Biology of Blood and Marrow Transplantation
Volume 14, Issue 1 , Pages 16-27 , January 2008

Importance of Interleukin-7 in the Development of Experimental Graft-Versus-Host Disease

  • Brile Chung

      Affiliations

    • Division of Stem Cell Transplantation, Department of Pediatrics, Stanford University School of Medicine, Stanford, California
  • ,
  • Eric Dudl

      Affiliations

    • Division of Research Immunology/Bone Marrow Transplantation, The Saban Research Institute of Children's Hospital Los Angeles, Los Angeles, California
  • ,
  • Akira Toyama

      Affiliations

    • Division of Research Immunology/Bone Marrow Transplantation, The Saban Research Institute of Children's Hospital Los Angeles, Los Angeles, California
  • ,
  • Lora Barsky

      Affiliations

    • Division of Research Immunology/Bone Marrow Transplantation, The Saban Research Institute of Children's Hospital Los Angeles, Los Angeles, California
  • ,
  • Kenneth I. Weinberg

      Affiliations

    • Division of Stem Cell Transplantation, Department of Pediatrics, Stanford University School of Medicine, Stanford, California
    • Corresponding Author InformationCorrespondence and reprint requests: Kenneth I Weinberg, MD, Division of Stem Cell Transplantation, Department of Pediatrics, Stanford University Medical Center, 1000 Welch Road, Suite 300, Palo Alto, CA 94304.

Received 12 July 2007 ,Accepted 18 September 2007.

References 

  1. Ferrara JML. Cytokine dysregulation as a mechanism of graft-versus-host disease. Curr Opin Immunol. 1993;5:794–799
  2. Antin JH, Verra JL. Cytokine dysregulation and acute graft-versus-host disease. Blood. 1992;80:2964–2968
  3. Sprent J, Schaefer M, Korngold R. Role of T-cell subsets in lethal graft-versus-host disease (GVHD) directed to class I versus class II H-2 differences. II. Protective effects of L3T4+ cells in anti-class II H-2 differences. J Immunol. 1990;144:2946–2954
  4. Korngold R, Sprent J. Bone Marrow Transplantation. London: Blackwell Scientific; 1994;p. 220–230
  5. Nikolic B, Lee S, Bronson RT, et al. Th1 and Th2 mediate acute graft-versus-host disease, each with distinct end-organ targets. J Clin Invest. 2000;105:1289–1298
  6. Sprent J, Schaefer J, Gao E, et al. Role of T cell subsets in lethal graft-versus-host disease (GVHD) directed to class I versus class II H-2 differences I. L3T4+ cells can either augment or retard GVHD elicited by Lyt-2+ cells in class I-different hosts. J Exp Med. 1988;167:556–560
  7. Ferrara JL, Deeg HJ. Graft-versus-host disease. N Engl J Med. 1991;324:667–674
  8. Weinberg KI, Annett G, Kashyap A, et al. The effect of thymic function on immunocompetence following bone marrow transplantation. Biol Blood Marrow Transplant. 1995;1:18–23
  9. Chung B, Barbra-Burnham L, Barsky L, et al. Radiosensitivity of thymic IL-7 production and thymopoiesis after bone marrow transplant (BMT). Blood. 2001;99:4592–4600
  10. Atkinson K. Reconstruction of the hematopoietic and immune systems after marrow transplantation. Bone Marrow Transplant. 1990;5:209–226
  11. Lum LG. The kinetics of immune reconstitution after human marrow transplantation. Blood. 1987;69:369–380
  12. Miller RA, Daley J, Ghalie R, et al. Clonal analysis of T-cell deficiencies in autotransplant recipients. Blood. 1991;77:1845–1850
  13. Rodewald HR, Kretzschmar K, Swat W, et al. Intrathymically expressed c-kit ligand (stem cell factor) is a major factor driving expansion of very immature thymocytes in vivo. Immunity. 1995;3:313–319
  14. Murray R, Suda T, Wrighton N, et al. IL-7 is a growth and maintenance factor for mature and immature thymocyte subsets. Int Immunol. 1989;169:707–716
  15. Pechon JJ, Morrissey PJ, Grabstein KH, et al. Early lymphocyte expansion is severely impaired in interleukin-7 receptor–deficient mice. J Exp Med. 1994;180:1955–1960
  16. Von Freeden-Jeffry U, Vieira P, Lucian LA, et al. Lymphopenia in interleukin (IL)-7 gene–deleted mice identifies IL-7 as a nonredundant cytokine. J Exp Med. 1995;181:1519–1526
  17. Somberg R, Robinson JP, Felsburg P. T lymphocyte development and function in dogs with X-linked severe combined immune deficiency. J Immunol. 1994;153:4006–4015
  18. Noguchi M, Yi H, Rosenblatt HM, et al. Interleukin-2 receptor γ-chain mutation results in X-linked severe combined immune deficiency in humans. Cell. 1993;73:147–157
  19. Bolotin E, Smith S, Smogoreswka EM, et al. Enhancement of thymopoiesis after bone marrow transplant by in vivo IL-7. Blood. 1996;88:1887–1894
  20. Mackall CL, Fry TJ, Bare C, et al. IL-7 increases both thymic-dependent and thymic-independent T-cell regeneration after bone marrow transplantation. Blood. 2001;97:1491–1497
  21. Sudo TS, Nishikawa N, Ohno N, et al. Expression and function of the interleukin-7 receptor in murine lymphocytes. Proc Natl Acad Sci U S A. 1993;90:9125–9129
  22. Maraskovsky E, Teepe M, Morrissey PJ, et al. Impaired survival and proliferation in IL-7 receptor–deficient peripheral T cells. J Immunol. 1996;157:5315–5323
  23. Tan JT, Dudl E, LeRoy E, et al. IL-7 is critical for homeostatic proliferation and survival of naïve T cells. Proc Natl Acad Sci U S A. 2001;98:8732–8737
  24. Schluns KS, Kieper WC, Jameson SC, et al. Interleukin-7 mediates the homeostasis of naïve and memory CD8 T cells in vivo. Nat Immunol. 2000;1:426–432
  25. Kondrack RM, Harbertson J, Tan JT, et al. Interleukin-7 regulates the survival and generation of memory CD4 cells. J Exp Med. 2003;198:1797–1806
  26. Vella AT, Dow S, Potter TA, et al. Cytokine-induced survival of activated T cells in vitro and in vivo. Proc Natl Acad Sci U S A. 1998;95:3810–3815
  27. Gringhuis SI, de Leij LF, Verschuren EW, et al. Interleukin-7 up-regulates the interleukin-2 gene expression in activated human T lymphocytes at the transcriptional level by enhancing the DNA binding activities of both nuclear factor of activated T cells and activator protein-1. Blood. 1997;90:2690–2700
  28. van Roon JA, Glaudemans KA, Bijlsma JW, et al. Interleukin-7 stimulates tumour necrosis factor alpha and Th1 cytokine production in joints of patients with rheumatoid arthritis. Ann Rheum Dis. 2003;62:113–119
  29. Fukui T, Katamura K, Abe N, et al. IL-7 proliferation, variable cytokine-producing ability and IL-2 responsiveness in naïve CD4+ T cells from human cord blood. Immunol Lett. 1997;59:21–28
  30. Alpdogan O, Schmaltz C, Muriglan SJ, et al. Administration of interleukin-7 after allogeneic bone marrow transplantation improves immune reconstitution without aggravating graft-versus-host disease. Blood. 2001;98:2256–2265
  31. Sinha ML, Fry TJ, Fowler DH, et al. Interleukin-7 worsens graft-versus-host disease. Blood. 2002;100:2642–2649
  32. Alpdogan O, Muriglan SJ, Eng JM, et al. IL-7 enhances peripheral T cell reconstitution after allogeneic hematopoietic stem cell transplantation. J Clin Invest. 2003;112:1095–1107
  33. Cooke KR, Kobzik L, Martin TR, et al. An experimental model of idiopathic pneumonia syndrome after bone marrow transplantation. I. The role of minor H antigens and endotoxin. Blood. 1996;88:3230–3239
  34. Maury S, Salomon B, Klatzmann D, et al. Division rate and phenotypic differences discriminate alloreactive and nonalloreactive T cells transferred in lethally irradiated mice. Blood. 2001;98:3156–3158
  35. Blazar BR, Lees CJ, Martin PJ, et al. Host T cells resist graft-versus-host disease by donor leukocyte infusions. J Immunol. 2000;165:4901–4909
  36. Tan JT, Ernst B, Kieper WC, et al. Interleukin (IL)-15 and IL-7 jointly regulate homeostatic proliferation of memory phenotype CD8+ cells but are not required for memory phenotype CD4+ cells. J Exp Med. 2002;195:1523–1532
  37. Schluns KS, Lefrancois L. Cytokine control of memory T cell development and survival. Nat Rev Immunol. 2003;3:269–279
  38. Fry TJ, Connick E, Fallon J, et al. A potential role for interleukin-7 in T-cell homeostasis. Blood. 2001;97:2983–2990
  39. Mathur A, Vallera DA, Taylor PA, et al. Effect of IL-7 or IL-4 on reconstitution of donor lymphoid cells in congenic bone marrow transplantation. Bone Marrow Transplant. 1995;16:119–124
  40. Gendelman M, Hecht T, Logan B, et al. Host conditioning is a primary determinant in modulating the effect of IL-7 on murine graft-versus-host disease. J Immunol. 2004;172:3328–3336
  41. Bolotin E, Annett G, Parkman R, et al. Serum levels of IL-7 in bone marrow transplant recipients: relationship to clinical characteristics and lymphocyte count. Bone Marrow Transplant. 1999;23:783–788
  42. Llano A, Barretina J, Gutierrez A, et al. Interleukin-7 in plasma correlates with CD4 T-cell depletion and may be associated with emergence of syncytium-inducing variants in human immunodeficiency virus type1-positive individuals. J Virol. 2001;75:10319–10325
  43. Napolitano LA, Grant RM, Deeks SG, et al. Increased production of IL-7 accompanies HIV-1-mediated T-cell depletion: implications for T-cell homeostasis. Nat Med. 2001;7:73–79
  44. Sakajuchi S, Takahashi T, Nishizuka Y. Study on cellular events on post-thymectomy autoimmune oophoritis in mice. II. Requirement of Lyt-1 cells in normal female mice for the prevention of oophoritis. J Exp Med. 1982;156:1577–1586
  45. Sakaguchi S, Sakaguchi N. Thymus and autoimmunity: capacity of the normal thymus to produce pathogenic self-reactive T cells and conditions required for the induction of autoimmune disease. J Exp Med. 1990;172:537–545
  46. Alpdogan O, van den Brink MR. IL-7 and IL-15: therapeutic cytokines for immunodeficiency. Trends Immunol. 2005;26:56–64
  47. Chung B, Dudl EP, Min D, Barsky L, et al. Prevention of graft-versus-host disease by anti-IL-7Rα antibody. Blood. 2007;110:2803–2810

PII: S1083-8791(07)00463-6

doi: 10.1016/j.bbmt.2007.07.015

Biology of Blood and Marrow Transplantation
Volume 14, Issue 1 , Pages 16-27 , January 2008