Biology of Blood and Marrow Transplantation
Volume 12, Issue 12 , Pages 1335-1342 , December 2006

Antigen-Specific T-Lymphocyte Function After Cord Blood Transplantation

  • Geoff Cohen

      Affiliations

    • The EMMES Corporation, Rockville, Maryland
  • ,
  • Shelly L. Carter

      Affiliations

    • The EMMES Corporation, Rockville, Maryland
  • ,
  • Kenneth I. Weinberg

      Affiliations

    • Department of Pediatrics, Childrens Hospital Los Angeles, Los Angeles, California
  • ,
  • Bernadette Masinsin

      Affiliations

    • Department of Pediatrics, Childrens Hospital Los Angeles, Los Angeles, California
  • ,
  • Eva Guinan

      Affiliations

    • Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts
  • ,
  • Joanne Kurtzberg

      Affiliations

    • Department of Pediatrics, Duke University Medical Center, Durham, North Carolina
  • ,
  • John E. Wagner

      Affiliations

    • Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota
  • ,
  • Nancy A. Kernan

      Affiliations

    • Department of Pediatrics, Memorial Sloan-Kettering Cancer Center, New York, New York
  • ,
  • Robertson Parkman

      Affiliations

    • Department of Pediatrics, Childrens Hospital Los Angeles, Los Angeles, California
    • Corresponding Author InformationCorrespondence and reprint requests: Robertson Parkman, MD, Division of Research Immunology/Bone Marrow Transplantation, Childrens Hospital Los Angeles, The Saban Research Institute, 4650 Sunset Boulevard, Mail Stop 62, Los Angeles, CA 90027.

Received 21 June 2006 ,Accepted 18 August 2006.

References 

  1. Noel DR, Witherspoon RP, Storb R, et al. Does graft-versus-host disease influence the tempo of immunologic recovery after allogeneic human marrow transplantation? (An observation on 56 long-term survivors). Blood. 1978;51:1087–1105
  2. Ochs L, Snu XO, Miller J, et al. Late infections after allogeneic bone marrow transplantations: comparison of incidence in related and unrelated donor transplant recipients. Blood. 1995;86:3979–3986
  3. Parkman R, Weinberg KI. Immunological reconstitution following bone marrow transplantation. Immunol Rev. 1997;157:73–78
  4. Mackall CL, Gress RE. Pathways of T-cell regeneration in mice and humans: implications for bone marrow transplantation and immunotherapy. Immunol Rev. 1997;157:61–72
  5. Storek J, Dawson MA, Maloney DG. Correlation between the numbers of naive T cells infused with blood stem cell allografts and the counts of naive T cells after transplantation. Biol Blood Marrow Transplant. 2003;9:781–784
  6. Petersen JM, Weinberg KI, Annett G, et al. Correlation of antigen-specific T-lymphocyte function by recombinant cytokines in children infected with human immunodeficiency virus type 1. J Pediatr. 1992;121:565–568
  7. Levin MJ, Parkman R, Oxman MN, et al. Proliferative and interferon responses by peripheral blood mononuculear cells after bone marrow transplantation in humans. Infect Immun. 1978;20:678–684
  8. Reusser R, Riddell SR, Meyers JD, et al. Cytotoxic T-lymphocyte response to cytomegalovirus after human allogeneic bone marrow transplantation: pattern of recovery and correlation with cytomegalovirus infection and disease. Blood. 1991;78:1373–1380
  9. Smith RT, Eitzman DV, Catlin ME, et al. The development of the immune response: characterization of the response of the human infant and adult to immunization with salmonella vaccines. Pediatrics. 1964;33:163–183
  10. Fung JC, Tilton RC. TORCH serologies and specific IgM antibody determination in acquired and congenital infections. Ann Clin Lab Sci. 1985;15:204–211
  11. Brustoski K, Moller U, Kramer M, et al. U. IFN-gamma and IL-10 mediate parasite-specific immune responses of cord blood cells induced by pregnancy-associated Plasmodium falciparum malaria. J Immunol. 2005;174:1738–1745
  12. Small TN, Papadopoulos EB, Boulad F, et al. Comparison of immune reconstitution after unrelated and related T-cell–depleted bone marrow transplantation: effect of patient age and donor leukocyte infusions. Blood. 1999;93:467–480
  13. Ottinger HK, Beelen DW, Scheulen B, et al. Improved immune reconstitution after allotransplantation of peripheral blood stem cells instead of bone marrow. Blood. 1996;88:2775–2779
  14. Lenz DC, Kurz SK, Lemmens E, et al. IL-7 regulates basal homeostatic proliferation of antiviral CD4+ T cell memory. Proc Natl Acad Sci USA. 2004;101:9357–9362
  15. Giver CR, Li JM, Hossain MS. Reconstructing immunity after allogeneic transplantation. Immunol Res. 2004;29:269–282
  16. Winston DJ, Huang ES, Miller MJ, et al. Molecular epidemiology of cytomegalovirus infections associated with bone marrow transplantation. Ann Intern Med. 1985;102:16–20
  17. Reichardt VL, Okada CY, Liso A, et al. Idiotype vaccination using dendritic cells after autologous peripheral blood stem cell transplantation for multiple myeloma: a feasibility study. Blood. 1999;93:2411–2419
  18. Guidelines for preventing opportunistic infections among hematopoietic stem cell transplant recipients. MMWR Recomm Rep. 2000;49(RR-10):1-125.
  19. Ljungman P, Reusser P, de la Camara R, et al. Management of CMV infections: recommendations from the infectious diseases working party of the EBMT. Bone Marrow Transplant. 2004;33:1075–1081
  20. Harris DT, Schumacher MJ, Locascio J. Phenotypic and functional immaturity of human umbilical cord blood T lymphocytes. Proc Natl Acad Sci USA. 1992;89:10006–10010
  21. Nonoyama S, Penix LA, Edwards CP, et al. Diminished expression of CD40 ligand by activated neonatal T cells. J Clin Invest. 1995;95:66–75
  22. Parkman R, Cohen G, Carter SL, et al. Successful immune reconstitution decreases leukemic relapse and improves survival in recipients of unrelated cord blood transplantation. Biol Blood Marrow Transplant. 2006;in press

PII: S1083-8791(06)00578-7

doi: 10.1016/j.bbmt.2006.08.036

Biology of Blood and Marrow Transplantation
Volume 12, Issue 12 , Pages 1335-1342 , December 2006