dose-dependent regulation of CD4+ and CD8+ T cell-mediated graft-versus-host disease . Transplantation . 1998;66:1220–1229
- . Interleukin 10, produced in abundance by human newborn T cells, may be the regulator of increased tolerance associated with cord blood stem cell transplantation . Br J Haematol . 2002;116:702–709
- Interleukin-10 inhibits expression of both interferon alpha- and interferon gamma- induced genes by suppressing tyrosine phosphorylation of STAT1 . Blood . 1999;93:1456–1463
- Diminished interferon-gamma and lymphocyte proliferation in neonatal and postpartum primary herpes simplex virus infection . J Infect Dis . 1992;165:813–818
- . What do TCR-pMHC crystal structures teach us about MHC restriction and alloreactivity? . Trends Immunol . 2003;24:429–437
PII: S1083-8791(05)00728-7
doi: 10.1016/j.bbmt.2005.10.027
© 2006 American Society for Blood and Marrow Transplantation. Published by Elsevier Inc. All rights reserved.
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Biology of Blood and Marrow Transplantation
Volume 12, Issue 2
, Pages 160-171
, February 2006
