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Biology of Blood and Marrow Transplantation
Volume 12, Issue 8
, Pages 795-807
, August 2006
Role of Allogeneic Stem Cell Transplantation for Adult Chronic Myeloid Leukemia in the Imatinib Era
References
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Beneficial effects of cytogenetic and molecular response on long-term outcome in patients with newly diagnosed chronic myeloid leukemia in chronic phase (CML-CP) treated with imatinib (IM)
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[abstract]
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BCR-ABL levels continue to decrease up to 42 months after commencement of standard dose imatinib in patients with newly diagnosed chronic phase CML who achieve a major molecular response
.
[abstract]
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The frequency of detection of BCR-ABL mutations in imatinib treated patients with chronic phase CML who attain a complete cytogenetic response (CCR) does not diminish with increasing duration of CCR but the associated loss of response is usually gradual
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Higher dose imatinib (600mg/day) with selective intensification in newly diagnosed CML patient in chronic phase; cytogenetic response rates at 12 months are superior to IRIS
.
[abstract]
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Reproductive status in long term bone marrow transplant survivors receiving busulfan-cyclophosphamide (120mg/kg)
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Frequency of major molecular responses to imatinib or interferon alfa plus cytarabine in newly diagnosed chronic myeloid leukemia
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In-vitro sensitivity to imatinib-induced inhibition of ABL kinase activity is predictive of molecular response in de-novo CML patients
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Chronic myeloid leukaemia
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.
Hematology
. 2005;174–182
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Sustained durability of response plus high rates of cytogenetic responses result in long-term benefit for newly diagnosed chronic-phase chronic myeloid leukemia (CML-CP) treated with imatinib (IM) therapy
(update from the IRIS study)
.
[abstract]
Blood
. 2004;104:21
- Dose escalation of imatinib mesylate can overcome resistance to standard dose therapy in patients with chronic myelogenous leukemia . Blood . 2003;101:473–475
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Long term observation of CML patients after imatinib resistance associated with BCR-ABL mutations
.
[abstract]
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. 2005;106:1086
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Correlation of clinical response to dasatinib (BMS-354825) with BCR-ABL mutation status in imatinib-resistant patients (pts) which chronic myeloid leukemia (CML) treated at MD Anderson Cancer Center (MDACC)
.
[abstract]
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. 2005;106:1091
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Dasatinib (BMS-354825) in patients with chronic myeloid leukemia (CML) and Philadelphia-chromosome positive acute lymphoblastic leukemia (PH+ ALL) who are resistant or intolerant to imatinib
(update of a phase 1 study)
.
[abstract]
Blood
. 2005;106:38
-
Major molecular responses to dasatinib (BMS-354825) are observed in imatinib-resistant late stage chronic and advanced CML patients
(impact and fate of imatinib-resistant clones in dasatinib-treated patients)
.
[abstract]
Blood
. 2005;106:437
-
Dasatinib (BMS-354825) has increased activity against bcr-abl compared to imatinib in primary CML cells in vitro, but does not eradicate quiescent CML stem cells
.
[abstract]
Blood
. 2005;106:695
-
AMN107, a novel aminopyrimidine inhibitor of bcr-abl, has significant activity in imatinib-resistant chronic myeloid leukemia (CML) or Philadelphia-chromosome-positive acute lymphoid leukemia (Ph+ ALL)
.
[abstract]
Blood
. 2005;106:37
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Chronic myeloid leukemia stem cells and their differentiated progeny display divergent drug sensitivities to imatinib mesylate and interferon-alpha
.
[abstract]
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. 2004;104:1996
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Probability and impact of obtaining a cytogenetic response to imatinib as initial therapy for chronic myeloid leukemia (CML) in chronic phase
.
[abstract]
Blood
. 2003;102:634
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Imatinib induces durable haematological and cytogenetic responses in patients with accelerated phase chronic myeloid leukemia
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.
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. 2005;89:1928–1937
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Sequential treatment with reduced intensity allogeneic stem cell transplantation and imatinib for chronic myelogenous leukemia (CML)
.
[abstract]
Blood
. 2004;104:812
PII: S1083-8791(06)00293-X
doi: 10.1016/j.bbmt.2006.03.012
© 2006 American Society for Blood and Marrow Transplantation. Published by Elsevier Inc. All rights reserved.
« Previous
Next »
Biology of Blood and Marrow Transplantation
Volume 12, Issue 8
, Pages 795-807
, August 2006
