Biology of Blood and Marrow Transplantation
Volume 12, Issue 6 , Pages 683-687 , June 2006

Outcomes of Transplantation with Related- and Unrelated-Donor Stem Cells in Children with Severe Thalassemia

  • Suradej Hongeng

      Affiliations

    • Department of Pediatrics, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
    • Bone Marrow Transplantation Program, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
    • Corresponding Author InformationCorrespondence and reprint requests: Suradej Hongeng, MD, Department of Pediatrics, Faculty of Medicine, Ramathibodi Hospital, Rama VI Road, Bangkok 10400, Thailand
    • ,
  • Samart Pakakasama

      Affiliations

    • Department of Pediatrics, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
    • Bone Marrow Transplantation Program, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
    • ,
  • Ampaiwan Chuansumrit

      Affiliations

    • Department of Pediatrics, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
    • ,
  • Nongnuch Sirachainan

      Affiliations

    • Department of Pediatrics, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
    • Bone Marrow Transplantation Program, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
    • ,
  • Pimpan Kitpoka

      Affiliations

    • Department of Pathology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
    • ,
  • Umaporn Udomsubpayakul

      Affiliations

    • Research Center, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
    • ,
  • Artit Ungkanont

      Affiliations

    • Department of Internal Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
    • Bone Marrow Transplantation Program, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
    • ,
  • Saengsuree Jootar

      Affiliations

    • Department of Internal Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
    • Bone Marrow Transplantation Program, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand

Received 8 November 2005 ,Accepted 13 February 2006.

References 

  1. Anasetti C , Etzioni R , Petersdorf EW , Martin PJ , Hansen JA . Marrow transplantation from unrelated volunteer donors . Annu Rev Med . 1995;46:169–179
  2. La Nasa G , Giardini C , Argiolu F , et al.   Unrelated donor bone marrow transplantation for thalassemia (the effect of extended haplotypes) . Blood . 2002;99:4350–4356
  3. Hongeng S , Pakakasama S , Chaisiripoomkere W , et al.   Outcome of transplantation with unrelated donor bone marrow in children with severe thalassemia . Bone Marrow Transplant . 2004;33:377–379
  4. Hongeng S , Chuansumrit A , Hathirat P , Rerkamnuaychoke B , Chaisiripoomkere W , Jootar S . Full chimerism in nonmyeloablative stem cell transplantation in a β-thalassemia major patient (class 3 Lucarelli) . Bone Marrow Transplant . 2002;30:299–314
  5. Hongeng S , Pakakasama S , Chaisiripoomkere W , Ungkanont A , Jootar S . Nonmyeloablative stem cell transplantation with haploidentical donor in a class 3 Lucarelli severe thalassemia patient . Bone Marrow Transplant . 2004;34:271–272
  6. Lucarelli G , Giardini C , Angelucci E . Bone marrow transplantation in thalassemia . In:  Winter JN editors. Blood Stem Cell Transplantation . Boston: Kluwer Academic; 1997;p. 305–315
  7. Smith BR , Parkman R , Lipton J , Nathan DG , Rappeport JM . Efficacy of a short course (four doses) of methotrexate following bone marrow transplantation for prevention of graft-versus-host disease . Transplantation . 1985;39:326–329
  8. Willenbacher W , Basara N , Blau IW , Fauser AA , Kiehl MG . Treatment of steroid refractory acute and chronic graft-versus-host disease with daclizumab . Br J Haematol . 2001;112:820–823
  9. G Kobbe , P Schneider , U Rohr , et al.   Treatment of severe steroid refractory acute graft-versus-host disease with infliximab, a chimeric human/mouse antiTNFalpha antibody . Bone Marrow Transplant . 2001;28:47–49
  10. Le Blanc K , Rasmusson I , Sunberg B , et al.   Treatment of severe graft-versus-host disease with third party haploidentical mesenchymal stem cells . Lancet . 2004;363:1439–1441
  11. Boeckh M , Nichols WG , Papanicolaou G , Rubin R , Wingard JR , Zaia J . Cytomegalovirus in hematopoietic stem cell transplant recipients (current status, known challenges, and future strategies) . Biol Blood MarrowTransplant . 2003;9:543–558
  12. van Esser JW , Niesters HG , van der Holt B , et al.   Prevention of Epstein-Barr virus-lymphoproliferative disease by molecular monitoring and preemptive rituximab in high-risk patients after allogeneic stem cell transplantation . Blood . 2002;99:4364–4369
  13. Gaziev D , Galimberti M , Lucarelli G , et al.   Bone marrow transplantation from alternative donors for thalassemia (HLA-phenotypically identical relative and HLA-nonidentical sibling or parent transplants) . Bone Marrow Transplant . 2000;25:815–821
  14. Hongeng S , Krance RA , Bowman LC , et al.   Outcome of transplantation with matched-sibling and unrelated donor bone marrow in children with leukemia . Lancet . 1997;350:767–771

PII: S1083-8791(06)00181-9

doi: 10.1016/j.bbmt.2006.02.008

Biology of Blood and Marrow Transplantation
Volume 12, Issue 6 , Pages 683-687 , June 2006

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