Biology of Blood and Marrow Transplantation
Volume 13, Issue 4 , Pages 463-468 , April 2007

Changes in Serologic Markers of Hepatitis B Following Autologous Hematopoietic Stem Cell Transplantation

  • Ji Eun Uhm

      Affiliations

    • Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    • ,
  • Kihyun Kim

      Affiliations

    • Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    • Corresponding Author InformationCorrespondence and reprint requests: Kihyun Kim, MD, Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University, School of Medicine, 50 Ilwon-dong Gangnam-gu, Seoul 135-710 Korea.
    • ,
  • Tae Kyu Lim

      Affiliations

    • Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    • ,
  • Byeong-Bae Park

      Affiliations

    • Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    • ,
  • Sarah Park

      Affiliations

    • Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    • ,
  • Yong Sang Hong

      Affiliations

    • Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    • ,
  • Sang Cheol Lee

      Affiliations

    • Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    • ,
  • In Gyu Hwang

      Affiliations

    • Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    • ,
  • Kwang Cheol Koh

      Affiliations

    • Division of Gastroenterology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    • ,
  • Mark H. Lee

      Affiliations

    • Division of Hematology-Oncology, Department of Internal Medicine, Konkuk University Hospital, Seoul, Korea
    • ,
  • Jin Seok Ahn

      Affiliations

    • Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    • ,
  • Won Seog Kim

      Affiliations

    • Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    • ,
  • Chul Won Jung

      Affiliations

    • Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    • ,
  • Won Ki Kang

      Affiliations

    • Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea

Received 25 September 2006 ,Accepted 22 November 2006.

References 

  1. Strasser SI, McDonald GB. Hepatitis viruses and hematopoietic cell transplantation: a guide to patient and donor management. Blood. 1999;93:1127–1136
  2. Ohnishi M, Kanda Y, Takeuchi T, et al. Limited efficacy of lamivudine against hepatitis B virus infection in allogeneic hematopoietic stem cell transplant recipients. Transplantation. 2002;73:812–815
  3. Senecal D, Pichon E, Dubois F, Delain M, Linassier C, Colombat P. Acute hepatitis B after autologous stem cell transplantation in a man previously infected by hepatitis B virus. Bone Marrow Transplant. 1999;24:1243–1244
  4. Hui CK, Sun J, Au WY, et al. Occult hepatitis B virus infection in hematopoietic stem cell donors in a hepatitis B virus endemic area. J Hepatol. 2005;42:813–819
  5. Goyama S, Kanda Y, Nannya Y, et al. Reverse seroconversion of hepatitis B virus after hematopoietic stem cell transplantation. Leuk Lymphoma. 2002;43:2159–2163
  6. Ma SY, Lau GK, Cheng VC, Liang R. Hepatitis B reactivation in patients positive for hepatitis B surface antigen undergoing autologous hematopoietic cell transplantation. Leuk Lymphoma. 2003;44:1281–1285
  7. Lee D-H, Kim J-H, Nam J-J, Kim H-R, Shin H-R. Epidemiological findings of hepatitis B infection based on 1998 National Health and Nutrition Survey in Korea. J Korean Med Sci. 2002;17:457–462
  8. Knoll A, Boehm S, Hahn J, Holler E, Jilg W. Reactivation of resolved hepatitis B virus infection after allogeneic haematopoietic stem cell transplantation. Bone Marrow Transplant. 2004;33:925–929
  9. Kempinska A, Kwak EJ, Angel JB. Reactivation of hepatitis B infection following allogeneic bone marrow transplantation in a hepatitis B-immune patient: case report and review of the literature. Clin Infect Dis. 2005;41:1277–1282
  10. Dhedin N, Douvin C, Kuentz M, et al. Reverse seroconversion of hepatitis B after allogeneic bone marrow transplantation: a retrospective study of 37 patients with pretransplant anti-HBs and anti-HBc. Transplantation. 1998;66:616–619
  11. Onozawa M, Hashino S, Izumiyama K, et al. Progressive disappearance of anti-hepatitis B surface antigen antibody and reverse seroconversion after allogeneic hematopoietic stem cell transplantation in patients with previous hepatitis B virus infection. Transplantation. 2005;79:616–619
  12. Niesters HG, Krajden M, Cork L, et al. A multicenter study evaluation of the Digene Hybrid Capture II signal amplification technique for detection of hepatitis B virus DNA in serum samples and testing of EUROHEP standards. J Clin Microbiol. 2000;38:2150–2155
  13. Hsiao LT, Chiou TJ, Liu JH, et al. Extended lamivudine therapy against hepatitis B virus infection in hematopoietic stem cell transplant recipients. Biol Blood Marrow Transplant. 2006;12:84–94
  14. Chen PM, Liu JH, Fan FS, et al. Liver disease after bone marrow transplantation—the Taiwan experience. Transplantation. 1995;59:1139–1143
  15. Lau GK, Leung YH, Fong DY, et al. High hepatitis B virus (HBV) DNA viral load as the most important risk factor for HBV reactivation in patients positive for HBV surface antigen undergoing autologous hematopoietic cell transplantation. Blood. 2002;99:2324–2330
  16. Lai CL, Chien RN, Leung NW, et al. Asia Hepatitis Lamivudine Study Group A one-year trial of lamivudine for chronic hepatitis B. N Engl J Med. 1998;339:61–68
  17. Hussain M, Lok AS. Mutations in the hepatitis B virus polymerase gene associated with antiviral treatment for hepatitis B. J Viral Hepat. 1999;6:183–194
  18. Leung N. Nucleoside analogues in the treatment of chronic hepatitis B. J Gastroenterol Hepatol. 2000;15(suppl):E53–E60
  19. Liaw YF, Leung NW, Chang TT, et al. Asia Hepatitis Lamivudine Study Group Effects of extended lamivudine therapy in Asian patients with chronic hepatitis B. Gastroenterology. 2000;119:172–180
  20. Silvestri F, Sperotto A, Ermacora A, Fanin R, Damiani D, Baccarani M. Lamivudine for the prevention of hepatitis B virus reactivation during autologous stem cell transplantation (A case report). Haematologica. 2000;85:327–329
  21. Uchida N, Gondo H, Himeji D, Kaji Y, Sata M, Niho Y. Lamivudine therapy for a hepatitis B surface antigen (HBsAg)-positive leukemia patient receiving myeloablative chemotherapy and autologous stem cell transplantation. Bone Marrow Transplant. 2000;26:1243–1245
  22. Endo T, Sakai T, Fujimoto K, et al. A possible role for lamivudine as prophylaxis against hepatitis B reactivation in carriers of hepatitis B who undergo chemotherapy and autologous peripheral blood stem cell transplantation for non-Hodgkin’s lymphoma. Bone Marrow Transplant. 2001;27:433–436
  23. Chan TM, Fang GX, Tang CS, Cheng IK, Lai KN, Ho SK. Preemptive lamivudine therapy based on HBV DNA level in HBsAg-positive kidney allograft recipients. Hepatology. 2002;36:1246–1252
  24. Idilman R. Lamivudine prophylaxis in HBV carriers with haemato-oncological malignancies who receive chemotherapy. J Antimicrob Chemother. 2005;55:828–831
  25. Nordbo SA, Skaug K, Holter E, Waage A, Brinch L. Reactivation of hepatitis B virus infection in an anti-HBc and anti-HBs positive patient after allogeneic bone marrow transplantation. Eur J Haematol. 2000;65:86–87
  26. Tur-Kaspa R, Shaul Y, Moore DD, et al. The glucocorticoid receptor recognizes a specific nucleotide sequence in hepatitis B virus DNA causing increased activity of the HBV enhancer. Virology. 1988;167:630–633
  27. van Tol MJ, Gerritsen EJ, de Lange GG, et al. The origin of IgG production and homogeneous IgG components after allogeneic bone marrow transplantation. Blood. 1996;87:818–826

PII: S1083-8791(06)00778-6

doi: 10.1016/j.bbmt.2006.11.019

Biology of Blood and Marrow Transplantation
Volume 13, Issue 4 , Pages 463-468 , April 2007

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