Biology of Blood and Marrow Transplantation
Volume 13, Issue 8 , Pages 886-888 , August 2007

Hematopoietic Cell Transplantation Directly into Dystrophic Muscle Fails to Reconstitute Satellite Cells and Myofibers

  • Christian S. Kuhr

      Affiliations

    • Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington
    • Department of Surgery, University of Washington School of Medicine, Seattle, Washington
    • Department of Urology, University of Washington School of Medicine, Seattle, Washington
    • C. S. Kuhr and M. Lupu contributed equally to this work.
    • Corresponding Author InformationCorrespondence and reprint requests: Christian S. Kuhr, MD, Virginia Mason Medical Center, C7-URO, 1100 Ninth Ave, Seattle, WA 98101.
    • ,
  • Marilena Lupu

      Affiliations

    • Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington
    • C. S. Kuhr and M. Lupu contributed equally to this work.
    • ,
  • Rainer Storb

      Affiliations

    • Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington
    • Department of Medicine, University of Washington School of Medicine, Seattle, Washington

Received 15 January 2007 ,Accepted 27 April 2007.

References 

  1. Ferrari G, Mavilio F. Myogenic stem cells from the bone marrow: a therapeutic alternative for muscular dystrophy?. Neuromuscul Disord. 2002;12(Suppl. 1):S7–S10
  2. Muguruma Y, Reyes M, Nakamura Y, et al. In vivo and in vitro differentiation of myocytes from human bone marrow-derived multipotent progenitor cells. Exp Hematol. 2003;31:1323–1330
  3. Beeres SL, Bax JJ, Kaandorp TA, et al. Usefulness of intramyocardial injection of autologous bone marrow-derived mononuclear cells in patients with severe angina pectoris and stress-induced myocardial ischemia. Am J Cardiol. 2006;97:1326–1331
  4. Meyer GP, Wollert KC, Lotz J, et al. Intracoronary bone marrow cell transfer after myocardial infarction: eighteen months’ follow-up data from the randomized, controlled BOOST (BOne marrOw transfer to enhance ST-elevation infarct regeneration) trial. Circulation. 2006;113:1287–1294
  5. Partridge T. Animal models of muscular dystrophy—what can they teach us?. Neuropathol Appl Neurobiol. 1991;17:353–363
  6. Cooper BJ, Winand NJ, Stedman H, et al. The homologue of the Duchenne locus is defective in X-linked muscular dystrophy of dogs. Nature. 1988;334:154–156
  7. Valentine BA, Cooper BJ, de Lahunta A, O’Quinn R, Blue JT. Canine X-linked muscular dystrophy (An animal model of Duchenne muscular dystrophy: clinical studies). J Neurol Sci. 1988;88:69–81
  8. Valentine BA, Cooper BJ, Cummings JF, deLahunta A. Progressive muscular dystrophy in a golden retriever dog: light microscope and ultrastructural features at 4 and 8 months. Acta Neuropathol. 1986;71:301–310
  9. Hoffman EP, Brown RHJ, Kunkel LM. Dystrophin: the protein product of the Duchenne muscular dystrophy locus. Cell. 1987;51:919–928
  10. Emery AE. The muscular dystrophies. Lancet. 2002;359:687–695
  11. Dell’Agnola C, Wang Z, Storb R, et al. Hematopoietic stem cell transplantation does not restore dystrophin expression in Duchenne muscular dystrophy dogs. Blood. 2004;104:4311–4318
  12. Wagner JL, Burnett RC, DeRose SA, Francisco LV, Storb R, Ostrander EA. Histocompatibility testing of dog families with highly polymorphic microsatellite markers. Transplantation. 1996;62:876–877
  13. Wagner JL, Works JD, Storb R. DLA-DRB1 and DLA-DQB1 histocompatibility typing by PCR-SSCP and sequencing. Tissue Antigens. 1998;52:397–401
  14. Sharp NJ, Kornegay JN, Van Camp SD, et al. An error in dystrophin mRNA processing in golden retriever muscular dystrophy, an animal homologue of Duchenne muscular dystrophy. Genomics. 1992;13:115–121
  15. Yu C, Ostrander E, Bryant E, Burnett R, Storb R. Use of (CA)n polymorphisms to determine the origin of blood cells after allogeneic canine marrow grafting. Transplantation. 1994;58:701–706

PII: S1083-8791(07)00271-6

doi: 10.1016/j.bbmt.2007.04.012

Biology of Blood and Marrow Transplantation
Volume 13, Issue 8 , Pages 886-888 , August 2007

Article Tools

* Image Usage & Resolution