Biology of Blood and Marrow Transplantation
Volume 12, Issue 12 , Pages 1335-1342 , December 2006

Antigen-Specific T-Lymphocyte Function After Cord Blood Transplantation

  • Geoff Cohen

      Affiliations

    • The EMMES Corporation, Rockville, Maryland
    • ,
  • Shelly L. Carter

      Affiliations

    • The EMMES Corporation, Rockville, Maryland
    • ,
  • Kenneth I. Weinberg

      Affiliations

    • Department of Pediatrics, Childrens Hospital Los Angeles, Los Angeles, California
    • ,
  • Bernadette Masinsin

      Affiliations

    • Department of Pediatrics, Childrens Hospital Los Angeles, Los Angeles, California
    • ,
  • Eva Guinan

      Affiliations

    • Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts
    • ,
  • Joanne Kurtzberg

      Affiliations

    • Department of Pediatrics, Duke University Medical Center, Durham, North Carolina
    • ,
  • John E. Wagner

      Affiliations

    • Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota
    • ,
  • Nancy A. Kernan

      Affiliations

    • Department of Pediatrics, Memorial Sloan-Kettering Cancer Center, New York, New York
    • ,
  • Robertson Parkman

      Affiliations

    • Department of Pediatrics, Childrens Hospital Los Angeles, Los Angeles, California
    • Corresponding Author InformationCorrespondence and reprint requests: Robertson Parkman, MD, Division of Research Immunology/Bone Marrow Transplantation, Childrens Hospital Los Angeles, The Saban Research Institute, 4650 Sunset Boulevard, Mail Stop 62, Los Angeles, CA 90027.

Received 21 June 2006 ,Accepted 18 August 2006.

  • Image Result

    Time from transplantation to first positive antigen response for 31 patients with no recorded clinical viral infections and 35 patients with viral infections. No significant difference is seen between

    Time from transplantation to first positive antigen response for 31 patients with no recorded clinical viral infections and 35 patients with viral infections. No significant difference is seen between the 2 samples (P = .14; Wilcoxon’s test).

  • Image Result
    Impact of posttransplantation viral infection on the development of anti-herpes T-lymphocyte responses. Results are the first positive response to the individual virus or the last negative response: (

    Impact of posttransplantation viral infection on the development of anti-herpes T-lymphocyte responses. Results are the first positive response to the individual virus or the last negative response: (A) HSV; (B) CMV; (C) VZV. A Δ CPM > 3000 was considered positive.

  • Image Result
    Cumulative incidence of antigen-specific T-lymphocyte proliferation in UCBT recipients who were serologically positive and negative before transplantation. Results are censored at the last negative ev

    Cumulative incidence of antigen-specific T-lymphocyte proliferation in UCBT recipients who were serologically positive and negative before transplantation. Results are censored at the last negative evaluation. Log-rank test P values: (A) HSV, .59); (B) CMV, .86; (C) VZV, .81.

  • Image Result
    Absolute lymphocyte counts of recipients who did and did not develop antigen-specific T- lymphocyte responses to 1 or more herpes viral antigens: (A) CD3; (B) CD4; (C) CD8; (D) CD19.

    Absolute lymphocyte counts of recipients who did and did not develop antigen-specific T- lymphocyte responses to 1 or more herpes viral antigens: (A) CD3; (B) CD4; (C) CD8; (D) CD19.

PII: S1083-8791(06)00578-7

doi: 10.1016/j.bbmt.2006.08.036

Biology of Blood and Marrow Transplantation
Volume 12, Issue 12 , Pages 1335-1342 , December 2006

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