Biology of Blood and Marrow Transplantation
Volume 13, Issue 11 , Pages 1369-1379 , November 2007

Central Nervous System Complications after Allogeneic Hematopoietic Stem Cell Transplantation: Incidence, Manifestations, and Clinical Significance

  • Deborah Siegal

      Affiliations

    • Blood and Marrow Transplant Program, University Health Network, Toronto, Canada
    • ,
  • Anne Keller

      Affiliations

    • Department of Radiology, University Health Network, Toronto, Canada
    • ,
  • Wei Xu

      Affiliations

    • Department of Biostatistics, Princess Margaret Hospital, University of Toronto, Toronto, Canada
    • ,
  • Sandeep Bhuta

      Affiliations

    • Department of Radiology, University Health Network, Toronto, Canada
    • ,
  • Dong Hwan Kim

      Affiliations

    • Blood and Marrow Transplant Program, University Health Network, Toronto, Canada
    • ,
  • John Kuruvilla

      Affiliations

    • Blood and Marrow Transplant Program, University Health Network, Toronto, Canada
    • ,
  • Jeffrey H. Lipton

      Affiliations

    • Blood and Marrow Transplant Program, University Health Network, Toronto, Canada
    • ,
  • Hans Messner

      Affiliations

    • Blood and Marrow Transplant Program, University Health Network, Toronto, Canada
    • ,
  • Vikas Gupta

      Affiliations

    • Blood and Marrow Transplant Program, University Health Network, Toronto, Canada
    • Corresponding Author InformationCorrespondence and reprint requests: Vikas Gupta, MD, MRCP, MRCPath, Blood and Marrow Transplant Program, Princess Margaret Hospital, Suite 5-217, 610 University Avenue, Toronto, M5G 2 M9, ON, Canada.

Received 22 June 2007 ,Accepted 24 July 2007.

  • Image Result

    FLAIR axial images of brain show mild (A), moderate (B), and severe (C and D) forms of PRES corresponding with severity grading of 1, 2, and 3, respectively.

    FLAIR axial images of brain show mild (A), moderate (B), and severe (C and D) forms of PRES corresponding with severity grading of 1, 2, and 3, respectively.

  • Image Result

    The cumulative incidences of all CNS complications and PRES at days 30, 100, 180, and 365 were 9%, 18%, 20%, and 23%, and 4%, 6%, 7%, and 7%, respectively.

    The cumulative incidences of all CNS complications and PRES at days 30, 100, 180, and 365 were 9%, 18%, 20%, and 23%, and 4%, 6%, 7%, and 7%, respectively.

  • Image Result

    Kaplan-Meier plots of overall survival in patients with and without CNS complications (within 100 days posttransplant) and PRES. In comparison to their counterparts, survival at 1-year was significant

    Kaplan-Meier plots of overall survival in patients with and without CNS complications (within 100 days posttransplant) and PRES. In comparison to their counterparts, survival at 1-year was significantly reduced in patients who developed CNS complications in the first 100 days posttransplant (28% versus 72%, P < .0001) (A), and PRES (27% versus 67%, P < .0001) (B).

PII: S1083-8791(07)00370-9

doi: 10.1016/j.bbmt.2007.07.013

Biology of Blood and Marrow Transplantation
Volume 13, Issue 11 , Pages 1369-1379 , November 2007

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