Biology of Blood and Marrow Transplantation
Volume 13, Issue 7 , Pages 872-874 , July 2007

Treatment of Severe Hemorrhagic Cystitis after Allogeneic Stem Cell Transplantation with Palifermin, a Recombinant Human Keratinocyte Growth Factor

  • Akos Czibere

      Affiliations

    • Department of Hematology, Oncology and Clinical Immunology, Heinrich Heine-University, Düsseldorf, 40225 Duesseldorf, Germany
    • ,
  • Ingmar Bruns

      Affiliations

    • Department of Hematology, Oncology and Clinical Immunology, Heinrich Heine-University, Düsseldorf, 40225 Duesseldorf, Germany
    • ,
  • Thorsten Graef

      Affiliations

    • Department of Hematology, Oncology and Clinical Immunology, Heinrich Heine-University, Düsseldorf, 40225 Duesseldorf, Germany
    • ,
  • Roland Fenk

      Affiliations

    • Department of Hematology, Oncology and Clinical Immunology, Heinrich Heine-University, Düsseldorf, 40225 Duesseldorf, Germany
    • ,
  • Fabian Zohren

      Affiliations

    • Department of Hematology, Oncology and Clinical Immunology, Heinrich Heine-University, Düsseldorf, 40225 Duesseldorf, Germany
    • ,
  • Nancy Safaian

      Affiliations

    • Department of Hematology, Oncology and Clinical Immunology, Heinrich Heine-University, Düsseldorf, 40225 Duesseldorf, Germany
    • ,
  • Mirko Mueller

      Affiliations

    • Department of Urology, Heinrich Heine-University, Düsseldorf, 40225 Duesseldorf, Germany
    • ,
  • Rainer Haas

      Affiliations

    • Department of Hematology, Oncology and Clinical Immunology, Heinrich Heine-University, Düsseldorf, 40225 Duesseldorf, Germany
    • ,
  • Guido Kobbe

      Affiliations

    • Department of Hematology, Oncology and Clinical Immunology, Heinrich Heine-University, Düsseldorf, 40225 Duesseldorf, Germany

References 

  1. Nevo S, Swan V, Enger C, et al. Acute bleeding after bone marrow transplantation (BMT)—incidence and effect on survival (A quantitative analysis in 1,402 patients). Blood. 1998;91:1469–1477
  2. El-Zimaity M, Saliba R, Chan K, et al. Hemorrhagic cystitis after allogeneic hematopoietic stem cell transplantation: donor type matters. Blood. 2004;103:4674–4680
  3. deVries CR, Freiha FS. Hemorrhagic cystitis: a review. J Urol. 1990;143:1–9
  4. Tsuboi K, Kishi K, Ohmachi K, et al. Multivariate analysis of risk factors for hemorrhagic cystitis after hematopoietic stem cell transplantation. Bone Marrow Transplant. 2003;32:903–907
  5. Finch PW, Rubin JS, Miki T, Ron D, Aaronson SA. Human KGF is FGF-related with properties of a paracrine effector of epithelial cell growth. Science. 1989;245:752–755
  6. Gorczynska E, Turkiewicz D, Rybka K, et al. Incidence, clinical outcome, and management of virus-induced hemorrhagic cystitis in children and adolescents after allogeneic hematopoietic cell transplantation. Biol Blood Marrow Transplant. 2005;11:797–804
  7. Priftakis P, Bogdanovic G, Kokhaei P, Mellstedt H, Dalianis T. BK virus (BKV) quantification in urine samples of bone marrow transplanted patients is helpful for diagnosis of hemorrhagic cystitis, although wide individual variations exist. J Clin Virol. 2003;26:71–77
  8. Sencer SF, Haake RJ, Weisdorf DJ. Hemorrhagic cystitis after bone marrow transplantation (Risk factors and complications). Transplantation. 1993;56:875–879
  9. Garderet L, Bittencourt H, Sebe P, et al. Cystectomy for severe hemorrhagic cystitis in allogeneic stem cell transplant recipients. Transplantation. 2000;70:1807–1811
  10. Ulich TR, Whitcomb L, Tang W, et al. Keratinocyte growth factor ameliorates cyclophosphamide-induced ulcerative hemorrhagic cystitis. Cancer Res. 1997;57:472–475

PII: S1083-8791(07)00238-8

doi: 10.1016/j.bbmt.2007.04.002

Biology of Blood and Marrow Transplantation
Volume 13, Issue 7 , Pages 872-874 , July 2007

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