Biology of Blood and Marrow Transplantation
Volume 13, Issue 7 , Pages 853-862 , July 2007

Cyclophosphamide following Targeted Oral Busulfan as Conditioning for Hematopoietic Cell Transplantation: Pharmacokinetics, Liver Toxicity, and Mortality

  • Jeannine S. McCune

      Affiliations

    • Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington
    • University of Washington School of Pharmacy, Seattle, Washington
    • Corresponding Author InformationCorrespondence and reprint requests: Jeannine S. McCune, PharmD, Department of Pharmacy, Box 357630, University of Washington, Seattle, WA 98195.
    • ,
  • Ami Batchelder

      Affiliations

    • Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington
    • ,
  • H. Joachim Deeg

      Affiliations

    • Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington
    • University of Washington School of Medicine, Seattle, Washington
    • ,
  • Ted Gooley

      Affiliations

    • Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington
    • ,
  • Scott Cole

      Affiliations

    • Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington
    • ,
  • Brian Phillips

      Affiliations

    • Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington
    • ,
  • H. Gary Schoch

      Affiliations

    • Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington
    • ,
  • George B. McDonald

      Affiliations

    • Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington
    • University of Washington School of Medicine, Seattle, Washington

Received 25 January 2007 ,Accepted 29 March 2007.

  • Image Result

    Comparison of CY, HCY, and CEPM exposure by conditioning regimen. The AUC0-48hr in patients receiving CY/TBI (gray shading) and TBU/CY (no shading). Box designates 25th, 50th, and 75th percentile. Whi

    Comparison of CY, HCY, and CEPM exposure by conditioning regimen. The AUC0-48hr in patients receiving CY/TBI (gray shading) and TBU/CY (no shading). Box designates 25th, 50th, and 75th percentile. Whiskers designate the extremes with one AUCCEPM of 1881 μM·h in the CY/TBI (gray shading) being excluded for easier presentation.

  • Image Result
    Relationship between AUC of CY and its metabolites in patients receiving preparative regimens of TBU/CY and CY/TBI. Top panel, AUCCY (x-axis) versus AUCHCY (y-axis); bottom panel, AUCCY (x-axis) versu

    Relationship between AUC of CY and its metabolites in patients receiving preparative regimens of TBU/CY and CY/TBI. Top panel, AUCCY (x-axis) versus AUCHCY (y-axis); bottom panel, AUCCY (x-axis) versus AUCCEPM (y-axis).

PII: S1083-8791(07)00236-4

doi: 10.1016/j.bbmt.2007.03.012

Biology of Blood and Marrow Transplantation
Volume 13, Issue 7 , Pages 853-862 , July 2007

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