Biology of Blood and Marrow Transplantation
Volume 12, Issue 4 , Pages 375-396 , April 2006

Ancillary Therapy and Supportive Care of Chronic Graft-versus-Host Disease: National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: V. Ancillary Therapy and Supportive Care Working Group Report

  • Daniel Couriel

      Affiliations

    • University of Texas MD Anderson Cancer Center, Houston, Texas
    • Corresponding Author InformationCorrespondence and reprint requests: Daniel Couriel, MD, Department of Blood and Marrow Transplantation, The University of Texas MD Anderson Cancer Center, Houston, TX 77030
  • ,
  • Paul A. Carpenter

      Affiliations

    • Fred Hutchinson Cancer Research Center, University of Washington School of Medicine, Seattle, Washington
  • ,
  • Corey Cutler

      Affiliations

    • Dana-Farber Cancer Institute, Boston, Massachusetts
  • ,
  • Javier Bolaños-Meade

      Affiliations

    • Johns Hopkins University School of Medicine, Baltimore, Maryland
  • ,
  • Nathaniel S. Treister

      Affiliations

    • Brigham and Women’s Hospital, Boston, Massachusetts
  • ,
  • Juan Gea-Banacloche

      Affiliations

    • Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland
  • ,
  • Paul Shaughnessy

      Affiliations

    • Texas Transplant Institute, San Antonio; Texas
  • ,
  • Sharon Hymes

      Affiliations

    • University of Texas MD Anderson Cancer Center, Houston, Texas
  • ,
  • Stella Kim

      Affiliations

    • University of Texas MD Anderson Cancer Center, Houston, Texas
  • ,
  • Alan S. Wayne

      Affiliations

    • Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland
  • ,
  • Jason W. Chien

      Affiliations

    • Fred Hutchinson Cancer Research Center, University of Washington School of Medicine, Seattle, Washington
  • ,
  • Joyce Neumann

      Affiliations

    • University of Texas MD Anderson Cancer Center, Houston, Texas
  • ,
  • Sandra Mitchell

      Affiliations

    • Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland
  • ,
  • Karen Syrjala

      Affiliations

    • Fred Hutchinson Cancer Research Center, University of Washington School of Medicine, Seattle, Washington
  • ,
  • Carina K. Moravec

      Affiliations

    • Fred Hutchinson Cancer Research Center, University of Washington School of Medicine, Seattle, Washington
  • ,
  • Linda Abramovitz

      Affiliations

    • University of California, San Francisco, California
  • ,
  • Jerry Liebermann

      Affiliations

    • Patient advocate, Fred Hutchinson Cancer Research Center, Seattle, Washington
  • ,
  • Ann Berger

      Affiliations

    • Warren Grant Magnuson Clinical Center, National Institutes of Health, Bethesda, Maryland
  • ,
  • Lynn Gerber

      Affiliations

    • Warren Grant Magnuson Clinical Center, National Institutes of Health, Bethesda, Maryland
  • ,
  • Mary Schubert

      Affiliations

    • Fred Hutchinson Cancer Research Center, University of Washington School of Medicine, Seattle, Washington
  • ,
  • Alexandra H. Filipovich

      Affiliations

    • Cincinnati Children’s Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio
  • ,
  • Daniel Weisdorf

      Affiliations

    • University of Minnesota, Minneapolis, Minnesota
  • ,
  • Mark M. Schubert

      Affiliations

    • Fred Hutchinson Cancer Research Center, University of Washington School of Medicine, Seattle, Washington
  • ,
  • Howard Shulman

      Affiliations

    • Fred Hutchinson Cancer Research Center, University of Washington School of Medicine, Seattle, Washington
  • ,
  • Kirk Schultz

      Affiliations

    • University of British Columbia, British Columbia Children’s Hospital, Vancouver, British Columbia, Canada
  • ,
  • Barbara Mittelman

      Affiliations

    • National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland
  • ,
  • Steven Pavletic

      Affiliations

    • Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland
  • ,
  • Georgia B. Vogelsang

      Affiliations

    • Johns Hopkins University School of Medicine, Baltimore, Maryland
  • ,
  • Paul J. Martin

      Affiliations

    • Fred Hutchinson Cancer Research Center, University of Washington School of Medicine, Seattle, Washington
  • ,
  • Stephanie J. Lee

      Affiliations

    • Fred Hutchinson Cancer Research Center, University of Washington School of Medicine, Seattle, Washington
  • ,
  • Mary E.D. Flowers

      Affiliations

    • Fred Hutchinson Cancer Research Center, University of Washington School of Medicine, Seattle, Washington

Received 7 February 2006 ,Accepted 7 February 2006.

References 

  1. Rizzo JD , Wingard JR , Tichelli A , et al.   Recommended screening and preventive practices for long-term survivors after hematopoietic cell transplantation (joint recommendations of the European Group for Blood and Marrow Transplantation, the Center for International Blood and Marrow Transplant Research, and the American Society of Blood and Marrow Transplantation) . Biol Blood Marrow Transplant . 2006;12:138–151
  2. Landier W , Bhatia S , Eshelman DA , et al.   Development of risk-based guidelines for pediatric cancer survivors (the Children’s Oncology Group Long-Term Follow-Up Guidelines from the Children’s Oncology Group Late Effects Committee and Nursing Discipline) . J Clin Oncol . 2004;22:4979–4990
  3. Filipovich AH , Weisdorf D , Pavletic S , et al.   National Institutes of Health consensus development project on criteria for clinical trials in chronic graft-versus-host disease: I. Diagnosis and staging working group report . Biol Blood Marrow Transplant . 2005;11:945–956
  4. Kitajima T , Imamura S . Graft-versus-host reaction enhanced by ultraviolet radiation . Arch Dermatol Res . 1993;285:499–501
  5. Vogelsang GB , Wolff D , Altomonte V , et al.   Treatment of chronic graft-versus-host disease with ultraviolet irradiation and psoralen (PUVA) . Bone Marrow Transplant . 1996;17:1061–1067
  6. Leiter U , Kaskel P , Krahn G , et al.   Psoralen plus ultraviolet-A-bath photochemotherapy as an adjunct treatment modality in cutaneous chronic graft versus host disease . Photodermatol Photoimmunol Photomed . 2002;18:183–190
  7. Hymes SR , Morison WL , Farmer ER , Walters LL , Tutschka PJ , Santos GW . Methoxsalen and ultraviolet A radiation in treatment of chronic cutaneous graft-versus-host reaction . J Am Acad Dermatol . 1985;12:30–37
  8. Wetzig T , Sticherling M , Simon JC , Hegenbart U , Niederwieser D , Al-Ali HK . Medium dose long-wavelength ultraviolet A (UVA1) phototherapy for the treatment of acute and chronic graft-versus-host disease of the skin . Bone Marrow Transplant . 2005;35:515–519
  9. Enk CD , Elad S , Vexler A , Kapelushnik J , Gorodetsky R , Kirschbaum M . Chronic graft-versus-host disease treated with UVB phototherapy . Bone Marrow Transplant . 1998;22:1179–1183
  10. Grundmann-Kollmann M , Martin H , Ludwig R , et al.   Narrowband UV-B phototherapy in the treatment of cutaneous graft versus host disease . Transplantation . 2002;74:1631–1634
  11. Elad S , Or R , Resnick I , Shapira MY . Topical tacrolimus—a novel treatment alternative for cutaneous chronic graft-versus-host disease . Transpl Int . 2003;16:665–670
  12. Ziemer M , Gruhn B , Thiele JJ , Elsner P . Treatment of extensive chronic cutaneous graft-versus-host disease in an infant with topical pimecrolimus . J Am Acad Dermatol . 2004;50:946–948
  13. Smith APS , Fife CE . Advanced therapeutics (the biochemistry and biophysical basis of wound products) . In:  Sheffield PJ editors. Wound Care Practice . Flagstaff AZ: Best Publishing Company; 2004;p. 685–730
  14. Woo SB , Lee SJ , Schubert MM . Graft-vs.-host disease . Crit Rev Oral Biol Med . 1997;8:201–216
  15. Voute AB , Schulten EA , Langendijk PN , Kostense PJ , van der Waal I . Fluocinonide in an adhesive base for treatment of oral lichen planus.A double-blind, placebo-controlled clinical study . Oral Surg Oral Med Oral Pathol . 1993;75:181–185
  16. Wolff D , Anders V , Corio R , et al.   Oral PUVA and topical steroids for treatment of oral manifestations of chronic graft-vs.-host disease . Photodermatol Photoimmunol Photomed . 2004;20:184–190
  17. Eckardt A , Starke O , Stadler M , Reuter C , Hertenstein B . Severe oral chronic graft-versus-host disease following allogeneic bone marrow transplantation (highly effective treatment with topical tacrolimus) . Oral Oncol . 2004;40:811–814
  18. Sanchez AR , Sheridan PJ , Rogers RS . Successful treatment of oral lichen planus-like chronic graft-versus-host disease with topical tacrolimus (a case report) . J Periodontol . 2004;75:613–619
  19. Nemunaitis J , Singer JW , Buckner CD , et al.   Use of recombinant human granulocyte-macrophage colony-stimulating factor in graft failure after bone marrow transplantation . Blood . 1990;76:245–253
  20. Nagler R , Marmary Y , Krausz Y , Chisin R , Markitziu A , Nagler A . Major salivary gland dysfunction in human acute and chronic graft-versus-host disease (GVHD) . Bone Marrow Transplant . 1996;17:219–224
  21. Schubert MM , Sullivan KM , Morton TH , et al.   Oral manifestations of chronic graft-v-host disease . Arch Intern Med . 1984;144:1591–1595
  22. Nicolatou-Galitis O , Kitra V , Van Vliet-Constantinidou C , et al.   The oral manifestations of chronic graft-versus-host disease (cGVHD) in paediatric allogeneic bone marrow transplant recipients . J Oral Pathol Med . 2001;30:148–153
  23. Treister N , Woo S , Lehmann LE , O’Holleran E , Parsons S , Guinan E . Oral chronic graft-versus-host disease in pediatric patients following hematopoietic stem cell transplantation . Biol Blood Marrow Transplant . 2005;11:721–731
  24. Schubert MM , Sullivan KM . Recognition, incidence, and management of oral graft-versus-host disease . NCI Monogr . 1990;9:135–143
  25. Nagler RM , Nagler A . Major salivary gland involvement in graft-versus-host disease (considerations related to pathogenesis, the role of cytokines and therapy) . Cytokines Cell Mol Ther . 1999;5:227–232
  26. Nagler RM , Nagler A . Sialometrical and sialochemical analysis of patients with chronic graft-versus-host disease—a prolonged study . Cancer Invest . 2003;21:34–40
  27. Dajani AS , Taubert KA , Wilson W , et al.   Prevention of bacterial endocarditis (recommendations by the American Heart Association) . J Am Dent Assoc . 1997;128:1142–1151
  28. Calissendorff B , el Azazi M , Lonnqvist B . Dry eye syndrome in long-term follow-up of bone marrow transplanted patients . Bone Marrow Transplant . 1989;4:675–678
  29. Jack MK , Jack GM , Sale GE , Shulman HM , Sullivan KM . Ocular manifestations of graft-v-host disease . Arch Ophthalmol . 1983;101:1080–1084
  30. Hill JC . Slow-release artificial tear inserts in the treatment of dry eyes in patients with rheumatoid arthritis . Br J Ophthalmol . 1989;73:151–154
  31. Tanei R , Ohta Y , Ishihara S , Katsuoka K , Yokono H , Motoori T . Transfusion-associated graft-versus-host disease (an in situ hybridization analysis of the infiltrating donor-derived cells in the cutaneous lesion) . Dermatology . 1999;199:20–24
  32. Hart DE , Simko M , Harris E . How to produce moisture chamber eyeglasses for the dry eye patient . J Am Optom Assoc . 1994;65:517–522
  33. Frucht-Pery J , Sagi E , Hemo I , Ever-Hadani P . Efficacy of doxycycline and tetracycline in ocular rosacea . Am J Ophthalmol . 1993;116:88–92
  34. Cosar CB , Cohen EJ , Rapuano CJ , et al.   Tarsorrhaphy (clinical experience from a cornea practice) . Cornea . 2001;20:787–791
  35. Rosenthal P , Cotter JM , Baum J . Treatment of persistent corneal epithelial defect with extended wear of a fluid-ventilated gas-permeable scleral contact lens . Am J Ophthalmol . 2000;130:33–41
  36. American Academy of Ophthalmology . Punctal occlusion for the dry eye.Three-year revision . Ophthalmology . 1997;104:1521–1524
  37. Altan-Yaycioglu R , Gencoglu EA , Akova YA , Dursun D , Cengiz F , Akman A . Silicone versus collagen plugs for treating dry eye (results of a prospective randomized trial including lacrimal scintigraphy) . Am J Ophthalmol . 2005;140:88–93
  38. Hutnik CM , Probst LE . Argon laser punctal therapy versus thermal cautery for the treatment of aqueous deficiency dry eye syndrome . Can J Ophthalmol . 1998;33:365–372
  39. Marsh P , Pflugfelder SC . Topical nonpreserved methylprednisolone therapy for keratoconjunctivitis sicca in Sjogren syndrome . Ophthalmology . 1999;106:811–816
  40. Robinson MR , Lee SS , Rubin BI , et al.   Topical corticosteroid therapy for cicatricial conjunctivitis associated with chronic graft-versus-host disease . Bone Marrow Transplant . 2004;33:1031–1035
  41. Sall K , Stevenson OD , Mundorf TK , Reis BL . Two multicenter, randomized studies of the efficacy and safety of cyclosporine ophthalmic emulsion in moderate to severe dry eye disease. CsA Phase 3 Study Group . Ophthalmology . 2000;107:631–639
  42. Kojima T , Ishida R , Dogru M , et al.   The effect of autologous serum eyedrops in the treatment of severe dry eye disease (a prospective randomized case-control study) . Am J Ophthalmol . 2005;139:242–246
  43. Ogawa Y , Okamoto S , Mori T , et al.   Autologous serum eye drops for the treatment of severe dry eye in patients with chronic graft-versus-host disease . Bone Marrow Transplant . 2003;31:579–583
  44. Lee SJ , Vogelsang G , Gilman A , et al.   A survey of diagnosis, management, and grading of chronic GVHD . Biol Blood Marrow Transplant . 2002;8:32–39
  45. Corson SL , Sullivan K , Batzer F , August C , Storb R , Thomas ED . Gynecologic manifestations of chronic graft-versus-host disease . Obstet Gynecol . 1982;60:488–492
  46. Schubert MA , Sullivan KM , Schubert MM , et al.   Gynecological abnormalities following allogeneic bone marrow transplantation . Bone Marrow Transplant . 1990;5:425–430
  47. Spiryda LB , Laufer MR , Soiffer RJ , Antin JA . Graft-versus-host disease of the vulva and/or vagina (diagnosis and treatment) . Biol Blood Marrow Transplant . 2003;9:760–765
  48. Anderson M , Kutzner S , Kaufman RH . Treatment of vulvovaginal lichen planus with vaginal hydrocortisone suppositories . Obstet Gynecol . 2002;100:359–362
  49. Cribier B , Frances C , Chosidow O . Treatment of lichen planus. An evidence-based medicine analysis of efficacy . Arch Dermatol . 1998;134:1521–1530
  50. Jacobsohn DA , Margolis J , Doherty J , Anders V , Vogelsang GB . Weight loss and malnutrition in patients with chronic graft-versus-host disease . Bone Marrow Transplant . 2002;29:231–236
  51. Akpek G , Lee SJ , Flowers ME , et al.   Performance of a new clinical grading system for chronic graft-versus-host disease (a multicenter study) . Blood . 2003;102:802–809
  52. Appelbaum FR . Indications for bone marrow transplantation (BMT) in the treatment of acute myeloid leukemia (AML) . Leukemia . 1993;7:1081
  53. Zauner C , Rabitsch W , Schneeweiss B , et al.   Energy and substrate metabolism in patients with chronic extensive graft-versus-host disease . Transplantation . 2001;71:524–528
  54. Chien JW , Martin PJ , Gooley TA , et al.   Airflow obstruction after myeloablative allogeneic hematopoietic stem cell transplantation . Am J Respir Crit Care Med . 2003;168:208–214
  55. Chien JW , Martin PJ , Flowers ME , Nichols WG , Clark JG . Implications of early airflow decline after myeloablative allogeneic stem cell transplantation . Bone Marrow Transplant . 2004;33:759–764
  56. Kerstjens HA , Brand PL , Hughes MD , et al.  Dutch Chronic Non-Specific Lung Disease Study Group   A comparison of bronchodilator therapy with or without inhaled corticosteroid therapy for obstructive airways disease . N Engl J Med . 1992;327:1413–1419
  57. Sullivan KM . Immunomodulation in allogeneic marrow transplantation (use of intravenous immune globulin to suppress acute graft-versus-host disease) . Clin Exp Immunol . 1996;104(suppl 1):43–48
  58. ATS statement (guidelines for the six-minute walk test) . Am J Respir Crit Care Med . 2002;166:111–117
  59. Vogelsang GB . How I treat chronic graft-versus-host disease . Blood . 2001;97:1196–1201
  60. Chien JW , Madtes DK , Clark JG . Pulmonary function testing prior to hematopoietic stem cell transplantation . Bone Marrow Transplant . 2005;35:429–435
  61. Freudenberger TD , Madtes DK , Curtis JR , Cummings P , Storer BE , Hackman RC . Association between acute and chronic graft-versus-host disease and bronchiolitis obliterans organizing pneumonia in recipients of hematopoietic stem cell transplants . Blood . 2003;102:3822–3828
  62. Crawford SW , Fisher L . Predictive value of pulmonary function tests before marrow transplantation . Chest . 1992;101:1257–1264
  63. American Thoracic Society . Single-breath carbon monoxide diffusing capacity (transfer factor). Recommendations for a standard technique—1995 update . Am J Respir Crit Care Med . 1995;152:2185–2198
  64. Crapo RO , Morris AH , Gardner RM . Reference spirometric values using techniques and equipment that meet ATS recommendations . Am Rev Respir Dis . 1981;123:659–664
  65. Hsu KH , Jenkins DE , Hsi BP , et al.   Ventilatory functions of normal children and young adults—Mexican-American, white, and black. I. Spirometry . J Pediatr . 1979;95:14–23
  66. Bierling P , Cordonnier C , Fromont P , et al.   Acquired autoimmune thrombocytopenia after allogeneic bone marrow transplantation . Br J Haematol . 1985;59:643–646
  67. Hartert A , Willenbacher W , Gunzelmann S , et al.   Successful treatment of thrombocytopenia and hemolytic anemia with IvIG in a patient with lupus-like syndrome after mismatched related PBSCT . Bone Marrow Transplant . 2001;27:337–340
  68. Keung YK , Cobos E , Bolanos-Meade J , Issarachai S , Brideau A , Morgan D . Evans syndrome after autologous bone marrow transplant for recurrent Hodgkin’s disease . Bone Marrow Transplant . 1997;20:1099–1101
  69. Khouri IF , Ippoliti C , Gajewski J , Przepiorka D , Champlin RE . Neutropenias following allogeneic bone marrow transplantation (response to therapy with high-dose intravenous immunoglobulin) . Am J Hematol . 1996;52:313–315
  70. Akpek G . Clinical grading in chronic graft-versus-host disease (is it time for change?) . Leuk Lymphoma . 2002;43:1211–1220
  71. Daneshpouy M , Socie G , Lemann M , Rivet J , Gluckman E , Janin A . Activated eosinophils in upper gastrointestinal tract of patients with graft-versus-host disease . Blood . 2002;99:3033–3040
  72. McNeel D , Rubio MT , Damaj G , et al.   Hypereosinophilia as a presenting sign of acute graft-versus-host disease after allogeneic bone marrow transplantation . Transplantation . 2002;74:1797–1800
  73. Masumoto A , Sasao T , Yoshiba F , et al.   [Hypereosinophilia after allogeneic bone marrow transplantation.A possible role of IL-5 overproduction by donor T-cells chronic GVHD.] . Rinsho Ketsueki . 1997;38:234–236
  74. Jacobsohn DA , Schechter T , Seshadri R , Thormann K , Duerst R , Kletzel M . Eosinophilia correlates with the presence or development of chronic graft-versus-host disease in children . Transplantation . 2004;77:1096–1100
  75. Openshaw HNS . Neurologic Complications . In:  Forman SJ ,  Blume KG ,  Thomas ED editor. Hematopoietic Cell Transplantation . 3rd ed.. Malden, MA: Blackwell Scientific Publications; 2004;p. 811–823
  76. Ma M , Barnes G , Pulliam J , Jezek D , Baumann RJ , Berger JR . CNS angiitis in graft vs host disease . Neurology . 2002;59:1994–1997
  77. Padovan CS , Gerbitz A , Sostak P , et al.   Cerebral involvement in graft-versus-host disease after murine bone marrow transplantation . Neurology . 2001;56:1106–1108
  78. Sostak P , Padovan CS , Yousry TA , Ledderose G , Kolb HJ , Straube A . Prospective evaluation of neurological complications after allogeneic bone marrow transplantation . Neurology . 2003;60:842–848
  79. Max MB , Culnane M , Schafer SC , et al.   Amitriptyline relieves diabetic neuropathy pain in patients with normal or depressed mood . Neurology . 1987;37:589–596
  80. Sindrup SH , Gram LF , Brosen K , Eshoj O , Mogensen EF . The selective serotonin reuptake inhibitor paroxetine is effective in the treatment of diabetic neuropathy symptoms . Pain . 1990;42:135–144
  81. Backonja M , Beydoun A , Edwards KR , et al.   Gabapentin for the symptomatic treatment of painful neuropathy in patients with diabetes mellitus (a randomized controlled trial) . JAMA . 1998;280:1831–1836
  82. Max MB , Schafer SC , Culnane M , Dubner R , Gracely RH . Association of pain relief with drug side effects in postherpetic neuralgia (a single-dose study of clonidine, codeine, ibuprofen, and placebo) . Clin Pharmacol Ther . 1988;43:363–371
  83. Lefvert AK , Bjorkholm M . Antibodies against the acetylcholine receptor in hematologic disorders (implications for the development of myasthenia gravis after bone marrow grafting) . N Engl J Med . 1987;317:170
  84. Couriel DR , Beguelin GZ , Giralt S , et al.   Chronic graft-versus-host disease manifesting as polymyositis (an uncommon presentation) . Bone Marrow Transplant . 2002;30:543–546
  85. Anderson BA , Young PV , Kean WF , Ludwin SK , Galbraith PR , Anastassiades TP . Polymyositis in chronic graft vs host disease. A case report . Arch Neurol . 1982;39:188–190
  86. Parker P , Chao NJ , Ben-Ezra J , et al.   Polymyositis as a manifestation of chronic graft-versus-host disease . Medicine (Baltimore) . 1996;75:279–285
  87. Roy V , Ochs L , Weisdorf D . Late infections following allogeneic bone marrow transplantation (suggested strategies for prophylaxis) . Leuk Lymphoma . 1997;26:1–15
  88. Martin PJ , Carpenter PA , Sanders JE , Flowers ME . Diagnosis and clinical management of chronic graft-versus-host disease . Int J Hematol . 2004;79:221–228
  89. Wingard JR , Vogelsang GB , Deeg HJ . Stem cell transplantation (supportive care and long-term complications) . Hematology (Am Soc Hematol Educ Program) . 2002;422–444
  90. Guidelines for preventing opportunistic infections among hematopoietic stem cell transplant recipients . MMWR Recomm Rep . 2000;49:1–125 CE121-127
  91. Haddad PA , Repka TL , Weisdorf DJ . Penicillin-resistant Streptococcus pneumoniae septic shock and meningitis complicating chronic graft versus host disease (a case report and review of the literature) . Am J Med . 2002;113:152–155
  92. Kulkarni S , Powles R , Treleaven J , et al.   Chronic graft versus host disease is associated with long-term risk for pneumococcal infections in recipients of bone marrow transplants . Blood . 2000;95:3683–3686
  93. Molrine DC , Antin JH , Guinan EC , et al.   Donor immunization with pneumococcal conjugate vaccine and early protective antibody responses following allogeneic hematopoietic cell transplantation . Blood . 2003;101:831–836
  94. Nachman S , Kim S , King J , et al.   Safety and immunogenicity of a heptavalent pneumococcal conjugate vaccine in infants with human immunodeficiency virus type 1 infection . Pediatrics . 2003;112:66–73
  95. Shinefield H , Black S , Ray P , Fireman B , Schwalbe J , Lewis E . Efficacy, immunogenicity and safety of heptavalent pneumococcal conjugate vaccine in low birth weight and preterm infants . Pediatr Infect Dis J . 2002;21:182–186
  96. Winston DJ , Antin JH , Wolff SN , et al.   A multicenter, randomized, double-blind comparison of different doses of intravenous immunoglobulin for prevention of graft-versus-host disease and infection after allogeneic bone marrow transplantation . Bone Marrow Transplant . 2001;28:187–196
  97. Cordonnier C , Chevret S , Legrand M , et al.   Should immunoglobulin therapy be used in allogeneic stem-cell transplantation? A randomized, double-blind, dose effect, placebo-controlled, multicenter trial . Ann Intern Med . 2003;139:8–18
  98. Cooperative Group for the Study of Immunoglobulin in Chronic Lymphocytic Leukemia . Intravenous immunoglobulin for the prevention of infection in chronic lymphocytic leukemia. A randomized, controlled clinical trial . N Engl J Med . 1988;319:902–907
  99. The National Institute of Child Health and Human Developments Intravenous Immunoglobulin Study Group . Intravenous immune globulin for the prevention of bacterial infections in children with symptomatic human immunodeficiency virus infection . N Engl J Med . 1991;325:73–80
  100. Magny JF , Bremard-Oury C , Brault D , et al.   Intravenous immunoglobulin therapy for prevention of infection in high-risk premature infants (report of a multicenter, double-blind study) . Pediatrics . 1991;88:437–443
  101. Leather HL , Wingard JR . Prophylaxis, empirical therapy, or pre-emptive therapy of fungal infections in immunocompromised patients (which is better for whom?) . Curr Opin Infect Dis . 2002;15:369–375
  102. Souza JP , Boeckh M , Gooley TA , Flowers ME , Crawford SW . High rates of Pneumocystis carinii pneumonia in allogeneic blood and marrow transplant recipients receiving dapsone prophylaxis . Clin Infect Dis . 1999;29:1467–1471
  103. Lyytikainen O , Ruutu T , Volin L , et al.   Late onset Pneumocystis carinii pneumonia following allogeneic bone marrow transplantation . Bone Marrow Transplant . 1996;17:1057–1059
  104. Marras TK , Sanders K , Lipton JH , Messner HA , Conly J , Chan CK . Aerosolized pentamidine prophylaxis for Pneumocystis carinii pneumonia after allogeneic marrow transplantation . Transpl Infect Dis . 2002;4:66–74
  105. Perren TJ , Powles RL , Easton D , Stolle K , Selby PJ . Prevention of herpes zoster in patients by long-term oral acyclovir after allogeneic bone marrow transplantation . Am J Med . 1988;85:99–101
  106. Kanda Y , Mineishi S , Saito T , et al.   Long-term low-dose acyclovir against varicella-zoster virus reactivation after allogeneic hematopoietic stem cell transplantation . Bone Marrow Transplant . 2001;28:689–692
  107. Boeckh MKHW , Flowers ME , Meyers JD , Bowden RA . Long-term acyclovir for prevention of varicella zoster virus disease after allogeneic hematopoietic cell transplantation—a randomized double-blind placebo controlled study . Blood . 2006;107:1800–1805
  108. Yoo JH , Lee DG , Choi SM , et al.   Infectious complications and outcomes after allogeneic hematopoietic stem cell transplantation in Korea . Bone Marrow Transplant . 2004;34:497–504
  109. Boeckh M , Leisenring W , Riddell SR , et al.   Late cytomegalovirus disease and mortality in recipients of allogeneic hematopoietic stem cell transplants (importance of viral load and T-cell immunity) . Blood . 2003;101:407–414
  110. Sintchenko V , Gilbert GL , Coiera E , Dwyer D . Treat or test first? Decision analysis of empirical antiviral treatment of influenza virus infection versus treatment based on rapid test results . J Clin Virol . 2002;25:15–21
  111. Rothberg MB , Bellantonio S , Rose DN . Management of influenza in adults older than 65 years of age (cost-effectiveness of rapid testing and antiviral therapy) . Ann Intern Med . 2003;139:321–329
  112. Courneya KS , Keats MR , Turner AR . Physical exercise and quality of life in cancer patients following high dose chemotherapy and autologous bone marrow transplantation . Psychooncology . 2000;9:127–136
  113. Janin A , Socie G , Devergie A , et al.   Fasciitis in chronic graft-versus-host disease. A clinicopathologic study of 14 cases . Ann Intern Med . 1994;120:993–998
  114. Dimeo F , Bertz H , Finke J , Fetscher S , Mertelsmann R , Keul J . An aerobic exercise program for patients with haematological malignancies after bone marrow transplantation . Bone Marrow Transplant . 1996;18:1157–1160
  115. Dimeo FC , Stieglitz RD , Novelli-Fischer U , Fetscher S , Keul J . Effects of physical activity on the fatigue and psychologic status of cancer patients during chemotherapy . Cancer . 1999;85:2273–2277
  116. Mello M , Tanaka C , Dulley FL . Effects of an exercise program on muscle performance in patients undergoing allogeneic bone marrow transplantation . Bone Marrow Transplant . 2003;32:723–728
  117. Castaneda S , Carmona L , Carvajal I , Arranz R , Diaz A , Garcia-Vadillo A . Reduction of bone mass in women after bone marrow transplantation . Calcif Tissue Int . 1997;60:343–347
  118. Schimmer AD , Mah K , Bordeleau L , et al.   Decreased bone mineral density is common after autologous blood or marrow transplantation . Bone Marrow Transplant . 2001;28:387–391
  119. Schimmer AD , Minden MD , Keating A . Osteoporosis after blood and marrow transplantation (clinical aspects) . Biol Blood Marrow Transplant . 2000;6:175–181
  120. Kerschan-Schindl K , Mitterbauer M , Fureder W , et al.   Bone metabolism in patients more than five years after bone marrow transplantation . Bone Marrow Transplant . 2004;34:491–496
  121. Kang MI , Lee WY , Oh KW , et al.   The short-term changes of bone mineral metabolism following bone marrow transplantation . Bone . 2000;26:275–279
  122. Stern JM , Chesnut CH , Bruemmer B , et al.   Bone density loss during treatment of chronic GVHD . Bone Marrow Transplant . 1996;17:395–400
  123. Stern JM , Sullivan KM , Ott SM , et al.   Bone density loss after allogeneic hematopoietic stem cell transplantation (a prospective study) . Biol Blood Marrow Transplant . 2001;7:257–264
  124. Chapuy MC , Meunier PJ . Prevention and treatment of osteoporosis . Aging (Milano) . 1995;7:164–173
  125. Dawson-Hughes B , Harris SS , Krall EA , Dallal GE . Effect of calcium and vitamin D supplementation on bone density in men and women 65 years of age or older . N Engl J Med . 1997;337:670–676
  126. Delmas PD . Treatment of postmenopausal osteoporosis . Lancet . 2002;359:2018–2026
  127. Cauley JA , Robbins J , Chen Z , et al.   Effects of estrogen plus progestin on risk of fracture and bone mineral density (the Women’s Health Initiative randomized trial) . JAMA . 2003;290:1729–1738
  128. Delmas PD . The use of bisphosphonates in the treatment of osteoporosis . Curr Opin Rheumatol . 2005;17:462–466
  129. Chiodi S , Spinelli S , Ravera G , et al.   Quality of life in 244 recipients of allogeneic bone marrow transplantation . Br J Haematol . 2000;110:614–619
  130. Kiss TL , Abdolell M , Jamal N , Minden MD , Lipton JH , Messner HA . Long-term medical outcomes and quality-of-life assessment of patients with chronic myeloid leukemia followed at least 10 years after allogeneic bone marrow transplantation . J Clin Oncol . 2002;20:2334–2343
  131. Syrjala KL , Chapko MK , Vitaliano PP , Cummings C , Sullivan KM . Recovery after allogeneic marrow transplantation (prospective study of predictors of long-term physical and psychosocial functioning) . Bone Marrow Transplant . 1993;11:319–327
  132. Worel N , Biener D , Kalhs P , et al.   Long-term outcome and quality of life of patients who are alive and in complete remission more than two years after allogeneic and syngeneic stem cell transplantation . Bone Marrow Transplant . 2002;30:619–626
  133. Beanlands HJ , Lipton JH , McCay EA , et al.   Self-concept as a “BMT patient”, illness intrusiveness, and engulfment in allogeneic bone marrow transplant recipients . J Psychosom Res . 2003;55:419–425
  134. Andrykowski MA , Bishop MM , Hahn EA , et al.   Long-term health-related quality of life, growth, and spiritual well-being after hematopoietic stem-cell transplantation . J Clin Oncol . 2005;23:599–608
  135. Heinonen H , Volin L , Zevon MA , Uutela A , Barrick C , Ruutu T . Stress among allogeneic bone marrow transplantation patients . Patient Educ Couns . 2005;56:62–71
  136. Deeg HJ , Leisenring W , Storb R , et al.   Long-term outcome after marrow transplantation for severe aplastic anemia . Blood . 1998;91:3637–3645
  137. Edman L , Larsen J , Hagglund H , Gardulf A . Health-related quality of life, symptom distress and sense of coherence in adult survivors of allogeneic stem-cell transplantation . Eur J Cancer Care (Engl) . 2001;10:124–130
  138. Lesko LM , Ostroff JS , Mumma GH , Mashberg DE , Holland JC . Long-term psychological adjustment of acute leukemia survivors (impact of bone marrow transplantation versus conventional chemotherapy) . Psychosom Med . 1992;54:30–47
  139. Watson M , Buck G , Wheatley K , et al.   Adverse impact of bone marrow transplantation on quality of life in acute myeloid leukaemia patients; analysis of the UK Medical Research Council AML 10 Trial . Eur J Cancer . 2004;40:971–978
  140. Kopp M , Holzner B , Meraner V , et al.   Quality of life in adult hematopoietic cell transplant patients at least 5 yr after treatment (a comparison with healthy controls) . Eur J Haematol . 2005;74:304–308
  141. Norris J , Kunes-Connell M , Spelic SS . A grounded theory of reimaging . ANS Adv Nurs Sci . 1998;20:1–12
  142. Neitzert CS , Ritvo P , Dancey J , Weiser K , Murray C , Avery J . The psychosocial impact of bone marrow transplantation (a review of the literature) . Bone Marrow Transplant . 1998;22:409–422
  143. Mock V . Fatigue management (evidence and guidelines for practice) . Cancer . 2001;92:1699–1707
  144. Payne JK . A neuroendocrine-based regulatory fatigue model . Biol Res Nurs . 2004;6:141–150
  145. Hjermstad MJ , Knobel H , Brinch L , et al.   A prospective study of health-related quality of life, fatigue, anxiety and depression 3-5 years after stem cell transplantation . Bone Marrow Transplant . 2004;34:257–266
  146. Sutherland HJ , Fyles GM , Adams G , et al.   Quality of life following bone marrow transplantation (a comparison of patient reports with population norms) . Bone Marrow Transplant . 1997;19:1129–1136

 The opinions expressed here are those of the authors and do not represent the official position of the National Institutes of Health, Food and Drug Administration, or the United States Government.

PII: S1083-8791(06)00161-3

doi: 10.1016/j.bbmt.2006.02.003

Biology of Blood and Marrow Transplantation
Volume 12, Issue 4 , Pages 375-396 , April 2006