Biology of Blood and Marrow Transplantation
Volume 13, Issue 6 , Pages 683-690 , June 2007

Bisphosphonate Therapy for Reduced Bone Mineral Density in Children with Chronic Graft-versus-Host Disease

  • Paul A. Carpenter

      Affiliations

    • Fred Hutchinson CRC, Seattle, Washington
    • University of Washington, Seattle, Washington
    • Corresponding Author InformationCorrespondence and reprint requests: Paul A. Carpenter, MD, Fred Hutchinson CRC, Clinical Research Division, 1100 Fairview Avenue North, Mailstop D5-290, Seattle, WA 98109.
    • ,
  • Paul Hoffmeister

      Affiliations

    • Fred Hutchinson CRC, Seattle, Washington
    • ,
  • Charles H. Chesnut III

      Affiliations

    • University of Washington, Seattle, Washington
    • ,
  • Barry Storer

      Affiliations

    • Fred Hutchinson CRC, Seattle, Washington
    • University of Washington, Seattle, Washington
    • ,
  • Paula M. Charuhas

      Affiliations

    • Seattle Cancer Care Alliance, Seattle, Washington
    • ,
  • Ann E. Woolfrey

      Affiliations

    • Fred Hutchinson CRC, Seattle, Washington
    • University of Washington, Seattle, Washington
    • ,
  • Jean E. Sanders

      Affiliations

    • Fred Hutchinson CRC, Seattle, Washington
    • University of Washington, Seattle, Washington

Received 21 November 2006 ,Accepted 5 February 2007.

  • Image Result

    Bone mineral density at baseline and after follow-up. Shown for the patients treated without (n = 48) and with (n = 18) bisphosphonates are: (A) the standardized BMD (sBMD) for each patient, together

    Bone mineral density at baseline and after follow-up. Shown for the patients treated without (n = 48) and with (n = 18) bisphosphonates are: (A) the standardized BMD (sBMD) for each patient, together with the median sBMD (filled large squares), at baseline (pre) and at follow-up (post), and (B) the median, 25th, and 75th percentiles (box), and range of the rates of change of sBMD (whiskers).

  • Image Result
    Annualized bone mineral density at baseline and after follow-up. Shown for the patients treated without (n = 48) and with (n = 18) bisphosphonates are: (A) the BMD Z-scores for each patient, together

    Annualized bone mineral density at baseline and after follow-up. Shown for the patients treated without (n = 48) and with (n = 18) bisphosphonates are: (A) the BMD Z-scores for each patient, together with the median Z-score (filled large squares), at baseline (pre) and at follow-up (post), and (B) the median, 25th, and 75th percentiles (box), and range of the rates of change of Z-scores (whiskers).

PII: S1083-8791(07)00146-2

doi: 10.1016/j.bbmt.2007.02.001

Biology of Blood and Marrow Transplantation
Volume 13, Issue 6 , Pages 683-690 , June 2007

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