Biology of Blood and Marrow Transplantation
Volume 13, Issue 7 , Pages 790-805 , July 2007

Impact of Postgrafting Immunosuppressive Regimens on Nonrelapse Mortality and Survival after Nonmyeloablative Allogeneic Hematopoietic Stem Cell Transplant Using the Fludarabine and Low-Dose Total-Body Irradiation 200-cGy

  • Liang-Piu Koh

      Affiliations

    • Bone Marrow Transplant Program, Department of Haematology, Singapore General Hospital, Singapore
    • Stem Cell Transplant Program, Department of Hematology-Oncology, National University Hospital, Singapore
    • Corresponding Author InformationCorrespondence and reprint requests: Liang-Piu Koh, MD, Stem Cell Transplant Program, Department of Hematology-Oncology, National University Hospital, Singapore.
    • ,
  • Chien-Shing Chen

      Affiliations

    • Stem Cell Transplant Program, Department of Hematology-Oncology, National University Hospital, Singapore
    • Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
    • ,
  • Bee-Choo Tai

      Affiliations

    • Centre for Molecular Epidemiology, and Department of Community, Occupation and Family Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
    • ,
  • William Y.K. Hwang

      Affiliations

    • Bone Marrow Transplant Program, Department of Haematology, Singapore General Hospital, Singapore
    • ,
  • Lip-Kun Tan

      Affiliations

    • Stem Cell Transplant Program, Department of Hematology-Oncology, National University Hospital, Singapore
    • ,
  • Hong-Yen Ng

      Affiliations

    • Department of Pharmacy, Singapore General Hospital, Singapore
    • ,
  • Yeh-Ching Linn

      Affiliations

    • Bone Marrow Transplant Program, Department of Haematology, Singapore General Hospital, Singapore
    • ,
  • Mickey B.C. Koh

      Affiliations

    • Bone Marrow Transplant Program, Department of Haematology, Singapore General Hospital, Singapore
    • ,
  • Yeow-Tee Goh

      Affiliations

    • Bone Marrow Transplant Program, Department of Haematology, Singapore General Hospital, Singapore
    • ,
  • Belinda Tan

      Affiliations

    • Stem Cell Transplant Program, Department of Hematology-Oncology, National University Hospital, Singapore
    • ,
  • Shan Lim

      Affiliations

    • Stem Cell Transplant Program, Department of Hematology-Oncology, National University Hospital, Singapore
    • ,
  • Yee-Mei Lee

      Affiliations

    • Stem Cell Transplant Program, Department of Hematology-Oncology, National University Hospital, Singapore
    • ,
  • Kar-Wai Tan

      Affiliations

    • Department of Pharmacy, Singapore General Hospital, Singapore
    • ,
  • Te-Chih Liu

      Affiliations

    • Stem Cell Transplant Program, Department of Hematology-Oncology, National University Hospital, Singapore
    • ,
  • Heng-Joo Ng

      Affiliations

    • Bone Marrow Transplant Program, Department of Haematology, Singapore General Hospital, Singapore
    • ,
  • Yvonne S.M. Loh

      Affiliations

    • Bone Marrow Transplant Program, Department of Haematology, Singapore General Hospital, Singapore
    • ,
  • Benjamin M.F. Mow

      Affiliations

    • Stem Cell Transplant Program, Department of Hematology-Oncology, National University Hospital, Singapore
    • ,
  • Daryl C.L. Tan

      Affiliations

    • Bone Marrow Transplant Program, Department of Haematology, Singapore General Hospital, Singapore
    • ,
  • Patrick H.C. Tan

      Affiliations

    • Haematology and Stem Cell Transplant Center, Mount Elizabeth Hospital, Singapore

Received 5 November 2006 ,Accepted 1 March 2007.

  • Image Result

    A, Cumulative incidence of aGVHD and cGVHD of 67 patients undergoing nonmyeloablative allogeneic transplantation. B, Grade III-IV GVHD. C, Chronic GVHD of 67 patients undergoing nonmyeloablative allog

    A, Cumulative incidence of aGVHD and cGVHD of 67 patients undergoing nonmyeloablative allogeneic transplantation. B, Grade III-IV GVHD. C, Chronic GVHD of 67 patients undergoing nonmyeloablative allogeneic transplantation stratified by postgrafting immunosuppression.

  • Image Result
    A, NRM and B, relapse rate of 67 patients undergoing nonmyelablative allogeneic transplantation stratified by postgrafting immunosuppression.

    A, NRM and B, relapse rate of 67 patients undergoing nonmyelablative allogeneic transplantation stratified by postgrafting immunosuppression.

  • Image Result
    A, OS, current PFS (CPFS), and PFS of 67 patients undergoing nonmyeloablative allogeneic transplantation. B, OS, and C, PFS of 67 patients undergoing nonmyeloablative allogeneic transplantation strati

    A, OS, current PFS (CPFS), and PFS of 67 patients undergoing nonmyeloablative allogeneic transplantation. B, OS, and C, PFS of 67 patients undergoing nonmyeloablative allogeneic transplantation stratified by postgrafting immunosuppression. D, Overall survival. E, current PFS of 67 patients stratified by disease categories and post-grafting immunosuppression. F, OS and PFS of a subgroup of 21 patients with “standard-risk” disease given MTX/MMF/CSP as postgrafting immunousppression.

PII: S1083-8791(07)00194-2

doi: 10.1016/j.bbmt.2007.03.002

Biology of Blood and Marrow Transplantation
Volume 13, Issue 7 , Pages 790-805 , July 2007

Article Tools

* Image Usage & Resolution