Biology of Blood and Marrow Transplantation
Volume 13, Issue 8 , Pages 877-885 , August 2007

Hematopoietic Stem Cell Transplantation in Multiple Myeloma

  • Shubham Pant

      Affiliations

    • Division of Hematology and Oncology, Ohio State University, Columbus, Ohio
    • ,
  • Edward A. Copelan

      Affiliations

    • Department of Hematologic Oncology and Blood Disorders, Taussig Cancer Center, Cleveland Clinic Foundation
    • Corresponding Author InformationCorrespondence and reprint requests: Edward A. Copelan, MD, Department of Hematologic Oncology and Blood Disorders, Taussig Cancer Center, Cleveland Clinic Foundation, 9500 Euclid Avenue R35, Cleveland, Ohio 44195.

Received 27 February 2007 ,Accepted 1 May 2007.

  • Image Result

    Theory of autologous followed by nonablative allogeneic transplantation. A recipient with multiple myeloma has normal (RN) and multiple myeloma (RM) and myeloma stem cells (RMSC) in the marrow prior t

    Theory of autologous followed by nonablative allogeneic transplantation. A recipient with multiple myeloma has normal (RN) and multiple myeloma (RM) and myeloma stem cells (RMSC) in the marrow prior to autologous transplantation. Following high-dose therapy and autotransplantation, the number of malignant cells is reduced. Allogeneic hematopoietic stem cell transplantation following nonablative preparation permits engraftment of normal donor hematopoietic cells (DN). Immunologic eradication of recipient normal and malignant cells results in complete donor hematopoietic chimerism.

PII: S1083-8791(07)00273-X

doi: 10.1016/j.bbmt.2007.05.002

Biology of Blood and Marrow Transplantation
Volume 13, Issue 8 , Pages 877-885 , August 2007

Article Tools

* Image Usage & Resolution