Biology of Blood and Marrow Transplantation
Volume 12, Issue 5 , Pages 560-565 , May 2006

Thymoglobulin Prevents Chronic Graft-versus-Host Disease, Chronic Lung Dysfunction, and Late Transplant-Related Mortality: Long-Term Follow-Up of a Randomized Trial in Patients Undergoing Unrelated Donor Transplantation

  • Andrea Bacigalupo

      Affiliations

    • Divisione di Ematologia, Ospedale San Martino, Genova
    • Corresponding Author InformationCorrespondence and reprint requests: Andrea Bacigalupo, MD, Divisione Ematologia 2 (PAD 6/I), Ospedale San Martino, Largo Rosanna Benzi 10, 16132 Genova, Italy
    • ,
  • Teresa Lamparelli

      Affiliations

    • Divisione di Ematologia, Ospedale San Martino, Genova
    • ,
  • Giovanni Barisione

      Affiliations

    • U.O. Medicina Preventiva e del Lavoro Laboratorio di Fisiopatologia Respiratoria, Ospedale San Martino, Genova
    • ,
  • Paolo Bruzzi

      Affiliations

    • IST, Ospedale San Martino, Genova
    • ,
  • Stefano Guidi

      Affiliations

    • Dipartimento di Ematologia Ospedale di Careggi, Firenze
    • ,
  • Paolo Emilio Alessandrino

      Affiliations

    • Dipartimento di Ematologia, Policlinico San Matteo, Pavia
    • ,
  • Paolo di Bartolomeo

      Affiliations

    • Dipartimento di Ematologia, Ospedale Civille, Pescara
    • ,
  • Rosi Oneto

      Affiliations

    • Divisione di Ematologia, Ospedale San Martino, Genova
    • ,
  • Barbara Bruno

      Affiliations

    • Divisione di Ematologia, Ospedale San Martino, Genova
    • ,
  • Nicoletta Sacchi

      Affiliations

    • IBMDR, Ospedale Galliera, Genova, Italy
    • ,
  • Maria Teresa van Lint

      Affiliations

    • Divisione di Ematologia, Ospedale San Martino, Genova
    • ,
  • Alberto Bosi

      Affiliations

    • IST, Ospedale San Martino, Genova
    • ,
  • Gruppo Italiano Trapianti Midollo Osseo (GITMO)

Received 31 August 2005 ,Accepted 15 December 2005.

References 

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  2. Goerner M , Gooley T , Flowers ME , et al.   Morbidity and mortality of chronic GVHD after hematopoietic stem cell transplantation from HLA-identical siblings for patients with aplastic or refractory anemias . Biol Blood Marrow Transplant . 2002;8:47–56
  3. Weisdorf DJ , Anasetti C , Antin JH , et al.   Allogeneic bone marrow transplantation for chronic myelogenous leukemia (comparative analysis of unrelated versus matched sibling donor transplantation) . Blood . 2002;99:1971–1977
  4. Duggan P , Booth K , Chaudhry A , et al.   Unrelated donor BMT recipients given pretransplant low-dose antithymocyte globulin have outcomes equivalent to matched sibling BMT (a matched pair analysis) . Bone Marrow Transplant . 2002;30:681–686
  5. Finke J , Bertz H , Schmoor C , et al.   Allogeneic bone marrow transplantation from unrelated donors using in vivo anti-T-cell globulin . Br J Haematol . 2000;111:303–313
  6. Remberger M , Storer B , Ringden O , Anasetti C . Association between pretransplant Thymoglobulin and reduced non-relapse mortality rate after marrow transplantation from unrelated donors . Bone Marrow Transplant . 2002;29:391–397
  7. Kroger N , Zabelina T , Kruger W , et al.   In vivo T cell depletion with pretransplant anti-thymocyte globulin reduces graft-versus-host disease without increasing relapse in good risk myeloid leukemia patients after stem cell transplantation from matched related donors . Bone Marrow Transplant . 2002;29:683–689
  8. Zander AR , Kroger N , Schleuning M , et al.   ATG as part of the conditioning regimen reduces transplant related mortality (TRM) and improves overall survival after unrelated stem cell transplantation in patients with chronic myeloid leukemia . Bone Marrow Transplant . 2003;32:355–361
  9. Bacigalupo A , Lamparelli T , Gualandi F , et al.   Prophylactic antithymocyte globulin reduces the risk of chronic graft-versus-host disease in alternative-donor bone marrow transplants . Biol Blood Marrow Transplant . 2002;8:656–661
  10. Bacigalupo A . Antilymphocyte globulin for graft versus host disease prophylaxis (efficacy and side effects) . Bone Marrow Transplant . 2005;35:225–231
  11. Weiden PL , Doney K , Storb R , Thomas ED . Antihuman thymocyte globulin for prophylaxis of graft-versus-host disease. A randomized trial in patients with leukemia treated with HLA-identical sibling marrow grafts . Transplantation . 1979;27:227–230
  12. Ramsay NKC , Kersey JH , Robinson LL , et al.   A randomized study of the prevention of acute graft versus host disease . N Engl J Med . 1982;306:392–397
  13. Bacigalupo A , Lamparelli T , Bruzzi P , et al.   Antithymocyte globulin for graft-versus-host disease prophylaxis in transplants from unrelated donors (2 randomized studies from Gruppo Italiano Trapianti Midollo Osseo (GITMO)) . Blood . 2001;98:2942–2947
  14. Shulman HM , Sullivan KM , Weiden PL , et al.   Chronic graft-versus-host syndrome in man. A long-term clinicopathologic study of 20 Seattle patients . Am J Med . 1980;69:204–217
  15. Ferrara JLM , Cooke KR , Deeg HJ . Graft-vs-Host Disease . 3rd ed.. 2005;
  16. American Thoracic Society . Lung function testing (selection of reference values and interpretative strategies) . Am Rev Respir Dis . 1991;144:1202–1218
  17. Freudenberg TD , Madtes DK , Curtis RJ , Cummings P , Storer BE , Hackman RC . Association between acute and chronic graft versus host disease and bronchiolitis obliterans organizing pneumonia in recipients of hematopoietics stem cell transplants . Blood . 2003;102:3822–3828
  18. Dominietto A , van Lint MT , Gualandi F , et al.   Is timing of anti-thymocyte globulin (ATG)—pre and post hematopoietic stem cell transplants (HSCT)—relevant for graft-vs-host disease (GVHD)? . [abstract] Blood . 2003;102:851
  19. Van Esser JWJ , van der Holt B , Meijer E , et al.   Epstein-Barr virus (EBV) reactivation is a frequent event after allogeneic stem cell transplantation (SCT) and quantitatively predicts EBV-lymphoproliferative disease following T-cell-depleted SCT . Blood . 2001;98:972–978
  20. Champlin RE , Passweg JR , Zhang MJ , et al.   T-cell depletion of bone marrow transplants for leukemia from donors other than HLA-identical siblings (advantage of T-cell antibodies with narrow specificities) . Blood . 2000;95:3996–4003

PII: S1083-8791(05)01416-3

doi: 10.1016/j.bbmt.2005.12.034

Biology of Blood and Marrow Transplantation
Volume 12, Issue 5 , Pages 560-565 , May 2006

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