Biology of Blood and Marrow Transplantation
Volume 14, Issue 1 , Pages 67-74 , January 2008

Recipient NOD2/CARD15 Variants: A Novel Independent Risk Factor for the Development of Bronchiolitis Obliterans after Allogeneic Stem Cell Transplantation

  • Gerhard C. Hildebrandt

      Affiliations

    • Department of Hematology and Oncology, University of Regensburg Medical School, Regensburg, Germany
    • Corresponding Author InformationCorrespondence and reprint requests: Gerhard C Hildebrandt, Department of Hematology and Oncology, University of Regensburg Medical School, Franz-Josef-Strauß Allee 11, D-93053 Regensburg, Germany; Tel: +49-941-944-5589, Fax: +49-941-944-5511.
    • ,
  • Miguell Granell

      Affiliations

    • Department of Hematology, Faculty of Medicine, University of Barcelona, Barcelona, Spain
    • ,
  • Alvaro Urbano-Ispizua

      Affiliations

    • Department of Hematology, Faculty of Medicine, University of Barcelona, Barcelona, Spain
    • ,
  • Daniel Wolff

      Affiliations

    • Department of Hematology and Oncology, University of Rostock Medical School, Rostock, Germany
    • ,
  • Bernd Hertenstein

      Affiliations

    • Department of Hematology, Hannover Medical University, Hannover, Germany
    • ,
  • Hildegard T. Greinix

      Affiliations

    • Department of Internal Medicine I, Vienna Medical University, Vienna, Austria
    • ,
  • Julia Brenmoehl

      Affiliations

    • Department of Hematology and Oncology, University of Regensburg Medical School, Regensburg, Germany
    • ,
  • Christian Schulz

      Affiliations

    • Department of Pulmonology, University of Regensburg Medical School, Regensburg, Germany
    • ,
  • Anne M. Dickinson

      Affiliations

    • School of Clinical and Laboratory Sciences, University of Newcastle, Newcastle, United Kingdom
    • ,
  • Joachim Hahn

      Affiliations

    • Department of Hematology and Oncology, University of Regensburg Medical School, Regensburg, Germany
    • ,
  • Gerhard Rogler

      Affiliations

    • Department of Gastroenterology, University of Regensburg Medical School, Regensburg, Germany
    • ,
  • Reinhard Andreesen

      Affiliations

    • Department of Hematology and Oncology, University of Regensburg Medical School, Regensburg, Germany
    • ,
  • Ernst Holler

      Affiliations

    • Department of Hematology and Oncology, University of Regensburg Medical School, Regensburg, Germany

Received 29 April 2007 ,Accepted 20 September 2007.

  • Image Result

    NOD2/CARD15 variants (var) of the recipient independently increase the risk of developing BO after allo-SCT. A, Frequency of NOD2/CARD15 variants in donors and recipients of patients with (n = 11) and

    NOD2/CARD15 variants (var) of the recipient independently increase the risk of developing BO after allo-SCT. A, Frequency of NOD2/CARD15 variants in donors and recipients of patients with (n = 11) and without (n = 416) BO (∗P < .05). B-D, Cumulative incidence of BO after allo-SCT depending on whether (B) the recipient, the donor, or both carry a NOD2/CARD15 variant (n =104); (C) only the recipient has a NOD2/CARD15 variant (n = 49); or (D) only the donor has a NOD2/CARD15 mutation (n = 37). Wt represents wild-type controls, that is, neither donor nor recipient has a NOD2/CARD15 variant (n = 323) (∗P < .05; ∗∗P < .01). E, Chronic GVHD and recipient NOD2/CARD15 variant are independent risk factors for BO development.

 Dr. Hildebrandt is a Max Eder Scholar of the Deutsche Krebshilfe eV and a Research Scholar of the European Hematology Association.

PII: S1083-8791(07)00464-8

doi: 10.1016/j.bbmt.2007.09.009

Biology of Blood and Marrow Transplantation
Volume 14, Issue 1 , Pages 67-74 , January 2008

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