Biology of Blood and Marrow Transplantation
Volume 13, Issue 12 , Pages 1477-1486 , December 2007

Umbilical Cord Mesenchymal Stem Cells: Adjuvants for Human Cell Transplantation

Received 3 July 2007 ,Accepted 30 August 2007.

References 

  1. Le Blanc K, Ringden O. Immunobiology of human mesenchymal stem cells and future use in hematopoietic stem cell transplantation. Biol Blood Marrow Transplant. 2005;11:321–324
  2. Aggarwal S, Pittenger F. Human mesenchymal stem cells modulate allogeneic immune cell responses. Blood. 2005;105:1815–1822
  3. Horwitz EM, Gordon PL, Koo WK, et al. Isolated allogeneic bone marrow–derived mesenchymal cells engraft and stimulate growth in children with osteogenesis imperfecta: implications for cell therapy of bone. Proc Natl Acad Sci U S A. 2002;99:8932–8937
  4. Hare JM, Dib N, Traverse JH, et al. A double-blind, randomized, placebo controlled clinical trial of allogeneic mesenchymal stem cells for the treatment of patients with acute myocardial infarction. Abstract 2405-3, presented at the American College of Cardiology Summit, New Orleans, LA, March 25, 2007.
  5. Le Blanc K, Rasmusson I, Sundberg B, et al. Treatment of severe acute graft-versus-host disease with third-party haploidentical mesenchymal stem cells. Lancet. 2004;363:1439–1441
  6. Kebriaei P, Isola L, Bahceci E, et al. Phase II trial of prochymal (ex-vivo cultured adult human mesenchymal stem cells) and corticosteroids as primary treatment for acute graft-vs-host disease (aGVHD). [abstract] Blood. 2006;108:922a
  7. Campagnoli C, Roberts IA, Kumar S, et al. Identification of mesenchymal stem/progenitor cells in human first-trimester fetal blood, liver, and bone marrow. Blood. 2001;98:2396–2402
  8. Zhang Y, Lib C, Jianga X, et al. Human placenta–derived mesenchymal progenitor cells support culture expansion of long-term culture-initiating cells from cord blood CD34+ cells. Exp Hematol. 2004;32:657–664
  9. Sarugaser R, Lickorish D, Baksh D, et al. Human umbilical cord perivascular (HUCPV) cells: a source of mesenchymal progenitors. Stem Cells. 2005;23:220–229
  10. Miki T, Lehmann T, Hongbo C, et al. Stem cell characteristics of amniotic epithelial cells. Stem Cells. 2005;23:1549–1559
  11. Koegler G, Radke T, Lefort A, et al. Cytokine production and hematopoiesis supporting activity of cord blood–derived unrestricted somatic stem cells. Exp Hematol. 2005;33:573–583
  12. Carlson BM. Human embryology and developmental biology (3rd ed). 2004.
  13. Wang HS, Hung SC, Peng ST, et al. Mesenchymal stem cells in the Wharton's jelly of the human umbilical cord. Stem Cells. 2004;22:1330–1337
  14. Mitchell KE, Weiss ML, Mitchell BM, et al. Matrix cells from Wharton's jelly form neurons and glia. Stem Cells. 2003;21:50–60
  15. Weiss ML, Medicetty S, Bledsoe AR, et al. Human umbilical cord matrix stem cells: preliminary characterization and effect of transplantation in a rodent model of Parkinson's disease. Stem Cells. 2006;24:781–792
  16. Lu LL, Liu YJ, Yang SG, et al. Isolation and characterization of human umbilical cord mesenchymal stem cells with hematopoiesis: supportive function and other potentials. Haematologica. 2006;91:1017–1026
  17. Noort WA, Kruisselbrink AB, In't Anker P, et al. Mesenchymal stem cells promote engraftment of human umbilical cord blood–derived CD34(+) cells in NOD/SCID mice. Exp Hematol. 2002;30:870–878
  18. In't Anker P, Noort WA, Kruisselbrink AB. Nonexpanded primary lung and bone marrow–derived mesenchymal cells promote the engraftment of umbilical cord blood–derived CD34(+) cells in NOD/SCID mice. Exp Hematol. 2003;31:881–889
  19. Vanderson R, Comish J, Sievers EL, et al. Comparison of outcomes of unrelated bone marrow and umbilical cord blood transplants in children with acute leukemia. Blood. 2001;97:2962–2971
  20. Laughlin MJ, Eapen M, Rubinstein P, et al. Outcomes after transplantation of cord blood or bone marrow from unrelated donors in adults with leukemia. N Eng J Med. 2004;351:2265–2275
  21. Rocha V, Labopin M, Sanz G, et al. Transplants of umbilical cord blood or bone marrow from unrelated donors in adults with acute leukemia. N Engl J Med. 2004;351:2276–2285
  22. Barker JN, Krepski TP, DeFor TE, et al. Searching for unrelated donor hematopoietic stem cells: availability and speed of umbilical cord blood versus bone marrow. Biol Blood Marrow Transplant. 2002;8:257–260
  23. Grewal SS, Barker JN, Davies SM, et al. Unrelated donor hematopoietic cell transplantation: marrow or umbilical cord blood?. Blood. 2003;101:4233–4244
  24. Wagner JE, Barker JN, DeFor TE, et al. Transplantation of unrelated donor umbilical cord blood in 102 patients with malignant and nonmalignant diseases: influence of CD34 cell dose and HLA disparity on treatment-related mortality and survival. Blood. 2002;100:1611–1618
  25. McNiece I, Gluckman E, Wagner JE, et al. Ex vivo expansion of umbilical cord blood hemopoietic stem and progenitor cells. Exp Hematol. 2004;32:409–413
  26. Muguruma Y, Yahata T, Miyatake H, et al. Reconstitution of the functional human hematopoietic microenvironment derived from human mesenchymal stem cells in the murine bone marrow compartment. Blood. 2006;107:1878
  27. Shahdadfar A, Fronsdal K, Haug T, et al. In vitro expansion of human mesenchymal stem cells: choice of serum is a determinant of cell proliferation, differentiation, gene expression, and transcriptome stability. Stem Cells. 2005;23:1357–1366
  28. Dimarkis I, Levicar N. Cell culture medium composition and translational adult bone marrow–derived stem cell research. Stem Cells. 2006;24:1407–1408
  29. Sotiropoulou PA, Perez SA, Salagianni M, et al. Characterization of the optimal culture conditions for clinical scale production of human mesenchymal stem cells. Stem Cells. 2006;24:462–471
  30. Vogel JP, Szalay K, Geiger F, et al. Platelet-rich plasma improves expansion of human mesenchymal stem cells and retains differentiation capacity and in vivo bone formation in calcium phosphate ceramics. Platelets. 2006;7:462–469
  31. Barker JN, Weisdorf DJ, DeFor TE, et al. Transplantation of two partially HLA-matched umbilical cord blood units to enhance engraftment in adults with hematologic malignancy. Blood. 2005;105:1343–1347
  32. Angelopoulou M, Novelli E, Grove JE, et al. Co-transplantation of human mesenchymal stem cells enhances human myelopoiesis and megakaryocytopoiesis in NOD/SCID mice. Exp Hematol. 2003;31:413–420
  33. Robinson SN, Ng J, Yang H, et al. Superior ex vivo cord blood expansion following co-culture with bone marrow–derived mesenchymal cells. Bone Marrow Transplant. 2006;37:359–366
  34. Koç ON, Gerson SL, Cooper BW, et al. Rapid hematopoietic recovery after co-infusion of autologous blood stem cells and culture-expanded marrow mesenchymal stem cells in advanced breast cancer patients receiving high-dose chemotherapy. J Clin Oncol. 2000;18:307–316
  35. Lazarus HM, Koc ON, Devine SM. Co-transplantation of HLA-identical sibling culture-expanded mesenchymal stem cells and hematopoietic stem cells in hematologic malignancy patients. Biol Blood Marrow Transplant. 2005;11:389–398
  36. Li Q, Hisha H, Yasumizu R, et al. Analysis of very early hematopoietic regeneration after bone marrow transplantation: comparison of intravenous and intrabone marrow routes. Stem Cells. 2007;25:1186–1194
  37. Mazurier F, Doedens M, Gan OI, et al. Rapid myeloerythroid repopulation after intrafemoral transplantation of NOD-SCID mice reveals a new class of human stem cells. Nat Med. 2003;9:959–963
  38. Tuncer HT, Betancur M, Boissel L, et al. Ex-vivo expansion and mRNA transfection of cord blood–derived natural killer cells with preserved cytotoxicity. [abstract] Blood. 2006;108:1045a
  39. Chapel A, Bertho JM, Bensidhoum M, et al. Mesenchymal stem cells home to injured tissues when co-infused with hematopoietic cells to treat a radiation-induced multi-organ failure syndrome. J Gene Med. 2003;5:1028–1038
  40. Studeny M, Marini FC, Champlin RE, et al. Bone marrow–derived mesenchymal stem cells as vehicles for interferon-ß delivery into tumors. Cancer Res. 2002;62:3603–3608
  41. Stagg J, Lejeune L, Paquin A, et al. Marrow stromal cells for interleukin-2 delivery in cancer immunotherapy. Hum Gene Ther. 2004;15:597–608

PII: S1083-8791(07)00437-5

doi: 10.1016/j.bbmt.2007.08.048

Biology of Blood and Marrow Transplantation
Volume 13, Issue 12 , Pages 1477-1486 , December 2007