Biology of Blood and Marrow Transplantation
Volume 13, Issue 7 , Pages 822-830 , July 2007

Hematopoietic Engraftment in Recipients of Unrelated Donor Umbilical Cord Blood Is Affected by the CD34+ and CD8+ Cell Doses

  • Seitaro Terakura

      Affiliations

    • Department of Hematology and Oncology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    • Tokai Cord Blood Bank, Nagoya, Japan
    • The first two authors contributed equally to this study.
  • ,
  • Eiichi Azuma

      Affiliations

    • Department of Pediatrics and Cell Transplantation, Mie University School of Medicine, Tsu, Japan
    • Tokai Cord Blood Bank, Nagoya, Japan
    • The first two authors contributed equally to this study.
  • ,
  • Makoto Murata

      Affiliations

    • Department of Hematology and Oncology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    • Tokai Cord Blood Bank, Nagoya, Japan
    • Corresponding Author InformationCorrespondence and reprint requests: Makoto Murata, MD, PhD, Department of Hematology and Oncology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, Aichi 466-8550, Japan.
  • ,
  • Tadashi Kumamoto

      Affiliations

    • Department of Pediatrics and Cell Transplantation, Mie University School of Medicine, Tsu, Japan
    • Tokai Cord Blood Bank, Nagoya, Japan
  • ,
  • Masahiro Hirayama

      Affiliations

    • Department of Pediatrics and Cell Transplantation, Mie University School of Medicine, Tsu, Japan
    • Tokai Cord Blood Bank, Nagoya, Japan
  • ,
  • Yoshiko Atsuta

      Affiliations

    • Department of Hematopoietic Stem Cell Transplantation Data Management, Nagoya University School of Medicine, Nagoya, Japan
    • Tokai Cord Blood Bank, Nagoya, Japan
  • ,
  • Yoshihisa Kodera

      Affiliations

    • Bone Marrow Transplantation Center, Japanese Red Cross Nagoya First Hospital, Nagoya, Japan
    • Tokai Cord Blood Bank, Nagoya, Japan
  • ,
  • Makoto Yazaki

      Affiliations

    • Department of Pediatrics, Nagoya Higashi Municipal Hospital, Nagoya, Japan
    • Tokai Cord Blood Bank, Nagoya, Japan
  • ,
  • Tomoki Naoe

      Affiliations

    • Department of Hematology and Oncology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    • Tokai Cord Blood Bank, Nagoya, Japan
  • ,
  • Koji Kato

      Affiliations

    • Department of Pediatric Hematology/Oncology, Japanese Red Cross Nagoya First Hospital, Nagoya, Japan
    • Tokai Cord Blood Bank, Nagoya, Japan

Received 19 December 2006 ,Accepted 12 March 2007.

References 

  1. Kurzberg J, Laughlin M, Graham ML, et al. Placental blood as a source of hematopoietic stem cells for transplantation into unrelated donors. N Engl J Med. 1996;335:157–166
  2. Wagner JE, Rosenthal J, Sweetman R, et al. Successful transplantation of HLA-matched and HLA-mismatched umbilical cord blood from unrelated donors: analysis of engraftment and acute graft-versus-host disease. Blood. 1996;88:795–802
  3. Gluckman E, Rocha V, Boyer-Chammard A, et al. Outcome of cord-blood transplantation from related and unrelated donors: Eurocord Transplant Group and the European Blood and Marrow Transplantation Group. N Engl J Med. 1997;337:373–381
  4. Rubinstein P, Carrier C, Stevens CE, et al. Outcomes among 562 recipients of placental-blood transplants from unrelated donors. N Engl J Med. 1998;339:1565–1577
  5. Laughlin MJ, Eapen M, Rubinstein P, et al. Outcomes after transplantation of cord blood or bone marrow from unrelated donors in adults with leukemia. N Engl J Med. 2004;351:2265–2275
  6. Rocha V, Labopin M, Sanz G, et al. Acute Leukemia Working Party of European Blood and Marrow Transplantation Group Eurocord-Netcord Registry Transplants of umbilical-cord blood or bone marrow from unrelated donors in adults with acute leukemia. N Engl J Med. 2004;351:2276–2285
  7. Takahashi S, Iseki T, Asano S, et al. Single-institute comparative analysis of unrelated bone marrow transplantation and cord blood transplantation for adult patients with hematologic malignancies. Blood. 2004;104:3813–3820
  8. Barker JN, Wagner JE. Umbilical cord blood transplantation: current state of the art. Curr Opin Oncol. 2002;14:160–164
  9. Rocha V, Gluckman E. Clinical use of umbilical cord blood hematopoietic stem cells. Biol Blood Marrow Transplant. 2006;12:34–41
  10. Barker JN, Krepski TP, Weisdorf DJ, et al. Searching for unrelated donor hematopoietic stem cells: availability and speed of umbilical cord blood versus bone marrow. Biol Blood Marrow Transplant. 2002;8:257–260
  11. Laughlin MJ, Barker JN, Bambach B, et al. Hematopoietic engraftment and survival in adult recipients of umbilical-cord blood from unrelated donors. N Engl J Med. 2001;344:1815–1822
  12. Gluckman E, Rocha V, Chevret S, et al. Factors associated with outcomes of unrelated cord blood transplant: guidelines for donor choice. Exp Hematol. 2004;32:397–407
  13. Wagner JE, Barker JN, Davies SM, et al. Transplantation of unrelated donor umbilical cord blood in 102 patients with malignant and nonmalignant diseases: influence of CD34 cell dose and HLA disparity on treatment-related mortality and survival. Blood. 2002;100:1611–1618
  14. Sanz MA, Sanz GF. Unrelated donor umbilical cord blood transplantation in adults. Leukemia. 2002;16:1984–1991
  15. Kernan NA, Flomenberg N, O’Reilly RJ, et al. Graft rejection in recipients of T cell depleted HLA-nonidentical marrow transplants for leukemia: identification of host derived anti-donor allocytotoxic T lymphocytes. Transplantation. 1987;43:482–487
  16. Martin PJ, Hansen JA, Buckner CD, et al. Effect of in vitro depletion of T cells in HLA-identical allogeneic marrow grafts. Blood. 1985;66:664–672
  17. Champlin R, Ho W, Gajewski J, et al. Selective depletion of CD8+ T lymphocytes for prevention of graft-versus-host disease after allogeneic bone marrow transplantation. Blood. 1990;76:418–423
  18. Martin PJ, Rowley SD, Anasetti C, et al. A phase I-II clinical trial to evaluate removal of CD4 cells and partial depletion of CD8 cells from donor marrow for HLA-mismatched unrelated recipients. Blood. 1999;94:2192–2199
  19. Ildstad ST, Wren SM, Bluestone JA, Barbieri SA, Stephany D, Sachs DH. Effect of selective T-cell depletion of host and/or donor bone marrow on lymphopoietic repopulation, tolerance, and graft versus host disease in mixed allogeneic chimeras (B10 + B10.D2 → B10). J Immunol. 1986;136:28–33
  20. Martin PJ. Donor CD8 cells prevent allogeneic marrow graft rejection in mice: potential implications for marrow transplantation in humans. J Exp Med. 1993;178:703–712
  21. Sutherland DR, Anderson L, Chin-Yee I. The ISHAGE guidelines for CD34+ cell determination by flow cytometry: International Society of Hematoherapy and Graft Engineering. J Hematother. 1996;5:213–226
  22. Centers for Disease Control and Prevention. 1997 Revised guidelines for performing CD4+ T-cell determinations in persons infected with human immunodeficiency virus (HIV). MMWR Recomm Rep. 1997;46:1–29
  23. Kobayashi M, Azuma E, Ido M, et al. A pivotal role of Rho GTPase in the regulation of morphology and function of dendritic cells. J Immunol. 2001;167:3585–3591
  24. Przepiorka D, Weisdorf D, Thomas ED, et al. 1994 Consensus conference on acute GVHD grading. Bone Marrow Transplant. 1995;15:825–828
  25. Sullivan KM, Shulman HM, Thomas ED, et al. Chronic graft-versus-host disease in 52 patients: adverse natural course and successful treatment with combination immunosuppression. Blood. 1981;57:267–276
  26. Kaplan EL, Meier P. Nonparametric estimation from incomplete observations. Am Stat Assoc J. 1958;53:457–481
  27. Gooley TA, Leisenring W, Crowley JA, Storer BE. Estimation of failure probability in the presence of competing risks: new representations of old estimators. Stat Med. 1999;18:665–706
  28. Cox DR. Regression models and life-tables. J R Stat Soc B. 1972;34:187–202
  29. Sanz GF, Saavedra S, Planelles D, et al. Standardized, unrelated donor cord blood transplantation in adults with hematologic malignancies. Blood. 2001;98:2332–2338
  30. Martin PJ. Winning the battle of graft versus host. Nat Med. 2000;6:18–19
  31. Martin PJ, Akatsuka Y, Hahne M, Sale G. Involvement of donor T-cell cytotoxic effector mechanisms in preventing allogeneic marrow graft rejection. Blood. 1998;92:2177–2181
  32. Kaufman CL, Colson YL, Wren SM, Watkins S, Simmons RL, Ildstad ST. Phenotypic characterization of a novel bone marrow-derived cell that facilitates engraftment of allogeneic bone marrow stem cells. Blood. 1994;84:2436–2446
  33. Gandy KL, Domen J, Aguila H, Weissman IL. CD8+TCR+ and CD8+TCR-cells in whole bone marrow facilitate the engraftment of hematopoietic stem cells across allogeneic barriers. Immunity. 1999;11:579–590
  34. Miller RG. An immunological suppressor cell inactivating cytotoxic T-lymphocyte precursor cells recognizing it. Nature. 1980;287:544–546
  35. Reich-Zeliger S, Zhao Y, Krauthgamer R, Bachar-Lustig E, Reisner Y. Anti-third party CD8+ CTLs as potent veto cells: coexpression of CD8 and FasL is a prerequisite. Immunity. 2000;13:507–515
  36. Fink PJ, Shimonkevitz RP, Bevan MJ. Veto cells. Annu Rev Immunol. 1988;6:115–137
  37. Bachar-Lustig E, Reich-Zeliger S, Reisner Y. Anti-third-party veto CTLs overcome rejection of hematopoietic allografts: synergism with rapamycin and BM cell dose. Blood. 2003;102:1943–1950
  38. Cohen SB, Perez-Cruz I, Fallen P, Gluckman E, Madrigal JA. Analysis of the cytokine production by cord and adult blood. Hum Immunol. 1999;60:331–336
  39. Narimatsu H, Terakura S, Matsuo K, et al. Short-term methotrexate could reduce early immune reactions and improve outcomes in umbilical cord blood transplantation for adults. Bone Marrow Transplant. 2007;39:31–39
  40. Locatelli F, Rocha V, Reed W, et al. Related umbilical cord blood transplantation in patients with thalassemia and sickle cell disease. Blood. 2003;101:2137–2143
  41. Ruggeri L, Capanni M, Velardi A, et al. Effectiveness of donor natural killer cell alloreactivity in mismatched hematopoietic transplants. Science. 2002;295:2097–2100
  42. Farag SS, Fehniger TA, Caligiuri MA, et al. Natural killer cell receptors: new biology and insights into the graft-versus-leukemia effect. Blood. 2002;100:1935–1947

PII: S1083-8791(07)00215-7

doi: 10.1016/j.bbmt.2007.03.006

Biology of Blood and Marrow Transplantation
Volume 13, Issue 7 , Pages 822-830 , July 2007