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Volume 13, Issue 10 , Pages 1233-1243 , October 2007

Similar Outcomes of Cryopreserved Allogeneic Peripheral Stem Cell Transplants (PBSCT) Compared to Fresh Allografts

Dong Hwan Kim
- Department of Hematology/Medical Oncology, Princess Margaret Hospital, University Health Network, University of Toronto, Toronto, Canada
- Department of Hematology and Oncology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
Nazir Jamal
- Department of Hematology/Medical Oncology, Princess Margaret Hospital, University Health Network, University of Toronto, Toronto, Canada
Ronnie Saragosa
- Department of Hematology/Medical Oncology, Princess Margaret Hospital, University Health Network, University of Toronto, Toronto, Canada
David Loach
- Department of Hematology/Medical Oncology, Princess Margaret Hospital, University Health Network, University of Toronto, Toronto, Canada
Janice Wright
- Department of Hematology/Medical Oncology, Princess Margaret Hospital, University Health Network, University of Toronto, Toronto, Canada
Vikas Gupta
- Department of Hematology/Medical Oncology, Princess Margaret Hospital, University Health Network, University of Toronto, Toronto, Canada
John Kuruvilla
- Department of Hematology/Medical Oncology, Princess Margaret Hospital, University Health Network, University of Toronto, Toronto, Canada
Jeffrey H. Lipton
- Department of Hematology/Medical Oncology, Princess Margaret Hospital, University Health Network, University of Toronto, Toronto, Canada
Mark Minden
- Department of Hematology/Medical Oncology, Princess Margaret Hospital, University Health Network, University of Toronto, Toronto, Canada
Hans A. Messner
- Department of Hematology/Medical Oncology, Princess Margaret Hospital, University Health Network, University of Toronto, Toronto, Canada
- Correspondence and reprint requests: Hans A. Messner, MD/PhD, Department of Hematology/Medical Oncology, Princess Margaret Hospital, University Health Network, Toronto, ON, Canada, M5G 2M9.

Received 9 May 2007 ,Accepted 5 July 2007.

Engraftment kinetics of neutrophils (A), platelets (B), and lymphocytes (C) after cryopreserved and fresh PBSCT. D, Shows similar serial recoveries of lymphocyte counts after cryopreserved and fresh P

Engraftment kinetics of neutrophils (A), platelets (B), and lymphocytes (C) after cryopreserved and fresh PBSCT. D, Shows similar serial recoveries of lymphocyte counts after cryopreserved and fresh PBSCT.
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Incidence of acute (A) and cGVHD (B) after cryopreserved and fresh PBSCT.

Incidence of acute (A) and cGVHD (B) after cryopreserved and fresh PBSCT.
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Overall survival, nonrelapse mortality, and recurrence rates of patients receiving cryopreserved or freshly procured allografts.

Overall survival, nonrelapse mortality, and recurrence rates of patients receiving cryopreserved or freshly procured allografts.
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Frequency of clonogenic hematopoietic progenitors in PBSC preparation before cryopreservation and after thawing. Colony counts after 14 days’ incubation of 5 × 104 TNCs. Abbreviations: CFU-GM, colony-

Frequency of clonogenic hematopoietic progenitors in PBSC preparation before cryopreservation and after thawing. Colony counts after 14 days’ incubation of 5 × 10⁴ TNCs. Abbreviations: CFU-GM, colony-forming units granulocyte-macrophage; BFU-E, Burst-forming units erythroid; CFU-MEG, colony-forming units megakaryocyte; CFU-GEMM, colony-forming units granulocyte-erythrocyte-monocyte-megakaryocyte.
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