Biology of Blood and Marrow Transplantation
Volume 13, Issue 5 , Pages 608-614 , May 2007

CD34+ Hematopoietic Progenitor Cell Selection of Bone Marrow Grafts for Autologous Transplantation in Pediatric Patients

  • Kimberly A. Kasow

      Affiliations

    • Division of Bone Marrow Transplantation, Therapeutic Production and Quality, St. Jude Children’s Research Hospital, Memphis, Tennessee
    • Corresponding Author InformationCorrespondence and reprint requests: Kimberly A. Kasow, DO, Division of Bone Marrow Transplantation, St. Jude Children’s Research Hospital, 332 N. Lauderdale St., MS 260, Memphis, TN 38105-2794.
    • ,
  • Leigh Sims-Poston

      Affiliations

    • Human Applications Laboratory, Therapeutic Production and Quality, St. Jude Children’s Research Hospital, Memphis, Tennessee
    • ,
  • Paul Eldridge

      Affiliations

    • Human Applications Laboratory, Therapeutic Production and Quality, St. Jude Children’s Research Hospital, Memphis, Tennessee
    • ,
  • Gregory A. Hale

      Affiliations

    • Division of Bone Marrow Transplantation, Therapeutic Production and Quality, St. Jude Children’s Research Hospital, Memphis, Tennessee

Received 10 November 2006 ,Accepted 11 January 2007.

References 

  1. Civin CI, Trischmann T, Kadan NS, et al. Highly purified CD34-positive cells reconstitute hematopoiesis. J Clin Oncol. 1996;14:2224–2233
  2. Vogel W, Schedings S, Kanz L, Brugger W. Clinical applications of CD34(+) peripheral blood progenitor cells (PBPC). Stem Cells. 2000;18:87–92
  3. Chou T, Sano M, Ogura M, et al. Isolation and transplantation of highly purified autologous peripheral CD34+progenitor cells: purging efficacy, hematopoietic reconstitution following high dose chemotherapy in patients with breast cancer: results of a feasibility study in Japan. Breast Cancer. 2005;12:178–188
  4. Kruger W, Gruber M, Hennings S, et al. Purging and haematopoietic progenitor cell selection by CD34+ cell separation. Bone Marrow Transplant. 1998;21:665–671
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  9. Prince HM, Bashford J, Wall D, et al. Isolex 300i CD34-selected cells to support multiple cycles of high-dose therapy. Cytotherapy. 2002;4:137–145
  10. Preti RA, Lazarus HM, Winter J, et al. Tumor cell depletion of peripheral blood progenitor cells using positive and positive/negative selection in metastatic breast cancer. Cytotherapy. 2001;3:85–95
  11. Handgretinger R, Lang P, Schumm M, et al. Isolation and transplantation of autologous peripheral CD34+ progenitor cells highly purified by magnetic-activated cell sorting. Bone Marrow Transplant. 1998;21:987–993
  12. Kajiume T, Kawano Y, Takaue Y, et al. New consecutive high-dose chemotherapy modality with fractionated blood stem cell support in the treatment of high-risk pediatric solid tumors: a feasibility study. Bone Marrow Transplant. 1998;21:147–151
  13. Hale G, Bowman L, Stewart C, et al. Cyclophosphamide and targeted dose topotecan with autologous hematopoietic stem cell rescue for solid tumors. Proc Am Soc Clin Oncol. 2004;23:803a
  14. Hale GA, Horwitz E, Leung W, et al. CD133+ Hematopoietic cells successfully reconstitute hematopoiesis following autologous peripheral blood stem cell transplantation. Blood. 2004;104:130a
  15. National Cancer Institute. Common toxicity criteria, version 2.0 (CTC). 1999;Bethesda, MD
  16. O’Donnell PV, Myers B, Edwards J, et al. CD 34 selection using three immunoselection devices: comparison of T-cell depleted allografts. Cytotherapy. 2001;3:483–488
  17. Watts MJ, Somervaille TC, Ings SJ, et al. Variable product purity and functional capacity after CD34 selection: a direct comparison of the CliniMACS (v2.1) and Isolex 300i (v2.5) clinical scale devices. Br J Haematol. 2002;118:117–123
  18. Vose JM, Sharp G, Chan WC, et al. Autologous transplantation for aggressive non-Hodgkin’s lymphoma: results of a randomized trial evaluating graft source and minimal residual disease. J Clin Oncol. 2002;20:2344–2352
  19. Vicent MG, Madero L, Chamorro l, et al. Comparative cost analysis of autologous peripheral blood progenitor cell and bone marrow transplantation in pediatric patients with malignancies. Haematologica. 2001;86:1087–1094
  20. Imai Y, Chou T, Tobinai K, et al. Isolation and transplantation of highly purified autologous peripheral CD34+ progenitor cells: purging efficacy, hematopoietic reconstitution in non-Hodgkin’s lymphoma (NHL): result of Japanese phase II study. Bone Marrow Transplant. 2005;35:479–487
  21. Gryn J, Shadduck RK, Lister J, et al. Factors affecting purification of CD34+ peripheral blood stem cells using the Baxter Isolex 300i. J Hematother Stem Cell Res. 2002;11:719–730
  22. Humpe A, Riggert J, Wolf C, et al. Successful transplantation and engraftment of peripheral blood stem cells after cryopreservation, positive and negative purging procedures, and a second cryopreservation cycle. Ann Hematol. 2001;80:109–112
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 This work was supported in part by grants P30 CA-21765, and the American Lebanese Syrian Associated Charities (ALSAC).

PII: S1083-8791(07)00117-6

doi: 10.1016/j.bbmt.2007.01.074

Biology of Blood and Marrow Transplantation
Volume 13, Issue 5 , Pages 608-614 , May 2007

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