Biology of Blood and Marrow Transplantation
Volume 13, Issue 10 , Pages 1224-1232 , October 2007

Positive Selection and Transplantation of Autologous Highly Purified CD133+ Stem Cells in Resistant/Relapsed Chronic Lymphocytic Leukemia Patients Results in Rapid Hematopoietic Reconstitution without an Adequate Leukemic Cell Purging

  • Alessandro Isidori

      Affiliations

    • Institute of Hematology and Medical Oncology, “L. & A. Seràgnoli,” University of Bologna, Bologna, Italy
    • Hematology and Bone Marrow Transplant Center, San Salvatore Hospital, Pesaro, Italy
    • Corresponding Author InformationCorrespondence and reprint requests: Alessandro Isidori, MD, Hematology and Bone Marrow Transplant Center, San Salvatore Hospital, Via Lombroso, 61100 Pesaro, Italy.
    • ,
  • Maria Rosa Motta

      Affiliations

    • Institute of Hematology and Medical Oncology, “L. & A. Seràgnoli,” University of Bologna, Bologna, Italy
    • ,
  • Monica Tani

      Affiliations

    • Institute of Hematology and Medical Oncology, “L. & A. Seràgnoli,” University of Bologna, Bologna, Italy
    • ,
  • Carolina Terragna

      Affiliations

    • Institute of Hematology and Medical Oncology, “L. & A. Seràgnoli,” University of Bologna, Bologna, Italy
    • ,
  • Pierluigi Zinzani

      Affiliations

    • Institute of Hematology and Medical Oncology, “L. & A. Seràgnoli,” University of Bologna, Bologna, Italy
    • ,
  • Antonio Curti

      Affiliations

    • Institute of Hematology and Medical Oncology, “L. & A. Seràgnoli,” University of Bologna, Bologna, Italy
    • ,
  • Simonetta Rizzi

      Affiliations

    • Institute of Hematology and Medical Oncology, “L. & A. Seràgnoli,” University of Bologna, Bologna, Italy
    • ,
  • Simona Taioli

      Affiliations

    • Institute of Hematology and Medical Oncology, “L. & A. Seràgnoli,” University of Bologna, Bologna, Italy
    • ,
  • Valeria Giudice

      Affiliations

    • Immunohematology Service and Blood Bank, S. Orsola-Malpighi Hospital, Bologna, Italy
    • ,
  • Alessandra D’Addio

      Affiliations

    • Institute of Hematology and Medical Oncology, “L. & A. Seràgnoli,” University of Bologna, Bologna, Italy
    • ,
  • Gabriele Gugliotta

      Affiliations

    • Institute of Hematology and Medical Oncology, “L. & A. Seràgnoli,” University of Bologna, Bologna, Italy
    • ,
  • Roberto Conte

      Affiliations

    • Immunohematology Service and Blood Bank, S. Orsola-Malpighi Hospital, Bologna, Italy
    • ,
  • Michele Baccarani

      Affiliations

    • Institute of Hematology and Medical Oncology, “L. & A. Seràgnoli,” University of Bologna, Bologna, Italy
    • ,
  • Roberto M. Lemoli

      Affiliations

    • Institute of Hematology and Medical Oncology, “L. & A. Seràgnoli,” University of Bologna, Bologna, Italy

Received 2 May 2007 ,Accepted 10 July 2007.

  • Image Result

    Immunologic reconstitution of normal and leukemic B lymphocytes in CLL patients after transplantation of highly purified autologous CD133+ HSCs.

    Immunologic reconstitution of normal and leukemic B lymphocytes in CLL patients after transplantation of highly purified autologous CD133+ HSCs.

  • Image Result

    Immunologic reconstitution of T lymphocytes and NK cells in CLL patients after transplantation of highly purified autologous CD133+ HSCs.

    Immunologic reconstitution of T lymphocytes and NK cells in CLL patients after transplantation of highly purified autologous CD133+ HSCs.

PII: S1083-8791(07)00347-3

doi: 10.1016/j.bbmt.2007.07.004

Biology of Blood and Marrow Transplantation
Volume 13, Issue 10 , Pages 1224-1232 , October 2007

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