Biology of Blood and Marrow Transplantation
Volume 12, Issue 6 , Pages 672-682 , June 2006

Acute Radiation Injury: Contingency Planning for Triage, Supportive Care, and Transplantation

Presented in part at a workshop held at the Tandem BMT Meetings; Keystone, Colorado; February 2005.

  • Daniel Weisdorf

      Affiliations

    • University of Minnesota, Minneapolis, Minnesota
    • Corresponding Author InformationCorrespondence and reprint requests: Daniel Weisdorf, MD, Department of Medicine, University of Minnesota, 420 Delaware Street, SE, MMC, 480, Minneapolis, MN 55455
    • ,
  • Nelson Chao

      Affiliations

    • Duke University Medical Center, Durham, North Carolina
    • ,
  • Jamie K. Waselenko

      Affiliations

    • Sarah Cannon Research Institute, Nashville, Tennessee
    • ,
  • Nicholas Dainiak

      Affiliations

    • Department of Medicine, Bridgeport Hospital and Yale University School of Medicine, New Haven, Connecticut
    • ,
  • James O. Armitage

      Affiliations

    • Division of Hematology/Oncology, University of Nebraska, Omaha, Nebraska
    • ,
  • Ian McNiece

      Affiliations

    • Division of Biomedical Sciences John Hopkins Singapore, Singapore, Singapore
    • ,
  • Dennis Confer

      Affiliations

    • National Marrow Donor Program, Minneapolis, Minnesota

Received 4 January 2006 ,Accepted 7 February 2006.

  • Image Result

    Hypothetical blood count recovery based on allogeneic HCT (dashed/dotted line) or autologous recovery after lesser exposure (solid line), perhaps supported by early cytokine therapy. ANC, absolute neu

    Hypothetical blood count recovery based on allogeneic HCT (dashed/dotted line) or autologous recovery after lesser exposure (solid line), perhaps supported by early cytokine therapy. ANC, absolute neutrophil count.

  • Image Result
    Leukocyte count based on exposure dose in patients who were exposed to radiation in Chernobyl. Note the abortive increase (transient increase before decrease) in leukocytes, which are primarily compos

    Leukocyte count based on exposure dose in patients who were exposed to radiation in Chernobyl. Note the abortive increase (transient increase before decrease) in leukocytes, which are primarily composed of granulocytes, in doses <500 rad (<5 Gy). Onset of neutropenia may not occur for weeks, especially with lower exposures, and duration of neutropenia may be prolonged. Reprinted with permission from Vorobiev [9].

PII: S1083-8791(06)00162-5

doi: 10.1016/j.bbmt.2006.02.006

Biology of Blood and Marrow Transplantation
Volume 12, Issue 6 , Pages 672-682 , June 2006

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