Biology of Blood and Marrow Transplantation
Volume 12, Issue 5 , Pages 518-529 , May 2006

Immune Tolerance to Self-Major Histocompatability Complex Class II Antigens after Bone Marrow Transplantation: Role of Regulatory T Cells

  • Allan D. Hess

      Affiliations

    • Corresponding Author InformationCorrespondence and reprint requests: Allan D. Hess, PhD, The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University, 1650 Orleans St, Baltimore, MD 21231
  • ,
  • Christopher J. Thoburn

Received 12 August 2005 ,Accepted 12 January 2006.

References 

  1. Glazier A , Tutschka PJ , Farmer ER , et al.   GVHD in CsA treated rats after syngeneic and autologous bone marrow reconstitution . J Exp Med . 1983;158:1–12
  2. Hess AD , Thoburn CJ . Immunobiology and immunotherapeutic implications of syngeneic/autologous graft-vs-host disease . Immunol Rev . 1997;157:111–123
  3. Chen W , Thoburn C , Hess AD . Characterization of the pathogenic autoreactive T cells in cyclosporine-induced syngeneic graft-vs-host disease . J Immunol . 1998;161:7040–7046
  4. Thoburn CJ , Miura Y , Bright EC , et al.   Functional divergence of antigen-specific T-lymphocyte responses in syngeneic graft-versus-host disease . Biol Blood Marrow Transplant . 2004;10:591–603
  5. Hess AD , Thoburn CJ , Horwitz L . Promiscuous recognition of major histocompatibility complex class II determinants in cyclosporine-induced syngeneic graft-vs-host disease . Transplantation . 1998;65:785–792
  6. Teshima T , Reddy P , Liu C , et al.   Impaired negative selection causes autoimmune graft-versus-host disease . Blood . 2003;102:429–435
  7. Tivol E , Komorowkski R , Drobyski WR . Emergent autoimmunity in graft-versus-host disease . Blood . 2005;105:4885–4891
  8. Fischer AC , Beschorner WE , Hess AD . Requirements for the induction and adoptive transfer of syngeneic GVHD . J Exp Med . 1989;169:1031–1038
  9. Hequet O , Vocanson M , Saint-Mezard P , et al.   CD4+ T cells prevent skin autoimmunity during chronic autologous graft-versus-host disease . Int J Transplant . 2004;4:872–878
  10. Hess AD , Fischer AC , Horwitz L , et al.   Characterization of peripheral autoregulatory mechanisms that prevent development of cyclosporine-induced syngeneic graft-vs-host disease . J Immunol . 1994;153:400–411
  11. Wu DY , Goldschneider I . Cyclosporin-induced autologous graft-vs-host disease (a prototypical model of autoimmunity and active (dominant) tolerance coordinately expressed induced by recent thymic emigrants) . J Immunol . 1999;162:6926–6933
  12. Miura Y , Thoburn CJ , Bright EC , et al.   Association of Foxp3 gene expression with graft-versus-host disease . Blood . 2004;104:2187–2193
  13. Hess AD , Thoburn C , Chen W , et al.   The N-terminal flanking region of the invariant chain peptide augments the immunogenicity of a cryptic “self” epitope from a tumor-associated antigen . Clin Immunol . 2001;101:67–76
  14. Hess AD , Thoburn CJ , Miura Y , et al.   Functionally divergent T lymphocyte responses induced by modification of a self-peptide from a tumor-associated antigen . Clin Immunol . 2005;114:307–319
  15. Hori S , Nomura T , Sakaguchi S . Control of regulatory T cell development by the transcription factor Foxp3 . Science . 2003;299:1057–1061
  16. Khattri R , Cox T , Yasayko SA , et al.   An essential role for Scurfin in CD4+CD25+ T regulatory cells . Nat Immunol . 2003;4:337–342
  17. Shevach E . Regulatory T cells in autoimmunity . Ann Rev Immunol . 2000;18:423–449
  18. Read S , Powrie F . CD4+ regulatory T cells . Curr Opin Immunol . 2001;13:644–649
  19. Sakaguchi S . Naturally arising CD4+ regulatory T cells for immunologic self-tolerance and negative control of immune responses . Ann Rev Immunol . 2004;22:531–562
  20. Kronenberg M , Rudensky A . Regulation of immunity by self-reactive T cells . Nature . 2005;435:598–604
  21. Ben-Nunn AH , Wekerle H , Cohen H . Vaccination against autoimmune encephalomyelitis with a T lymphocyte line reactive against myelin basic protein . Nature . 1981;292:60–64
  22. Acha-Orbea H , Mitchell TJ , Timmerman L . Limited heterogeneity of the T cell receptors from lymphocytes mediating autoimmune encephalomyelitis allows specific immune intervention . Cell . 1988;54:263–271
  23. Gutierrez-Ramos JC , Andrew JL , Moreno Alboran I . Insights into autoimmunity; from classical models to current perspectives . Immunol Rev . 1990;118:73–84
  24. Piccirillo CA , Shevach EM . Naturally-occurring CD4+CD25+ immunoregulatory T cells (central players in the arena of peripheral tolerance) . Semin Immunol . 2004;16:81–88
  25. Hess AD , Thoburn CJ , Chen W , et al.   Complexity of effector mechanisms in syngeneic graft-vs-host disease . Biol Blood Marrow Transplant . 2000;6:13–24
  26. Fontenot JD , Rudensky AY . A well adapted regulatory contrivance (regulatory T cell development and the forkhead transcription factor Foxp3) . Nat Immunol . 2005;6:331–337
  27. Fischer AC , Hess AD . Age related factors in cyclosporine-induced syngeneic graft-versus-host disease (regulatory role of marrow-derived lymphocytes) . J Exp Med . 1990;172:85–94
  28. Beschorner WE , Ren H , Phillips J , et al.   Recovery of thymic microenvironment after cyclosporine prevents syngeneic graft-vs-host disease . Transplantation . 1991;52:668–674
  29. Wood KJ , Sakaguchi S . Regulatory T cells in transplantation tolerance . Nat Rev . 2003;3:199–210
  30. Graca L , Chen T-C , Le Moine A , et al.   Dominant tolerance (activation thresholds for peripheral generation of regulatory T cells) . Trends Immunol . 2005;26:130–135
  31. Hsueh C-S , Liang Y , Tyznik AJ , et al.   Recognition of the peripheral self by naturally arising CD25+CD4+ T cell receptors . Immunity . 2004;21:267–277
  32. Rohn TA , Boes M , Wolters D , et al.   Upregulation of the CLIP self-peptide on mature dendritic cells antagonizes T helper type 1 polarization . Nat Immunol . 2004;5:909–918
  33. Kasai M , Kropshofer H , Vogt A , et al.   CLIP-derived self-peptides bound to MHC class II molecules of medullary thymic epithelial cells differ from those of cortical thymic epithelial cells in their diversity, length and C-terminal processing . Eur J Immunol . 2000;30:3542–3551
  34. Tutschka PJ , Ki P , Beschorner WE , et al.   Suppressor cells in transplantation tolerance, II (maturation of suppressor cells in the bone marrow chimera) . Transplantation . 1985;32:321–329
  35. Kupiec-Weglinski JW , Filho Strom TB , Tilney NL . Sparing of suppressor cells; a critical action of cyclosporine . Transplantation . 1983;38:97–104
  36. Hess AD . Chronic graft-versus-host disease (a breakdown of self-tolerance?) . Blood . 2005;105:4548–4549

PII: S1083-8791(06)00069-3

doi: 10.1016/j.bbmt.2006.01.007

Biology of Blood and Marrow Transplantation
Volume 12, Issue 5 , Pages 518-529 , May 2006