Biology of Blood and Marrow Transplantation
Volume 12, Issue 3 , Pages 252-266 , March 2006

Measuring Therapeutic Response in Chronic Graft-versus-Host Disease: National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: IV. Response Criteria Working Group Report

  • Steven Z. Pavletic

      Affiliations

    • National Cancer Institute, National Institutes of Health, Bethesda, Maryland
    • Corresponding Author InformationCorrespondence and reprint requests: Steven Z. Pavletic, MD, Graft-versus-Host and Autoimmunity Unit, Experimental Transplantation and Immunology Branch, National Cancer Institute, 9000 Rockville Pike, Bethesda, MD 20892-1203
    • ,
  • Paul Martin

      Affiliations

    • Fred Hutchinson Cancer Research Center, University of Washington School of Medicine, Seattle, Washington
    • ,
  • Stephanie J. Lee

      Affiliations

    • Dana-Farber Cancer Institute, Boston, Massachusetts
    • ,
  • Sandra Mitchell

      Affiliations

    • National Cancer Institute, National Institutes of Health, Bethesda, Maryland
    • ,
  • David Jacobsohn

      Affiliations

    • Children’s Memorial Hospital, Northwestern University School of Medicine, Chicago, Illinois
    • ,
  • Edward W. Cowen

      Affiliations

    • National Cancer Institute, National Institutes of Health, Bethesda, Maryland
    • ,
  • Maria L. Turner

      Affiliations

    • National Cancer Institute, National Institutes of Health, Bethesda, Maryland
    • ,
  • Gorgun Akpek

      Affiliations

    • University of Maryland School of Medicine, Baltimore, Maryland
    • ,
  • Andrew Gilman

      Affiliations

    • University of North Carolina School of Medicine, Chapel Hill, North Carolina
    • ,
  • George McDonald

      Affiliations

    • Fred Hutchinson Cancer Research Center, University of Washington School of Medicine, Seattle, Washington
    • ,
  • Mark Schubert

      Affiliations

    • Fred Hutchinson Cancer Research Center, University of Washington School of Medicine, Seattle, Washington
    • ,
  • Ann Berger

      Affiliations

    • Warren Grant Magnuson Clinical Center, National Institutes of Health, Bethesda, Maryland
    • ,
  • Peter Bross

      Affiliations

    • US Food and Drug Administration, Rockville, Maryland
    • ,
  • Jason W. Chien

      Affiliations

    • Fred Hutchinson Cancer Research Center, University of Washington School of Medicine, Seattle, Washington
    • ,
  • Daniel Couriel

      Affiliations

    • University of Texas M.D. Anderson Cancer Center, Houston, Texas
    • ,
  • J.P. Dunn

      Affiliations

    • Johns Hopkins University School of Medicine, Baltimore, Maryland
    • ,
  • Jane Fall-Dickson

      Affiliations

    • National Institute of Nursing Research, National Institutes of Health, Bethesda, Maryland
    • ,
  • Ann Farrell

      Affiliations

    • US Food and Drug Administration, Rockville, Maryland
    • ,
  • Mary E.D. Flowers

      Affiliations

    • Fred Hutchinson Cancer Research Center, University of Washington School of Medicine, Seattle, Washington
    • ,
  • Hildegard Greinix

      Affiliations

    • Medical University of Vienna, Vienna, Austria
    • ,
  • Steven Hirschfeld

      Affiliations

    • US Food and Drug Administration, Rockville, Maryland
    • ,
  • Lynn Gerber

      Affiliations

    • Warren Grant Magnuson Clinical Center, National Institutes of Health, Bethesda, Maryland
    • ,
  • Stella Kim

      Affiliations

    • University of Texas M.D. Anderson Cancer Center, Houston, Texas
    • ,
  • Robert Knobler

      Affiliations

    • Medical University of Vienna, Vienna, Austria
    • ,
  • Peter A. Lachenbruch

      Affiliations

    • US Food and Drug Administration, Rockville, Maryland
    • ,
  • Frederick W. Miller

      Affiliations

    • National Institute of Environmental Health Sciences, National Institutes of Health, Bethesda, Maryland
    • ,
  • Barbara Mittleman

      Affiliations

    • National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, Maryland
    • ,
  • Esperanza Papadopoulos

      Affiliations

    • Memorial Sloan-Kettering Cancer Center, New York, New York
    • ,
  • Susan K. Parsons

      Affiliations

    • Tufts-New England Medical Center, Boston, Massachusetts
    • ,
  • Donna Przepiorka

      Affiliations

    • University of Tennessee, Memphis, Tennessee
    • ,
  • Michael Robinson

      Affiliations

    • National Eye Institute; National Institutes of Health; Bethesda, Maryland
    • ,
  • Michael Ward

      Affiliations

    • National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, Maryland
    • ,
  • Bryce Reeve

      Affiliations

    • National Cancer Institute, National Institutes of Health, Bethesda, Maryland
    • ,
  • Lisa G. Rider

      Affiliations

    • National Institute of Environmental Health Sciences, National Institutes of Health, Bethesda, Maryland
    • ,
  • Howard Shulman

      Affiliations

    • Fred Hutchinson Cancer Research Center, University of Washington School of Medicine, Seattle, Washington
    • ,
  • Kirk R. Schultz

      Affiliations

    • University of British Columbia, British Columbia Children’s Hospital, Vancouver, British Columbia, Canada
    • ,
  • Daniel Weisdorf

      Affiliations

    • University of Minnesota, Minneapolis, Minnesota
    • ,
  • Georgia B. Vogelsang

      Affiliations

    • Johns Hopkins University School of Medicine, Baltimore, Maryland

Received 17 January 2006 ,Accepted 18 January 2006.

  • Image Result

    Skin manifestations assessed for response in chronic GVHD. A, Erythematous papular rash. B, Erythematous rash with papules and small scaly plaques. C, Dermal sclerosis. Skin is thickened, with decreas

    Skin manifestations assessed for response in chronic GVHD. A, Erythematous papular rash. B, Erythematous rash with papules and small scaly plaques. C, Dermal sclerosis. Skin is thickened, with decreased mobility to pinching but without adherence to underlying tissues. D, Subcutaneous sclerosis. Skin is hidebound, fixed to underlying tissues and cannot be pinched. Ulcers are present.

  • Image Result
    Oral manifestations assessed for response in chronic GVHD. A, Moderate erythema of vermilion lip. Labial mucosa shows severe erythema. B, Area of sheetlike lichenoid hyperkeratosis is present inside c

    Oral manifestations assessed for response in chronic GVHD. A, Moderate erythema of vermilion lip. Labial mucosa shows severe erythema. B, Area of sheetlike lichenoid hyperkeratosis is present inside commissure. C, Ulcer with pseudomembranous fibrin exudates surrounded by severe erythema. D, Numerous vesicle-like mucoceles are seen at center of the palate, with patches of lichenoid hyperkeratosis and moderate erythematous changes.

PII: S1083-8791(06)00070-X

doi: 10.1016/j.bbmt.2006.01.008

Biology of Blood and Marrow Transplantation
Volume 12, Issue 3 , Pages 252-266 , March 2006

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