Biology of Blood and Marrow Transplantation
Volume 13, Issue 7 , Pages 831-837 , July 2007

Diagnostic Yield of Bronchoalveolar Lavage Is Low in Allogeneic Hematopoietic Stem Cell Recipients Receiving Immunosuppressive Therapy or with Acute Graft-versus-Host Disease: The St. Jude Experience, 1990-2002

  • Kimberly A. Kasow

      Affiliations

    • Division of Bone Marrow Transplantation, St. Jude Children’s Research Hospital, Memphis, Tennessee
    • Corresponding Author InformationCorrespondence and reprint requests: Kimberly A. Kasow, DO, Division of Bone Marrow Transplantation, St. Jude Children’s Research Hospital, 332 North Lauderdale, MS 260, Memphis, TN 38105.
    • ,
  • Erin King

      Affiliations

    • Chicago College of Osteopathic Medicine, Downers Grove, Illinois
    • ,
  • Richard Rochester

      Affiliations

    • Division of Bone Marrow Transplantation, St. Jude Children’s Research Hospital, Memphis, Tennessee
    • ,
  • Xin Tong

      Affiliations

    • Department of Biostatistics, St. Jude Children’s Research Hospital, Memphis, Tennessee
    • ,
  • Deo Kumar Srivastava

      Affiliations

    • Department of Biostatistics, St. Jude Children’s Research Hospital, Memphis, Tennessee
    • ,
  • Edwin M. Horwitz

      Affiliations

    • Division of Bone Marrow Transplantation, St. Jude Children’s Research Hospital, Memphis, Tennessee
    • ,
  • Wing Leung

      Affiliations

    • Division of Bone Marrow Transplantation, St. Jude Children’s Research Hospital, Memphis, Tennessee
    • ,
  • Paul Woodard

      Affiliations

    • Division of Bone Marrow Transplantation, St. Jude Children’s Research Hospital, Memphis, Tennessee
    • ,
  • Rupert Handgretinger

      Affiliations

    • Division of Bone Marrow Transplantation, St. Jude Children’s Research Hospital, Memphis, Tennessee
    • ,
  • Gregory A. Hale

      Affiliations

    • Division of Bone Marrow Transplantation, St. Jude Children’s Research Hospital, Memphis, Tennessee

Received 12 September 2006 ,Accepted 16 March 2007.

References 

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  2. Meyers S, Reinhard H, Gottschling S, et al. Pulmonary dysfunction in pediatric oncology patients. Pediatr Hematol Oncol. 2004;21:175–195
  3. Hongeng S, Krance RA, Bowman LC, et al. Outcomes of transplantation with matched-sibling and unrelated-donor bone marrow in children with leukaemia. Lancet. 1997;350:767–771
  4. Hale G, Bowman L, Stewart C, et al. Cyclophosphamide and targeted dose topotecan with autologous hematopoietic stem cell rescue for solid tumors. Proc Am Soc Clin Oncol. 2004;23:803a;(Abstract #8534)
  5. Strother D, Ashley D, Kellie SJ, et al. Feasibility of four consecutive high-dose chemotherapy cycles with stem-cell rescue for patients with newly diagnosed medulloblastoma or supratentorial primitive neuroectodermal tumor after craniospinal radiotherapy: results of a collaborative study. J Clin Oncol. 2001;19:2696–2704
  6. Bisop MR, Henslee-Downey PJ, Anderson JR, et al. Long-term survival in advanced chronic myelogenous leukemia following bone marrow transplantation from haploidentical related donors. Bone Marrow Transplant. 1996;18:747–753
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  8. Boersma WG, Erjavec Z, van der Werf TS, et al. Bronchoscopic diagnosis of pulmonary infiltrates in granulocytopenic patients with hematologic malignancies: BAL versus PSB and PBAL. Respir Med. 2007;101:317–325
  9. Joos L, Chhajed PN, Wallner J, et al. Pulmonary infections diagnosed by BAL: a 12-year experience in 1066 immunocompromised patients. Respir Med. 2007;101:93–97
  10. Eikenberry M, Bartakova H, Defor T, et al. Natural history of pulmonary complications in children after bone marrow transplantation. Biol Blood Marrow Transplant. 2005;11:56–64
  11. Patel NR, Lee PS, Kim JH, et al. The influence of diagnostic bronchoscopy on clinical outcomes comparing adult autologous and allogeneic bone marrow transplant patients. Chest. 2005;127:1388–1396
  12. Rano A, Agusti C, Jimenez P, et al. Pulmonary infiltrates in non-HIV immunocompromised patients: a diagnostic approach using non-invasive and bronchoscopic procedures. Thorax. 2001;56:379–387
  13. Robbins RA, Linder J, Stahl MG, et al. Diffuse alveolar hemorrhage in autologous bone marrow transplant recipients. Am J Med. 1989;87:511–518
  14. Lewis ID, Defor T, Weisdorf DJ. Increasing incidence of diffuse alveolar hemorrhage following allogeneic bone marrow transplantation: cryptic etiology and uncertain therapy. Bone Marrow Transplant. 2000;26:539–543
  15. Pastores SM, Papadopoulos E, Voigt L, Halpern NA. Diffuse alveolar hemorrhage after allogeneic hematopoietic stem-cell transplantation: treatment with recombinant factor VIIa. Chest. 2003;124:2400–2403
  16. Latini P, Aristei C, Aversa F, et al. Lung damage following bone marrow transplantation after hyperfractionated total body irradiation. Radiother Oncol. 1991;22:127–132
  17. Limper AH. Chemotherapy-induced lung disease. Clin Chest Med. 2004;25:53–64

PII: S1083-8791(07)00220-0

doi: 10.1016/j.bbmt.2007.03.008

Biology of Blood and Marrow Transplantation
Volume 13, Issue 7 , Pages 831-837 , July 2007

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