Biology of Blood and Marrow Transplantation
Volume 13, Issue 11 , Pages 1358-1368 , November 2007

Status of Donor-Recipient HLA Class I Ligands and Not the KIR Genotype Is Predictive for the Outcome of Unrelated Hematopoietic Stem Cell Transplantation in Beta-Thalassemia Patients

  • Giorgio La Nasa

      Affiliations

    • Cattedra di Ematologia, Centro Trapianti Midollo Osseo, Ospedale R. Binaghi-ASL 8, Dipartimento di Scienze Mediche Internistiche, Università di Cagliari, Cagliari, Italy
    • Corresponding Author InformationCorrespondence and reprint requests: Prof. Giorgio La Nasa, Centro Trapianti Midollo Osseo, Ospedale “R. Binaghi,” ASL No. 8, Via Is Guadazzonis, 3, 09126 Cagliari, Italy.
    • ,
  • Roberto Littera

      Affiliations

    • Centro Regionale Trapianti, Ospedale R. Binaghi-ASL 8, Cagliari, Italy
    • ,
  • Franco Locatelli

      Affiliations

    • Oncoematologia Pediatrica, Università di Pavia, Fondazione IRCCS Policlinico S. Matteo, Pavia, Italy
    • ,
  • Claudio Giardini

      Affiliations

    • Unità Operativa di Ematologia, Centro Trapianti di Midollo Osseo di Muraglia, Ospedale S. Salvatore, Pesaro, Italy
    • ,
  • Arianna Ventrella

      Affiliations

    • Cattedra di Genetica Medica, Ospedale R. Binaghi-ASL 8, Dipartimento di Scienze Mediche Internistiche, Università di Cagliari, Cagliari, Italy
    • ,
  • Marina Mulargia

      Affiliations

    • Cattedra di Genetica Medica, Ospedale R. Binaghi-ASL 8, Dipartimento di Scienze Mediche Internistiche, Università di Cagliari, Cagliari, Italy
    • ,
  • Adriana Vacca

      Affiliations

    • Cattedra di Ematologia, Centro Trapianti Midollo Osseo, Ospedale R. Binaghi-ASL 8, Dipartimento di Scienze Mediche Internistiche, Università di Cagliari, Cagliari, Italy
    • ,
  • Nicola Orrù

      Affiliations

    • Cattedra di Genetica Medica, Ospedale R. Binaghi-ASL 8, Dipartimento di Scienze Mediche Internistiche, Università di Cagliari, Cagliari, Italy
    • ,
  • Sandro Orrù

      Affiliations

    • Cattedra di Genetica Medica, Ospedale R. Binaghi-ASL 8, Dipartimento di Scienze Mediche Internistiche, Università di Cagliari, Cagliari, Italy
    • ,
  • Eugenia Piras

      Affiliations

    • Cattedra di Ematologia, Centro Trapianti Midollo Osseo, Ospedale R. Binaghi-ASL 8, Dipartimento di Scienze Mediche Internistiche, Università di Cagliari, Cagliari, Italy
    • ,
  • Giada Giustolisi

      Affiliations

    • Centro Regionale Trapianti, Ospedale R. Binaghi-ASL 8, Cagliari, Italy
    • ,
  • Daniela Lisini

      Affiliations

    • Oncoematologia Pediatrica, Università di Pavia, Fondazione IRCCS Policlinico S. Matteo, Pavia, Italy
    • ,
  • Sonia Nesci

      Affiliations

    • Unità Operativa di Ematologia, Centro Trapianti di Midollo Osseo di Muraglia, Ospedale S. Salvatore, Pesaro, Italy
    • ,
  • Giovanni Caocci

      Affiliations

    • Cattedra di Ematologia, Centro Trapianti Midollo Osseo, Ospedale R. Binaghi-ASL 8, Dipartimento di Scienze Mediche Internistiche, Università di Cagliari, Cagliari, Italy
    • ,
  • Carlo Carcassi

      Affiliations

    • Centro Regionale Trapianti, Ospedale R. Binaghi-ASL 8, Cagliari, Italy
    • Cattedra di Genetica Medica, Ospedale R. Binaghi-ASL 8, Dipartimento di Scienze Mediche Internistiche, Università di Cagliari, Cagliari, Italy

Received 14 March 2007 ,Accepted 20 July 2007.

  • Image Result

    Kaplan-Meier probabilities of overall survival, thalassemia-free survival and cumulative incidence of mortality and rejection in 45 thalassemia patients transplanted from an unrelated donor.

    Kaplan-Meier probabilities of overall survival, thalassemia-free survival and cumulative incidence of mortality and rejection in 45 thalassemia patients transplanted from an unrelated donor.

  • Image Result

    Influence of heterozygosity for the HLA-Cw ligand groups 1 and 2 (C1/C2) on the incidence of grade II-IV aGVHD in 45 thalassemia patients transplanted from an unrelated donor. (C1/C2 patients = 22, ev

    Influence of heterozygosity for the HLA-Cw ligand groups 1 and 2 (C1/C2) on the incidence of grade II-IV aGVHD in 45 thalassemia patients transplanted from an unrelated donor. (C1/C2 patients = 22, events = 10; C1/C1 patients = 9, events = 0; C2/C2 patients = 14, events = 2).

  • Image Result
    Influence of homozygosity for the HLA-Cw ligand groups (C1/C1 or C2/C2) on the cumulative incidence of rejection in 45 thalassemia patients transplanted from an unrelated donor. (C1/C1 patients = 9, e

    Influence of homozygosity for the HLA-Cw ligand groups (C1/C1 or C2/C2) on the cumulative incidence of rejection in 45 thalassemia patients transplanted from an unrelated donor. (C1/C1 patients = 9, events = 3; C2/C2 patients = 14, events = 4; C1/C2 patients = 22, events = 0).

  • Image Result
    Comparison of the probabilities of thalassemia-free survival (TFS) between 22 C1/C2 heterozygotes (events = 18) and 23 C1/C1 or C2/C2 homozygotes (C1/C1 patients = 9, events 6; C2/C2 patients = 14, ev

    Comparison of the probabilities of thalassemia-free survival (TFS) between 22 C1/C2 heterozygotes (events = 18) and 23 C1/C1 or C2/C2 homozygotes (C1/C1 patients = 9, events 6; C2/C2 patients = 14, events = 8).

  • Image Result
    Impact of the presence of the HLA-A11 KIR antigen on the incidence of grade II-IV aGVHD in 45 thalassemia patients transplanted from an unrelated donor. (HLA-A11 positive patients = 11, events = 0; HL

    Impact of the presence of the HLA-A11 KIR antigen on the incidence of grade II-IV aGVHD in 45 thalassemia patients transplanted from an unrelated donor. (HLA-A11 positive patients = 11, events = 0; HLA-A11 negative patients = 34, events 12).

PII: S1083-8791(07)00369-2

doi: 10.1016/j.bbmt.2007.07.011

Biology of Blood and Marrow Transplantation
Volume 13, Issue 11 , Pages 1358-1368 , November 2007

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