Biology of Blood and Marrow Transplantation
Volume 12, Issue 12 , Pages 1302-1309 , December 2006

Hepatic Injury following Reduced Intensity Unrelated Cord Blood Transplantation for Adult Patients with Hematological Diseases

  • Eiji Kusumi

      Affiliations

    • Department of Hematology, Toranomon Hospital, Tokyo, Japan
    • Division of Exploratory Research, Institute of Medical Science, University of Tokyo, Tokyo, Japan
    • Corresponding Author InformationCorrespondence and reprint requests: Eiji Kusumi, MD, Division of Exploratory Research, Institute of Medical Science, University of Tokyo, Tokyo 1088639 Japan.
    • ,
  • Masahiro Kami

      Affiliations

    • Division of Exploratory Research, Institute of Medical Science, University of Tokyo, Tokyo, Japan
    • ,
  • Yoshinobu Kanda

      Affiliations

    • Department of Cell Therapy and Transplantation Medicine, University of Tokyo Hospital, Tokyo, Japan
    • ,
  • Naoko Murashige

      Affiliations

    • Hematopoietic Stem Cell Transplant Unit. National Cancer Center Hospital, Tokyo, Japan
    • ,
  • Kunihiko Seki

      Affiliations

    • Department of Pathology, Toranomon Hospital, Tokyo, Japan
    • ,
  • Masayo Fujiwara

      Affiliations

    • Department of Hematology, Toranomon Hospital, Tokyo, Japan
    • ,
  • Rikako Koyama

      Affiliations

    • Department of Gastroenterology, Toranomon Hospital, Tokyo, Japan
    • ,
  • Tsunehiko Komatsu

      Affiliations

    • Department of Hematology, Tsukuba Memorial Hospital, Tsukuba, Japan
    • ,
  • Akiko Hori

      Affiliations

    • Division of Exploratory Research, Institute of Medical Science, University of Tokyo, Tokyo, Japan
    • ,
  • Yuji Tanaka

      Affiliations

    • Division of Exploratory Research, Institute of Medical Science, University of Tokyo, Tokyo, Japan
    • ,
  • Koichiro Yuji

      Affiliations

    • Department of Internal Medicine, Institute of Medical Science, University of Tokyo, Tokyo, Japan
    • ,
  • Tomoko Matsumura

      Affiliations

    • Division of Exploratory Research, Institute of Medical Science, University of Tokyo, Tokyo, Japan
    • ,
  • Kazuhiro Masuoka

      Affiliations

    • Department of Hematology, Toranomon Hospital, Tokyo, Japan
    • ,
  • Atsushi Wake

      Affiliations

    • Department of Hematology, Toranomon Hospital, Tokyo, Japan
    • ,
  • Shigesaburo Miyakoshi

      Affiliations

    • Department of Hematology, Toranomon Hospital, Tokyo, Japan
    • ,
  • Shuichi Taniguchi

      Affiliations

    • Department of Hematology, Toranomon Hospital, Tokyo, Japan

Received 8 April 2006 ,Accepted 28 July 2006.

References 

  1. Strasser S, McDonald G. Hepatobiliary complications of hematopoietic cell transplantation. In:  Schiff E,  Sorrell M,  Maddrey W editor. Schiff’s Diseases of the Liver. Philadelphia: Lippincott; 2003;p. 1636–1663
  2. McDonald GB, Sharma P, Matthews DE, Shulman HM, Thomas ED. Venocclusive disease of the liver after bone marrow transplantation: diagnosis, incidence, and predisposing factors. Hepatology. 1984;4:116–122
  3. McDonald GB, Hinds MS, Fisher LD, et al. Veno-occlusive disease of the liver and multiorgan failure after bone marrow transplantation: a cohort study of 355 patients. Ann Intern Med. 1993;118:255–267
  4. Kami M, Mori S, Tanikawa S, et al. Risk factors for hepatic veno-occlusive disease after bone marrow transplantation: retrospective analysis of 137 cases at a single institution. Bone Marrow Transplant. 1997;20:397–402
  5. Jones RJ, Lee KS, Beschorner WE, et al. Venoocclusive disease of the liver following bone marrow transplantation. Transplantation. 1987;44:778–783
  6. Bearman SI. The syndrome of hepatic veno-occlusive disease after marrow transplantation. Blood. 1995;85:3005–3020
  7. Hogan WJ, Maris M, Storer B, et al. Hepatic injury after nonmyeloablative conditioning followed by allogeneic hematopoietic cell transplantation: a study of 193 patients. Blood. 2004;103:78–84
  8. Schetelig J, Kroger N, Held TK, et al. Allogeneic transplantation after reduced conditioning in high risk patients is complicated by a high incidence of acute and chronic graft-versus-host disease. Haematologica. 2002;87:299–305
  9. Shapira MY, Resnick IB, Bitan M, et al. Low transplant-related mortality with allogeneic stem cell transplantation in elderly patients. Bone Marrow Transplant. 2004;34:155–159
  10. McSweeney PA, Niederwieser D, Shizuru JA, et al. Hematopoietic cell transplantation in older patients with hematologic malignancies: replacing high-dose cytotoxic therapy with graft-versus-tumor effects. Blood. 2001;97:3390–3400
  11. Mielcarek M, Martin PJ, Leisenring W, et al. Graft-versus-host disease after nonmyeloablative versus conventional hematopoietic stem cell transplantation. Blood. 2003;102:756–762
  12. Junghanss C, Marr KA, Carter RA, et al. Incidence and outcome of bacterial and fungal infections following nonmyeloablative compared with myeloablative allogeneic hematopoietic stem cell transplantation: a matched control study. Biol Blood Marrow Transplant. 2002;8:512–520
  13. Junghanss C, Boeckh M, Carter RA, et al. Incidence and outcome of cytomegalovirus infections following nonmyeloablative compared with myeloablative allogeneic stem cell transplantation, a matched control study. Blood. 2002;99:1978–1985
  14. Laughlin MJ, Eapen M, Rubinstein P, et al. Outcomes after transplantation of cord blood or bone marrow from unrelated donors in adults with leukemia. N Engl J Med. 2004;351:2265–2275
  15. Rocha V, Labopin M, Sanz G, et al. Transplants of umbilical-cord blood or bone marrow from unrelated donors in adults with acute leukemia. N Engl J Med. 2004;351:2276–2285
  16. Takahashi S, Iseki T, Ooi J, et al. Single-institute comparative analysis of unrelated bone marrow transplantation and cord blood transplantation for adult patients with hematologic malignancies. Blood. 2004;104:3813–3820
  17. Tomonari A, Iseki T, Takahashi S, et al. Varicella-zoster virus infection in adult patients after unrelated cord blood transplantation: a single institute experience in Japan. Br J Haematol. 2003;122:802–805
  18. Tomonari A, Iseki T, Ooi J, et al. Cytomegalovirus infection following unrelated cord blood transplantation for adult patients: a single institute experience in Japan. Br J Haematol. 2003;121:304–311
  19. Maeda T, Kusumi E, Kami M, et al. Disseminated tuberculosis following reduced-intensity cord blood transplantation for adult patients with hematological diseases. Bone Marrow Transplant. 2005;35:91–97
  20. Hamza NS, Lisgaris M, Yadavalli G, et al. Kinetics of myeloid and lymphocyte recovery and infectious complications after unrelated umbilical cord blood versus HLA-matched unrelated donor allogeneic transplantation in adults. Br J Haematol. 2004;124:488–498
  21. Kishi Y, Miyakoshi S, Kami M, et al. Early central nervous system complications after reduced-intensity stem cell transplantation. Biol Blood Marrow Transplant. 2004;10:561–568
  22. Kishi Y, Kami M, Miyakoshi S, et al. Early immune reaction after reduced-intensity cord-blood transplantation for adult patients. Transplantation. 2005;80:34–40
  23. Narimatsu H, Matsumura T, Kami M, et al. Bloodstream infection after umbilical cord blood transplantation using reduced-intensity stem cell transplantation for adult patients. Biol Blood Marrow Transplant. 2005;11:429–436
  24. Nishihira H, Kato K, Isoyama K, et al. The Japanese cord blood bank network experience with cord blood transplantation from unrelated donors for haematological malignancies: an evaluation of graft-versus-host disease prophylaxis. Br J Haematol. 2003;120:516–522
  25. Nash RA, Antin JH, Karanes C, et al. Phase 3 study comparing methotrexate and tacrolimus with methotrexate and cyclosporine for prophylaxis of acute graft-versus-host disease after marrow transplantation from unrelated donors. Blood. 2000;96:2062–2068
  26. Yee GC, Self SG, McGuire TR, et al. Serum cyclosporine concentration and risk of acute graft-versus-host disease after allogeneic marrow transplantation. N Engl J Med. 1988;319:65–70
  27. Hiraoka A, Ohashi Y, Okamoto S, et al. Phase III study comparing tacrolimus (FK506) with cyclosporine for graft-versus-host disease prophylaxis after allogeneic bone marrow transplantation. Bone Marrow Transplant. 2001;28:181–185
  28. Ratanatharathorn V, Nash RA, Przepiorka D, et al. Phase III study comparing methotrexate and tacrolimus (prograf, FK506) with methotrexate and cyclosporine for graft-versus-host disease prophylaxis after HLA-identical sibling bone marrow transplantation. Blood. 1998;92:2303–2314
  29. Przepiorka D, Weisdorf D, Martin P, et al. 1994 Consensus conference on acute GVHD grading. Bone Marrow Transplant. 1995;15:825–828
  30. Hughes WT, Armstrong D, Bodey GP, et al. 2002 guidelines for the use of antimicrobial agents in neutropenic patients with cancer. Clin Infect Dis. 2002;34:730–751
  31. Gooley TA, Leisenring W, Crowley J, Storer BE. Estimation of failure probabilities in the presence of competing risks: new representations of old estimators. Stat Med. 1999;18:695–706
  32. Sakiyama M, Kami M, Hori A, et al. Regimen-related toxicity following reduced-intensity stem-cell transplantation (RIST): comparison between Seattle criteria and National Cancer Center Common Toxicity Criteria (NCI-CTC) version 2.0. Bone Marrow Transplant. 2004;34:787–794
  33. Iwata H, Kami M, Hori A, et al. An autopsy-based retrospective study of secondary thrombotic thrombocytopenic purpura. Haematologica. 2001;86:669–670
  34. Bennett WM, Pulliam JP. Cyclosporine nephrotoxicity. Ann Intern Med. 1983;99:851–854
  35. Arcese W, Rocha V, Labopin M, et al. Unrelated cord blood transplants in adults with hematologic malignancies. Haematologica. 2006;91:223–230
  36. Chao NJ, Koh LP, Long GD, et al. Adult recipients of umbilical cord blood transplants after nonmyeloablative preparative regimens. Biol Blood Marrow Transplant. 2004;10:569–575
  37. Barker JN, Weisdorf DJ, DeFor TE, et al. Transplantation of 2 partially HLA-matched umbilical cord blood units to enhance engraftment in adults with hematologic malignancy. Blood. 2005;105:1343–1347
  38. Barker JN, Weisdorf DJ, DeFor TE, et al. Rapid and complete donor chimerism in adult recipients of unrelated donor umbilical cord blood transplantation after reduced-intensity conditioning. Blood. 2003;102:1915–1919

PII: S1083-8791(06)00518-0

doi: 10.1016/j.bbmt.2006.07.013

Biology of Blood and Marrow Transplantation
Volume 12, Issue 12 , Pages 1302-1309 , December 2006

Article Tools

* Image Usage & Resolution