Biology of Blood and Marrow Transplantation
Volume 12, Issue 5 , Pages 506-510 , May 2006

Iron Overload Manifesting as Apparent Exacerbation of Hepatic Graft-versus-Host Disease after Allogeneic Hematopoietic Stem Cell Transplantation

  • Rammurti T. Kamble

      Affiliations

    • Oklahoma University Health Sciences Center, Oklahoma City, Oklahama
    • Corresponding Author InformationCorrespondence and reprint requests: Rammurti T. Kamble, MD, Oklahoma University Health Sciences Center, 920 S.L. Young Blvd., WP-2080, Oklahoma City, OK 73190
  • ,
  • George B. Selby

      Affiliations

    • Oklahoma University Health Sciences Center, Oklahoma City, Oklahama
  • ,
  • Martha Mims

      Affiliations

    • Baylor College of Medicine, Houston, Texas
  • ,
  • Mohamed A. Kharfan-Dabaja

      Affiliations

    • Oklahoma University Health Sciences Center, Oklahoma City, Oklahama
  • ,
  • Howard Ozer

      Affiliations

    • Oklahoma University Health Sciences Center, Oklahoma City, Oklahama
  • ,
  • James N. George

      Affiliations

    • Oklahoma University Health Sciences Center, Oklahoma City, Oklahama

Received 10 November 2005 ,Accepted 5 January 2006.

References 

  1. Marcus RE , Huehns ER . Transfusional iron overload . Clin Lab Hematol . 1985;7:195–212
  2. McKay PJ , Murphy JA , Cameron S , et al.   Iron overload and liver dysfunction after allogeneic or autologous bone marrow transplantation . Bone Marrow Transplant . 1996;17:63–66
  3. Lichtman SM , Attivissimo L , Goldman IS , Schuster MW , Buchbinder A . Secondary hemochromatosis as a long-term complications of the treatment of hematologic malignancies . Am J Hematol . 1999;61:262–264
  4. Tomas JF , Pinilla I , Garcia-Buey ML , et al.   Long term liver dysfunction after allogeneic bone marrow transplantation (clinical features and course in 61 patients) . Bone Marrow Transplant . 2000;26:649–655
  5. Halonen P , Mattila J , Suominen P , Ruuska T , Salo MK , Makipernaa A . Iron overload in children who are treated for acute lymphoblastic leukemia estimated by liver siderosis and serum iron parameters . Pediatrics . 2003;111:91–96
  6. Barton JC , Bertoli LF . Transfusion iron overload in adults with acute leukemia (manifestations and therapy) . Am J Med. Science . 2000;319:73–78
  7. Strasser SI , Kowdley KV , Sale GE , McDonald GB . Iron overload in bone marrow transplant recipients . Bone Marrow Transplant . 1998;22:167–173
  8. Butt NM , Clark RE . Autografting as a risk factor for persisting iron overload in long terms survivors of acute leukemia . Bone Marrow Transplant . 2003;32:909–913
  9. Franchini M , Gandini G , Veneri D , et al.   Efficacy and safety of phlebotomy to reduce transfusional iron overload in adult, long-term survivors of acute leukemia . Transfusion . 2004;44:833–837
  10. Mahindra P , Hood IM , Bass G , Patterson P , Marcus RE . Severe hemosiderosis post allogeneic bone marrow transplantation . Hematol Oncol . 1996;14:33–35
  11. Schafer AI , Cheron RG , Dluhy R , et al.   Clinical consequences of acquired transfusional iron overload in adults . N Engl J Med . 1981;304:319–324
  12. Jensen PD , Jensen FT , Christensen T , Nielsen JL , Ellegaard J . Relationship between hepatocellular injury and transfusion iron overload prior to and during iron chelation with desferrioxamine (a study in adult patients with acquired anemia) . Blood . 2003;101:91–96
  13. Porter JB . Practical management of iron overload . Br J Hematol . 2001;115:239–252
  14. Alustiza JM , Artetxe J , Castiella C , et al.   MR quantification of hepatic iron concentration . Radiology . 2004;230:479–484
  15. Atkinson K , Horowitz MM , Gale RP , Lee MB , Rimm AA , Bortin MM . Consensus among bone marrow transplanters for diagnosis, grading and treatment of chronic graft-versus-host disease . Bone Marrow Transplant . 1989;4:247–254
  16. Beutler E , Hoffbrand AV , Cook JD . Hematology iron deficiency and overload . Hematology (Am Soc Hematol Educ Program) . 2003;40–61
  17. Muretto P , Del Fiasco S , Angelucci E , De Rosa F , Lucarelli G . Bone marrow transplantation in thalassemia (modifications of hepatic iron overload and associated lesions after long-term engrafting) . Liver . 1994;14:14–24
  18. Bonkovsky HL , Banner BF , Rothman AL . Iron and chronic viral hepatitis . Hepatology . 1997;25:759–768
  19. Altes A , Remacha AF , Sarda P , et al.   Frequent severe liver iron overload after stem cell transplantation and its possible association with invasive aspergillosis . Bone Marrow Transplant . 2004;34:505–509
  20. Worwood M . Serum ferritin . Clin Sci . 1986;70:215–220
  21. Chapman RW , Hussain MA , Gorman A , et al.   Effect of ascorbic acid deficiency on serum ferritin concentration in patients with beta-thalassemia major and iron overload . J Clin Pathol . 1982;35:487–491
  22. Lucarelli G , Angelucci E , Giardini C , et al.   Fate of iron stores in thalassaemia after bone marrow transplant . Lancet . 1993;342:1388–1391
  23. Ganz T . Hepcidin, a key regulator of iron metabolism and mediator of anemia of inflammation . Blood . 2003;102:783–788
  24. Detivaud L , Nemeth E , Boudjema K , et al.   Hepcidin levels in humans are correlated with hepatic iron stores, hemoglobin levels, and hepatic function . Blood . 2005;106:746–748
  25. St Pierre TG , Clark PR , Chua-anusorn W , et al.   Noninvasive measurement and imaging of liver iron concentrations using proton magnetic resonance . Blood . 2005;105:855–861
  26. Galanello R , Piga A , Alberti D , Rouan MC , Bigler H , Sechaud R . Safety, tolerability, and pharmacokinetics of ICL670, a new orally active iron-chelating agent in patients with transfusion-dependent iron overload due to beta-thalassemia . J Clin Pharmacol . 2003;43:565–572
  27. Cohen AR , Galanello R , Piga A , De Sanctis V , Tricta F . Safety and effectiveness of long-term therapy with the oral iron chelator deferiprone . Blood . 2003;102:1583–1587

PII: S1083-8791(06)00044-9

doi: 10.1016/j.bbmt.2006.01.004

Biology of Blood and Marrow Transplantation
Volume 12, Issue 5 , Pages 506-510 , May 2006