Biology of Blood and Marrow Transplantation
Volume 12, Issue 6 , Pages 599-602 , June 2006

Reduced Intensity Conditioning for Allogeneic Stem Cell Transplantation in Relapsed and Refractory Hodgkin Lymphoma: Where Do We Stand?

Received 3 October 2005 ,Accepted 28 March 2006.

References 

  1. Champlin R , Khouri I , Kornblau S , et al.   Allogeneic hematopoietic transplantation as adoptive immunotherapy, induction of graft-versus-malignancy as primary therapy . Hematol Oncol Clin North Am . 1999;13:1041–1057
  2. Martino R , Sierra J . Allogeneic hematopoietic stem cell transplantation after immunosuppressive but non-myeloablative conditioning (“miniallografts” are no small matter) . Haematologica . 1998;83:865–867
  3. Gajewski JL , Phillips GL , Sobocinski KA , et al.   Bone marrow transplants from HLA-identical siblings in advanced Hodgkin’s disease . J Clin Oncol . 1996;14:572–578
  4. Anderson JE , Litzow MR , Appelbaum FR , et al.   Allogeneic, syngeneic and autologous marrow transplantation for Hodgkin’s disease (the 21-year Seattle experience) . J Clin Oncol . 1993;11:2342–2350
  5. Milpied N , Fielding AK , Pearce R , et al.  European Group for Blood and Marrow Transplantation   Allogeneic bone marrow transplant is not better than autologous transplant for patients with relapsed Hodgkin’s disease . J Clin Oncol . 1996;14:1291–1296
  6. Akpek G , Ambinder RF , Piantadosi S , et al.   Long-term results of blood and marrow transplantation for Hodgkin’s lymphoma . J Clin Oncol . 2001;19:4314–4321
  7. Peniket AJ , Ruiz de Elvira MC , Taghipour G , et al.   An EBMT registry matched study of allogeneic stem cell transplants for lymphoma (allogeneic transplantation is associated with a lower relapse rate but a higher procedure-related mortality rate than autologous transplantation) . Bone Marrow Transplant . 2003;31:667–678
  8. Peggs KS , Hunter A , Chopra R , et al.   Clinical evidence of a graft-versus-lymphoma effect after reduced-intensity allogeneic transplantation . Lancet . 2005;365:1906–1908
  9. Robinson SP , Taghipour G , Sureda A . Reduced-intensity allogeneic stem cell transplantation for Hodgkin’s disease (Outcome depends primarily on disease status at the time of transplantation) . (abstract) Blood . 2004;104:639a
  10. Carella AM , Cavaliere M , Lerma E , et al.   Autografting followed by non-myeloablative immunosuppressive chemotherapy and allogeneic peripheral-blood hematopoietic stem-cell transplantation as treatment of resistant Hodgkin’s disease and non-Hodgkin’s lymphoma . J Clin Oncol . 2000;18:3918–3924
  11. Burroughs LM , Maris MB , Sandmaier BM , et al.   HLA-matched related or unrelated donor non-myeloablative conditioning and hematopoietic cell transplant for patients with advanced Hodgkin’s disease . Biol Blood Marrow Transplant . 2004;10(suppl 1):73
  12. Peggs KS , Thomson K , Chopra R , et al.   Long term results of reduced intensity transplantation in multiply relapsed and refractory Hodgkin’s lymphoma (evidence of a therapeutically relevant graft-versus-lymphoma effect) . (abstract) Blood . 2003;102:198a
  13. Alvarez I , Sureda A , Caballero MD , et al.   Nonmyeloablative stem cell transplantation is an effective therapy for refractory or relapsed Hodgkin lymphoma (results of a Spanish Prospective Cooperative Protocol) . Biol Blood Marrow Transplant . 2006;12:172–183
  14. Anderlini P , Saliba R , Acholonu S , et al.   Reduced-intensity allogeneic stem cell transplantation in relapsed and refractory Hodgkin’s disease (low transplant-related mortality and impact of intensity of conditioning regimen) . Bone Marrow Transplant . 2005;35:943–951
  15. Linch DC , Winfield D , Goldstone AH , et al.   Dose intensification with autologous bone marrow transplantation in relapsed and resistant Hodgkin’s disease (results of a BNLI randomised trial) . Lancet . 1993;341:1051–1054
  16. Schmitz N , Pfistner B , Sextro M , et al.   Aggressive conventional chemotherapy compared with autologous haemopoietic stem-cell transplantation for relapsed chemosensitive Hodgkin’s disease (a randomized trial) . Lancet . 2002;359:2065–2071
  17. Porter DL , Luger SM , Duffy KM , et al.   Allogeneic cell therapy for patients who relapse after autologous stem cell transplantation . Biol Blood Marrow Transplant . 2001;7:230–238
  18. Anderlini P , Acholonu SA , Okoroji GJ , et al.   Donor leukocyte infusions in relapsed Hodgkin’s lymphoma following allogeneic stem cell transplantation (CD3+ cell dose, GVHD and disease response) . Bone Marrow Transplant . 2004;34:511–514

PII: S1083-8791(06)00292-8

doi: 10.1016/j.bbmt.2006.03.013

Biology of Blood and Marrow Transplantation
Volume 12, Issue 6 , Pages 599-602 , June 2006

Article Tools