Biology of Blood and Marrow Transplantation
Volume 12, Issue 5 , Pages 566-572 , May 2006

Altered Functional Status of the Hypothalamic Dopaminergic Tone in Patients with Chronic Graft-versus-Host Disease after Allogeneic Hematopoietic Stem Cell Transplantation: A Pilot Study

  • Adalberto Parra

      Affiliations

    • Department of Endocrinology, Instituto Nacional de Perinatología, Mexico City, Mexico
    • ,
  • Jorge Ramírez-Peredo

      Affiliations

    • Department of Rheumatology, Instituto Nacional de Perinatología, Mexico City, Mexico
    • ,
  • Rocío Hidalgo

      Affiliations

    • Department of Endocrinology, Instituto Nacional de Perinatología, Mexico City, Mexico
    • ,
  • Amelia Morales-Toquero

      Affiliations

    • Laboratorios Clínicos de Puebla, Mexico City, Mexico
    • Centro de Hematología y Medicina Interna de Puebla, Mexico City, Mexico
    • ,
  • Gabriela Velásquez-Ramírez

      Affiliations

    • Laboratorios Clínicos de Puebla, Mexico City, Mexico
    • ,
  • Alejandro Ruiz-Argüelles

      Affiliations

    • Laboratorios Clínicos de Puebla, Mexico City, Mexico
    • ,
  • Guillermo J. Ruiz-Argüelles

      Affiliations

    • Laboratorios Clínicos de Puebla, Mexico City, Mexico
    • Centro de Hematología y Medicina Interna de Puebla, Mexico City, Mexico
    • Corresponding Author InformationCorrespondence and reprint requests: Guillermo J. Ruiz-Argüelles, MD, FACP, FRCP (Glasg), Centro de Hematología y Medicina Interna de Puebla, 8B Sur 3710, 72530 Puebla, PUE, Mexico

Received 17 October 2005 ,Accepted 16 December 2005.

References 

  1. Thomas ED . Hematopoietic stem cell transplantation . Sci Am . 1995;272:38–47
  2. Ruiz-Argüelles GJ , Gómez-Almaguer D . Braking dogmata to help patients (non-myeloablative hamatopoietic stem cell transplantation) . Expert Opin Biol Ther . 2004;4:1693–1699
  3. Lunn RA , Sumar N , Bansal AS , Treleaven J . Cytokine profiles in stem cell transplantation (possible use as a predictor of graft-versus-host disease) . Hematology . 2005;10:107–114
  4. Reddy P . Pathophysiology of acute graft-versus-host disease . Hematol Oncol . 2003;21:149–161
  5. Krenger W , Ferrara JL . Graft-versus-host disease and the Th1/Th2 paradigm . Immunol Res . 1996;15:50–73
  6. Hinterberger-Fischer M , Kier P , Spona J , et al.   Prolactin (a possible mediator of graft-versus-host disease following allogeneic bone marrow transplantation in humans) . Bone Marrow Transplant . 1994;14:403–406
  7. Hinterberger-Fischer M , Ogris E , Kier P , et al.   Elevation of plasma prolactin in patients undergoing autologous blood stem-cell transplantation for breast cancer (is its modulation a step forward posttransplant immunotherapy?) . Am J Clin Oncol . 2000;23:325–329
  8. Ben-Jonathan N , Mershon JL , Allen DL , Steinmetz RW . Extrapituitary prolactin (distribution, regulation, functions, and clinical aspects) . Endocr Rev . 1996;17:639–669
  9. Matera L . Action of pituitary and lymphocyte prolactin . Neuroimmunomodulation . 1997;4:171–180
  10. Matera L , Mori M . Cooperation of pituitary hormone prolactin with interleukin-2 and interleukin-12 on production of interferon-gamma by natural killer and T cells . Ann N Y Acad Sci . 2000;917:505–513
  11. Reber PM . Prolactin and immunomodulation . Am J Med . 1993;95:637–644
  12. Berczi I , Nagy E , Kovacks K , Horvath E . Regulation of humoral immunity in rats by pituitary hormones . Acta Endocrinol . 1981;98:506–513
  13. Nagy E , Berczi I , Friesen HG . Regulation of immunity in rats by lactogenic and growth hormones . Acta Endocrinol . 1983;102:351–357
  14. Neidhart M . Elevated serum prolactin or elevated prolactin/cortisone ratio are associated with autoimmune processes in systemic lupus erythematosus and other connective tissue diseases . J Rheumatol . 1996;23:476–481
  15. Jara LJ , Gómez-Sánchez C , Silveira LH , Martínez-Osuna P , Vasey FB , Espinosa LR . Hyperprolactinemia in systemic lupus erythematosus (association with disease activity) . Am J Med Sci . 1992;202:222–226
  16. Matera L . Endocrine, paracrine and autocrine actions of prolactin on immune cells . Life Sci . 1996;59:599–614
  17. Clevenger CV , Freier DO , Kline JB . Prolactin receptor signal transduction in cells of the immune system . J Endocrinol . 1998;157:187–197
  18. Matera L , Mori M , Geuna M , Buttiglieri S , Palestro G . Prolactin in autoimmunity and antitumor defence . J Neuroimmunol . 2000;109:47–55
  19. Welniak LA , Richards SM , Murphy WJ . Effects of prolactin on hematopoiesis . Lupus . 2001;10:700–705
  20. Richards SM , Murphy WJ . Use of human prolactin as a therapeutic protein to potentiate immunohematopoietic function . J Neuroimmunol . 2000;109:56–62
  21. Sun R , Gault RA , Welniak LA , Tian ZG , Richards S , Murphy WJ . Immunologic and hematopoietic effects of recombinant human prolactin after syngeneic bone marrow transplantation in mice . Biol Blood Marrow Transplant . 2003;9:426–434
  22. Ben-Jonathan N . Dopamine (a prolactin-inhibiting hormone) . Endocr Rev . 1985;6:564–589
  23. Quigley ME , Judd SJ , Gilliland GB , Yen SSC . Effects of a dopamine antagonist on the release of gonadotropin and prolactin in normal women and in women with hyperprolactinemic anovulation . J Clin Endocrinol Metab . 1979;48:718–720
  24. Parra A , Ramírez-Peredo J , Larrea F , et al.   Decreased endogenous dopaminergic tone and increased basal bioactive prolactin in men with human immunodeficiency virus infection . Clin Endocrinol (Oxf) . 2001;54:731–738
  25. Birnbacher R , Scheibenreiter S , Blau N , Bieglmayer C , Frisch H , Waldhauser F . Hyperprolactinemia, a tool in treatment control of tetrahydrobiopterin deficiency (endocrine studies in an affected girl) . Pediatr Res . 1998;43:472–477
  26. Ben-Jonathan N , Mershon JL , Allen DL , Steinmetz RW . Extrapituitary prolactin (distribution, regulation, functions, and clinical aspects) . Endocr Rev . 1996;17:639–669
  27. Nagy E , Berczi I . Hypophysectomized rats depend on residual prolactin for survival . Endocrinology . 1991;128:2776–2784
  28. Yen SSC . Prolactin in human reproduction . In:  Yen SSC ,  Jaffe RB editor. Reproductive Endocrinology . 3rd ed.. Philadelphia: Saunders; 1991;p. 357–388
  29. Kessinger A , Armitage JO , Landmark JD , Smith DM , Weisenburger DD . Autologous peripheral hematopoietic stem cell transplantation restores hemopoietic function following marrow ablative therapy . Blood . 1998;71:723–727
  30. Ruiz-Argüelles A . Flow cytometry in the clinical laboratory. Principles, applications and problems . Ann Biol Clin . 1992;50:735–743
  31. Ruiz-Argüelles A , Orfao A . Caracterización y evaluación de células totipotenciales en sangre periférica y médula ósea . In:  Ruiz-Argüelles GJ ,  San-Miguel JF editor. Actualización en Leucemias . Mexico City: Editorial Médica Panamericana; 1996;p. 79–82
  32. Ruiz-Argüelles GJ , Gómez-Almaguer D , Ruiz-Argüelles A , González-Llano O , Cantú OG , Jaime-Pérez JC . Results of an outpatient-based stem cell allotransplant program using non-myeloablative conditioning regimens . Am J Hematol . 2001;66:241–244
  33. Ruiz-Argüelles GJ , Gómez-Almaguer D , López-Martínez B , Cantú-Rodríguez OG , Jaime-Pérez JC , González-Llano O . Results of an allogeneic non-myeloablative stem cell transplantation program in patients with chronic myelogenous leukemia . Haematologica . 2002;87:894–896
  34. Ruiz-Argüelles GJ . Allogeneic stem cell transplantation using non-myeloablative conditioning regimens (results of the Mexican approach) . Int J Hematol . 2002;76(suppl 1):376–379
  35. Gómez-Almaguer D , Ruiz-Argüelles GJ , Tarín-Arzaga LC , et al.   Reduced-intensity stem cell transplantation in children and adolescents (the Mexican experience) . Biol Blood Marrow Transplant . 2003;9:157–161
  36. Giralt S , Estey E , Albitar M , et al.   Engraftment of allogeneic hematopoietic progenitor cells with purine analog-containing chemotherapy (harnessing graft-versus-leukemia without myeloablative therapy) . Blood . 1997;89:4531–4536
  37. Slavin S , Nagler A , Naparstek E , et al.   Nonmyeloablative stem cell transplantation and cell therapy as an alternative to conventional bone marrow transplantation with lethal cytoreduction for the treatment of malignant and nonmalignant hematological diseases . Blood . 1998;91:756–763
  38. Kansu E . The pathophysiology of chronic graft-versus-host disease . Int J Hematol . 2004;79:209–215
  39. Pinkel D , Straume T , Gray JW . Cytogenetic analysis using quantitative, high-sensitivity, fluorescence hybridization . Proc Natl Acad Sci U S A . 1996;83:2934–2938
  40. Ruiz-Argüelles GJ , López-Martínez B , Santellán-Olea MR , et al.   Follow up of hemopoietic chimerism in individuals given allogeneic hemopoietic stem cell allografts using an immunosuppressive, non-myeloablative conditioning regimen (a prospective study in a single institution) . Leuk Lymphoma . 2002;43:1509–1511
  41. Yam P , Petz L , Knowlton R , et al.   Use of DNA restriction fragment length polymorphisms to document marrow engraftment and mixed hematopoietic chimerism following bone marrow transplantation . Transplantation . 1987;43:399–407
  42. Parra A , Barrón J , Sinibaldi J , Coria I , Espinosa de los Monteros A . Differences in the metoclopramide-induced prolactin release related to age at first full-term pregnancy or nulliparity . Hum Reprod . 1997;12:214–219
  43. Tai MM . A mathematical model for the determination of total area under glucose tolerance and other metabolic curves . Diabetes Care . 1994;17:152–154
  44. Takemoto M , Morishita M , Higuchi K , Yoshida J , Aono T . Effects of body weight on responses of serum prolactin to metoclopramide and thyrotrophin releasing hormone in secondary amenorrheic women . Hum Reprod . 1994;9:800–805
  45. World Health Organization . Obesity: Preventing and Managing the Global Epidemic. WHO Obesity Technical Report Series 894 . Geneva: World Health Organization; 2000;
  46. Espinosa de los Monteros A , Cornejo J , Parra A . Differential prolactin response to oral metoclopramide in nulliparous versus parous women throughout the menstrual cycle . Fertil Steril . 1991;55:885–889
  47. Méndez I , Alcocer-Varela J , Parra A , et al.   Neuroendocrine dopaminergic regulation of prolactin release in systemic lupus erythematosus (a possible role of lymphocyte-derived prolactin) . Lupus . 2004;13:45–53
  48. McMurray R , Keisler D , Kanuckel K , Izui S , Walker SE . Prolactin influences autoimmune disease activity in the female B/W mouse . J Immunol . 1991;147:3780–3787
  49. Berczi I , Baragar FD , Chalmers IM , Keystone EC , Nagy E , Warrington RJ . Hormones in self tolerance and autoimmunity (a role in the pathogenesis of rheumatoid arthritis?) . Autoimmunity . 1993;16:45–46
  50. Walker SE . Prolactin, a pituitary hormone that modifies immune responses . Lupus . 1998;7:371–375

PII: S1083-8791(05)01418-7

doi: 10.1016/j.bbmt.2005.12.035

Biology of Blood and Marrow Transplantation
Volume 12, Issue 5 , Pages 566-572 , May 2006

Article Tools

* Image Usage & Resolution