Biology of Blood and Marrow Transplantation
Volume 13, Issue 12 , Pages 1461-1468 , December 2007

Peripheral Blood Grafts from Unrelated Donors Are Associated with Increased Acute and Chronic Graft-versus-Host Disease without Improved Survival

  • Mary Eapen

      Affiliations

    • Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, Wisconsin
    • Corresponding Author InformationCorrespondence and reprint requests: Mary Eapen, M.D., Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, 8701 Watertown Plank Road, P.O. Box 26509, Milwaukee, WI 53226.
    • ,
  • Brent R. Logan

      Affiliations

    • Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, Wisconsin
    • ,
  • Dennis L. Confer

      Affiliations

    • National Marrow Donor Program, Minneapolis, Minnesota
    • ,
  • Michael Haagenson

      Affiliations

    • Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, Wisconsin
    • ,
  • John E. Wagner

      Affiliations

    • University of Minnesota, Minneapolis, Minnesota
    • ,
  • Daniel J. Weisdorf

      Affiliations

    • University of Minnesota, Minneapolis, Minnesota
    • ,
  • John R. Wingard

      Affiliations

    • Shands Hospital at the University of Florida, Gainesville, Florida
    • ,
  • Scott D. Rowley

      Affiliations

    • Hackensack University Medical Center, Hackensack, New Jersey
    • ,
  • David Stroncek

      Affiliations

    • National Institutes of Health, Department of Transfusion Medicine, Bethesda, Maryland
    • ,
  • Adrian P. Gee

      Affiliations

    • Baylor College of Medicine, Houston, Texas
    • ,
  • Mary M. Horowitz

      Affiliations

    • Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, Wisconsin
    • ,
  • Claudio Anasetti

      Affiliations

    • H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida

Received 12 April 2007 ,Accepted 23 August 2007.

References 

  1. Champlin RE, Schmitz N, Horowitz MM, et al. Blood stem cells compared with bone marrow as a source of hematopoietic cells for allogeneic transplantation (IBMTR Histocompatibility and Stem Cell Sources Working Committee and the European Group for Blood and Marrow Transplantation (EBMT)). Blood. 2000;95:3702–3709
  2. Bensinger WI, Martin PJ, Storer B, et al. Transplantation of bone marrow as compared with peripheral-blood cells from HLA-identical relatives in patients with hematologic cancers. N Engl J Med. 2001;344:175–181
  3. Schmitz N, Beksac M, Hasenclever D, et al. Transplantation of mobilized peripheral blood cells to HLA-identical siblings with standard-risk leukemia. Blood. 2002;100:761–767
  4. Allogeneic peripheral blood stem-cell compared with bone marrow transplantation in the management of hematologic malignancies: an individual patient data meta-analysis of nine randomized trials. J Clin Oncol. 2005;23:5074–5087
  5. Flowers ME, Parker PM, Johnston LJ, et al. Comparison of chronic graft-versus-host disease after transplantation of peripheral blood stem cells versus bone marrow in allogeneic recipients: long-term follow-up of a randomized trial. Blood. 2002;100:415–419
  6. Mohty M, Kuentz M, Michallet M, et al. Chronic graft-versus-host disease after allogeneic blood stem cell transplantation: long-term results of a randomized study. Blood. 2002;100:3128–3134
  7. Blau IW, Basara N, Lentini G, et al. Feasibility and safety of peripheral blood stem cell transplantation from unrelated donors: results of a single-center study. Bone Marrow Transplant. 2001;27:27–33
  8. Remberger M, Ringden O, Blau IW, et al. No difference in graft-versus-host disease, relapse, and survival comparing peripheral stem cells to bone marrow using unrelated donors. Blood. 2001;98:1739–1745
  9. Garderet L, Labopin M, Gorin NC, et al. Patients with acute lymphoblastic leukaemia allografted with a matched unrelated donor may have a lower survival with a peripheral blood stem cell graft compared to bone marrow. Bone Marrow Transplant. 2003;31:23–29
  10. Remberger M, Beelen DW, Fauser A, et al. Increased risk of extensive chronic graft-versus-host disease after allogeneic peripheral blood stem cell transplantation using unrelated donors. Blood. 2005;105:548–551
  11. Farag SS, Bacigalupo A, Eapen M, et al. The effect of KIR ligand incompatibility on the outcome of unrelated donor transplantation: a report from the center for international blood and marrow transplant research, the European blood and marrow transplant registry, and the Dutch registry. Biol Blood Marrow Transplant. 2006;12:876–884
  12. Glucksberg H, Storb R, Fefer A, et al. Clinical manifestations of graft-versus-host disease in human recipients of marrow from HL-A-matched sibling donors. Transplantation. 1974;18:295-230
  13. Przepiorka D, Weisdorf D, Martin P, et al. 1994 Consensus conference on acute GVHD grading. Bone Marrow Transplant. 1995;15:825–828
  14. Atkinson K, Horowitz MM, Gale RP, et al. Risk factors for chronic graft-versus-host disease after HLA-identical sibling bone marrow transplantation. Blood. 1990;75:2459–2464
  15. Klein JP, Moeschberger ML. Survival Analysis: Techniques of Censored and Truncated Data. 2nd ed.. New York: Springer-Verlag; 2003;
  16. Cox DR. Regression models and life tables. Stat Soc B. 1972;4:187–200
  17. Andersen PK, Klein JP, Zhang MJ. Testing for centre effects in multi-centre survival studies: a Monte Carlo comparison of fixed and random effects tests. Stat Med. 1999;18:1489–1500
  18. Clark TG, Altman DG, De Stavola BL. Quantification of the completeness of follow-up. Lancet. 2002;359:1309–1310
  19. Hurley CK, Frenandez-Vina M, Hildebrand WH, et al. A high degree of HLA disparities arises from limited allelic diversity: Analysis of 1775 unrelated bone marrow transplant donor-recipient pairs. Hum Immunol. 2007;68:30–40
  20. Schmitz N, Eapen M, Horowitz MM, et al. Long-term outcome of patients given transplants of mobilized blood or bone marrow: a report from the International Bone Marrow Transplant Registry and the European Group for Blood and Marrow Transplantation. Blood. 2006;108:4288–4290

PII: S1083-8791(07)00385-0

doi: 10.1016/j.bbmt.2007.08.006

Biology of Blood and Marrow Transplantation
Volume 13, Issue 12 , Pages 1461-1468 , December 2007

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