Biology of Blood and Marrow Transplantation
Volume 12, Issue 5 , Pages 511-517 , May 2006

Evidence of Donor-Derived Hematologic Malignancies after Hematopoietic Stem Cell Transplantation

  • Olga Sala-Torra

      Affiliations

    • Division of Clinical Research, Program in Genetics and Genomics, Fred Hutchinson Cancer Research Center, Seattle, Washington
    • Corresponding Author InformationCorrespondence and reprint requests: Olga Sala-Torra, MD, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave. N., D4-100, Seattle, WA 98109
    • ,
  • Colleen Hanna

      Affiliations

    • Division of Clinical Research, Program in Genetics and Genomics, Fred Hutchinson Cancer Research Center, Seattle, Washington
    • ,
  • Michael R. Loken

      Affiliations

    • HematoLogics, Inc., Seattle, Washington
    • ,
  • Mary E.D. Flowers

      Affiliations

    • Division of Clinical Research, Program in Genetics and Genomics, Fred Hutchinson Cancer Research Center, Seattle, Washington
    • ,
  • Michael Maris

      Affiliations

    • Division of Clinical Research, Program in Genetics and Genomics, Fred Hutchinson Cancer Research Center, Seattle, Washington
    • ,
  • Paula A. Ladne

      Affiliations

    • Division of Clinical Research, Program in Genetics and Genomics, Fred Hutchinson Cancer Research Center, Seattle, Washington
    • ,
  • James R. Mason

      Affiliations

    • Blood and Marrow Transplantation Program, Scripps Clinic Torrey Pines, La Jolla, California
    • ,
  • David Senitzer

      Affiliations

    • Division of Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical Center, Duarte, California
    • ,
  • Roberto Rodriguez

      Affiliations

    • Division of Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical Center, Duarte, California
    • ,
  • Stephen J. Forman

      Affiliations

    • Division of Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical Center, Duarte, California
    • ,
  • H. Joachim Deeg

      Affiliations

    • Division of Clinical Research, Program in Genetics and Genomics, Fred Hutchinson Cancer Research Center, Seattle, Washington
    • ,
  • Jerald P. Radich

      Affiliations

    • Division of Clinical Research, Program in Genetics and Genomics, Fred Hutchinson Cancer Research Center, Seattle, Washington

Received 8 June 2004 ,Accepted 12 January 2006.

References 

  1. Myron Kauffman H , McBride MA , Cherikh WS , et al.   Transplant tumor registry (donor related malignancies) . Transplantation . 2002;74:358–362
  2. Boyd CN , Ramberg RC , Thomas ED . The incidence of recurrence of leukemia in donor cells after allogeneic bone marrow transplantation . Leuk Res . 1982;6:833–837
  3. Maloney DG , Molina AJ , Sahebi F , et al.   Allografting with nonmyeloablative conditioning following cytoreductive autografts for the treatment of patients with multiple myeloma . Blood . 2003;102:3447–3454
  4. Maris MB , Niederwieser D , Sandmaier BM , et al.   HLA-matched unrelated donor hematopoietic cell transplantation after nonmyeloablative conditioning for patients with hematologic malignancies . Blood . 2003;102:2021–2030
  5. Smith JL , Heerema NA , Provisor AJ . Leukaemic transformation of engrafted bone marrow cells . Br J Haematol . 1985;60:415–422
  6. Witherspoon RP , Schubach W , Neiman P , et al.   Donor cell leukemia developing six years after marrow grafting for acute leukemia . Blood . 1985;65:1172–1174
  7. Thomas ED , Bryant JI , Buckner CD , et al.   Leukemic transformation of engrafted human marrow . Transplant Proc . 1972;4:567–570
  8. Niederwieser DW , Appelbaum FR , Gastl G , et al.   Inadvertent transmission of a donor’s acute myeloid leukemia in bone marrow transplantation for chronic myelocytic leukemia . N Engl J Med . 1990;322:1794–1796
  9. Newburger PE , Latt SA , Pesando JM , et al.   Leukemia relapse in donor cells after allogeneic bone-marrow transplantation . N Engl J Med . 1981;304:712–714
  10. Mielcarek M , Bryant E , Loken M , et al.   Haemopoietic reconstitution by donor-derived myelodysplastic progenitor cells after haemopoietic stem cell transplantation . Br J Haematol . 1999;105:361–365
  11. Marmont A , Frassoni F , Bacigalupo A , et al.   Recurrence of Ph’-positive leukemia in donor cells after marrow transplantation for chronic granulocytic leukemia . N Engl J Med . 1984;310:903–906
  12. Goh K , Klemperer MR . In vivo leukemic transformation (cytogenetic evidence of in vivo leukemic transformation of engrafted marrow cells) . Am J Hematol . 1977;2:283–290
  13. Cooley LD , Sears DA , Udden MM , et al.   Donor cell leukemia (report of a case occurring 11 years after allogeneic bone marrow transplantation and review of the literature) . Am J Hematol . 2000;63:46–53
  14. Elfenbein GJ , Brogaonkar DS , Bias WB , et al.   Cytogenetic evidence for recurrence of acute myelogenous leukemia after allogeneic bone marrow transplantation in donor hematopoietic cells . Blood . 1978;52:627–636
  15. Fialkow PJ , Thomas ED , Bryant JI , Neiman PE . Leukaemic transformation of engrafted human marrow cells in vivo . Lancet . 1971;1:251–255
  16. Palka G , Calabrese G , Di Girolamo G , et al.   Cytogenetic survey of 31 patients treated with bone marrow transplantation for acute nonlymphocytic and acute lymphoblastic leukemias . Cancer Genet Cytogenet . 1991;51:223–233
  17. Palka G , Di Bartolomeo P , Iacone A , et al.   Cytogenetics and bone marrow transplantation . Cancer Genet Cytogenet . 1986;21:147–157
  18. Zaccaria A , Rosti G , Testoni N , et al.   Chromosome studies in patients with acute nonlymphocytic or acute lymphocytic leukemia submitted to bone marrow transplantation—results of a European cooperative study . Cancer Genet Cytogenet . 1987;26:51–58
  19. Schmitz N , Johannson W , Schmidt G , et al.   Recurrence of acute lymphoblastic leukemia in donor cells after allogeneic marrow transplantation associated with a deletion of the long arm of chromosome 6 . Blood . 1987;70:1099–1104
  20. Feig SA , Dreazen O , Simon M , et al.   B cell acute lymphoblastic leukemia (ALL) in donor cells following bone marrow transplantation for T cell ALL . Bone Marrow Transplant . 1988;3:331–337
  21. Browne PV , Lawler M , Humphries P , McCann SR . Donor-cell leukemia after bone marrow transplantation for severe aplastic anemia . N Engl J Med . 1991;325:710–713
  22. McCann SR , Lawler M , Bacigalupo A . Recurrence of Philadelphia chromosome-positive leukemia in donor cells after bone marrow transplantation for chronic granulocytic leukemia . Leuk Lymphoma . 1993;10:419–425
  23. McCann SR , Lawler M , Humphries P , et al.   Recurrence of Philadelphia chromosome-positive leukemia in donor cells after marrow transplantation for chronic granulocytic leukemia (confirmation by microsatellite studies) . Blood . 1992;79:2803–2805
  24. Cullis JO , Marks DI , Schwarer AP , et al.   Relapse into blast crisis following bone marrow transplantation for chronic phase chronic myeloid leukaemia (a report of five cases) . Br J Haematol . 1992;81:378–382
  25. Katz F , Reeves BR , Alexander S , et al.   Leukaemia arising in donor cells following allogeneic bone marrow transplantation for beta thalassaemia demonstrated by immunological, DNA and molecular cytogenetic analysis . Br J Haematol . 1993;85:326–331
  26. Mouratidou M , Sotiropoulos D , Deremitzaki K , et al.   Recurrence of acute leukemia in donor cells after bone marrow transplantation (documentation by in situ DNA hybridization) . Bone Marrow Transplant . 1993;12:77–80
  27. Cransac M , Boiron JM , Merel P , et al.   Burkitt-type acute lymphoblastic leukemia in donor cells after allogeneic bone marrow transplantation for acute nonlymphoblastic leukemia . Transplantation . 1993;56:120–123
  28. Lowsky R , Fyles G , Minden M , et al.   Detection of donor cell derived acute myelogenous leukaemia in a patient transplanted for chronic myelogenous leukaemia using fluorescence in situ hybridization . Br J Haematol . 1996;93:163–165
  29. Schubach WH , Hackman R , Neiman PE , et al.   A monoclonal immunoblastic sarcoma in donor cells bearing Epstein-Barr virus genomes following allogeneic marrow grafting for acute lymphoblastic leukemia . Blood . 1982;60:180–187
  30. Gossett TC , Gale RP , Fleischman H , et al.   Immunoblastic sarcoma in donor cells after bone-marrow transplantation . N Engl J Med . 1979;300:904–907
  31. Berg KD , Brinster NK , Huhn KM , et al.   Transmission of a T-cell lymphoma by allogeneic bone marrow transplantation . N Engl J Med . 2001;345:1458–1463
  32. Baron F , Dresse MF , Beguin Y . Transmission of chronic myeloid leukemia through peripheral-blood stem-cell transplantation . N Engl J Med . 2003;349:913–914
  33. Deeg HJ , Sanders J , Martin P , et al.   Secondary malignancies after marrow transplantation . Exp Hematol . 1984;12:660–666
  34. Hertenstein B , Hambach L , Bacigalupo A , et al.   Development of leukemia in donor cells after allogeneic stem cell transplantation—a survey of the European Group for Blood and Marrow Transplantation (EBMT) . Haematologica . 2005;90:969–975
  35. Rawstron AC , Green MJ , Kuzmicki A , et al.   Monoclonal B lymphocytes with the characteristics of “indolent” chronic lymphocytic leukemia are present in 3.5% of adults with normal blood counts . Blood . 2002;100:635–639
  36. Ghia P , Prato G , Scielzo C , et al.   Monoclonal CD5+ and CD5− B-lymphocyte expansions are frequent in the peripheral blood of the elderly . Blood . 2004;103:2337–2342
  37. Liu Y , Hernandez AM , Shibata D , Cortopassi GA . BCL2 translocation frequency rises with age in humans . Proc Natl Acad Sci U S A . 1994;91:8910–8914
  38. Ji W , Qu GZ , Ye P , et al.   Frequent detection of bcl-2/JH translocations in human blood and organ samples by a quantitative polymerase chain reaction assay . Cancer Res . 1995;55:2876–2882
  39. Niederwieser D , Gentilini C , Hegenbart U , et al.   Transmission of donor illness by stem cell transplantation (should screening be different in older donors?) . Bone Marrow Transplant . 2004;34:657–665
  40. Flowers M , Deeg HJ . Delayed complications after hematopoietic cell transplantation . In:  Blume K ,  Forman S ,  Appelbaum F editor. Thomas’ Hematopoietic Cell Transplantation . Malden, MA: Blackwell Publishing Ltd; 2004;p. 944–961

PII: S1083-8791(06)00068-1

doi: 10.1016/j.bbmt.2006.01.006

Biology of Blood and Marrow Transplantation
Volume 12, Issue 5 , Pages 511-517 , May 2006

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